发明授权
US08252779B2 Analogs of benzoquinone-containing ansamycins and methods of use thereof
有权
含有苯醌的安莎霉素的类似物及其使用方法
- 专利标题： Analogs of benzoquinone-containing ansamycins and methods of use thereof
- 专利标题（中）： 含有苯醌的安莎霉素的类似物及其使用方法
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申请号： US13191761申请日： 2011-07-27
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公开(公告)号： US08252779B2公开(公告)日： 2012-08-28
- 发明人: Julian Adams , Yun Gao , Asimina T. Georges Evangelinos , Louis Grenier , Roger H. Pak , James R. Porter , James L. Wright
- 申请人： Julian Adams , Yun Gao , Asimina T. Georges Evangelinos , Louis Grenier , Roger H. Pak , James R. Porter , James L. Wright
- 申请人地址： US MA Cambridge
- 专利权人： Infinity Pharmaceuticals, Inc.
- 当前专利权人： Infinity Pharmaceuticals, Inc.
- 当前专利权人地址： US MA Cambridge
- 代理机构： Foley Hoag LLP
- 主分类号： A61K31/33
- IPC分类号： A61K31/33
摘要：
The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer. The present invention provides analogs of benzoquinone-containing ansamycins where the benzoquinone is reduced to a hydroquinone and trapped by reaction with a suitable acid, preferably ones that increase the solubility and air stability of the resulting 17-ammonium hydroquinone ansamycin analog.
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