发明授权
- 专利标题： Compounds and methods for modulating activation of NF-κB
- 专利标题（中）： 调节NF-κB活化的化合物和方法B
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申请号： US12189048申请日： 2008-08-08
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公开(公告)号： US08263326B2公开(公告)日： 2012-09-11
- 发明人: Anthony M. Manning , Frank Mercurio , Sharon Amit , Yinon Ben-Neriah , Matti Davis , Ada Hatzubai , Avraham Yaron , Irit Alkalay , Aaron Ciechanover
- 申请人： Anthony M. Manning , Frank Mercurio , Sharon Amit , Yinon Ben-Neriah , Matti Davis , Ada Hatzubai , Avraham Yaron , Irit Alkalay , Aaron Ciechanover
- 申请人地址： US CA San Deigo
- 专利权人： Signal Pharmaceuticals, LLC
- 当前专利权人： Signal Pharmaceuticals, LLC
- 当前专利权人地址： US CA San Deigo
- 代理机构： Jones Day
- 主分类号： C12Q1/25
- IPC分类号： C12Q1/25 ; C12N9/00
摘要：
Compositions and methods for modulating the activation of nuclear factor κB (NF-κB) are provided. The compositions comprise one or more agents that modulate ubiquitination of phosphorylated IκBα and/or IκBβ. Such compositions may be used for treating diseases associated with NF-κB activation. Modulating agents include human E3 ubiquitin ligases, antibodies thereto and variants thereof, as well as related proteins.
公开/授权文献
- US20090233855A1 COMPOUNDS AND METHODS FOR MODULATING ACTIVATION OF NF-KB 公开/授权日：2009-09-17
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