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公开(公告)号：US20090233855A1
公开(公告)日：2009-09-17
申请号：US12189048
申请日：2008-08-08
申请人： Anthony M. MANNING , Frank Mercurio , Sharon Amit , Yinon Ben-Neriah , Matti Davis , Ada Hatzubai , Avraham Yaron , Irit Alkalay , Aaron Ciechanover
发明人： Anthony M. MANNING , Frank Mercurio , Sharon Amit , Yinon Ben-Neriah , Matti Davis , Ada Hatzubai , Avraham Yaron , Irit Alkalay , Aaron Ciechanover
CPC分类号： C12N9/93 , A61K38/00 , C12Y603/02019
摘要： Compositions and methods for modulating the activation of nuclear factor κB (NF-κB) are provided. The compositions comprise one or more agents that modulate ubiquitination of phosphorylated IκBα and/or IκBβ Such compositions may be used for treating diseases associated with NF-κB activation. Modulating agents include human E3 ubiquitin ligases, antibodies thereto and variants thereof, as well as related proteins.
摘要翻译： 提供了调节核因子κB（NF-κB）活化的组成和方法。 组合物包含调节磷酸化IkappaBalpha和/或IkappaBβ的泛素化的一种或多种试剂。该组合物可用于治疗与NF-κB活化相关的疾病。 调节剂包括人E3泛素连接酶，抗体及其变体，以及相关蛋白质。
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公开(公告)号：US06656713B2
公开(公告)日：2003-12-02
申请号：US09832161
申请日：2001-04-09
申请人： Anthony M. Manning , Frank Mercurio , Sharon Amit , Yinon Ben-Neriah , Matti Davis , Ada Hatzubai , Avraham Yaron , Irit Alkalay , Aaron Ciechanover
发明人： Anthony M. Manning , Frank Mercurio , Sharon Amit , Yinon Ben-Neriah , Matti Davis , Ada Hatzubai , Avraham Yaron , Irit Alkalay , Aaron Ciechanover
IPC分类号： C12N900
CPC分类号： C12N9/93 , A61K38/00 , C12Y603/02019
摘要： Compositions and methods for modulating the activation of nuclear factor &kgr;B (NF-&kgr;B) are provided. The compositions comprise one or more agents that modulate ubiquitination of phosphorylated I&kgr;B&agr; and/or I&kgr;B&bgr;. Such compositions may be used for treating diseases associated with NF-&kgr;B activation. Modulating agents include human E3 ubiquitin ligases, antibodies thereto and variants thereof, as well as related proteins.
摘要翻译： 提供了调节核因子κB（NF-κB）活化的组成和方法。 组合物包含一种或多种调节磷酸化IkappaBalpha和/或IkappaBβ的泛素化的试剂。 这样的组合物可用于治疗与NF-κB活化相关的疾病。 调节剂包括人E3泛素连接酶，抗体及其变体，以及相关蛋白质。
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公开(公告)号：US08263326B2
公开(公告)日：2012-09-11
申请号：US12189048
申请日：2008-08-08
申请人： Anthony M. Manning , Frank Mercurio , Sharon Amit , Yinon Ben-Neriah , Matti Davis , Ada Hatzubai , Avraham Yaron , Irit Alkalay , Aaron Ciechanover
发明人： Anthony M. Manning , Frank Mercurio , Sharon Amit , Yinon Ben-Neriah , Matti Davis , Ada Hatzubai , Avraham Yaron , Irit Alkalay , Aaron Ciechanover
CPC分类号： C12N9/93 , A61K38/00 , C12Y603/02019
摘要： Compositions and methods for modulating the activation of nuclear factor κB (NF-κB) are provided. The compositions comprise one or more agents that modulate ubiquitination of phosphorylated IκBα and/or IκBβ. Such compositions may be used for treating diseases associated with NF-κB activation. Modulating agents include human E3 ubiquitin ligases, antibodies thereto and variants thereof, as well as related proteins.
摘要翻译： 提供用于调节核因子激活的组合物和方法B（NF-κB）。 所述组合物包含一种或多种调节磷酸化Iα和Bα和/或I＆Kgr; B＆bgr的泛素化的试剂。 此类组合物可用于治疗与NF-κB活化相关的疾病。 调节剂包括人E3泛素连接酶，抗体及其变体，以及相关蛋白质。
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公开(公告)号：US07414120B2
公开(公告)日：2008-08-19
申请号：US11698848
申请日：2007-01-25
申请人： Anthony M. Manning , Frank Mercurio , Sharo Amit , Yinon Ben-Neriah , Matti Davis , Ada Hatzubai , Avraham Yaron , Irit Alkalay , Aaron Ciechanover
发明人： Anthony M. Manning , Frank Mercurio , Sharo Amit , Yinon Ben-Neriah , Matti Davis , Ada Hatzubai , Avraham Yaron , Irit Alkalay , Aaron Ciechanover
CPC分类号： C12N9/93 , A61K38/00 , C12Y603/02019
摘要： Compositions and methods for modulating the activation of nuclear factor κB (NF-κB) are provided. The compositions comprise one or more agents that modulate ubiquitination of phosphorylated IκBα and/or IκBβ. Such compositions may be used for treating diseases associated with NF-κB activation. Modulating agents include human E3 ubiquitin ligases, antibodies thereto and variants thereof, as well as related proteins.
摘要翻译： 提供了调节核因子κB（NF-κB）活化的组成和方法。 组合物包含一种或多种调节磷酸化IkappaBalpha和/或IkappaBβ的泛素化的试剂。 这样的组合物可用于治疗与NF-κB活化相关的疾病。 调节剂包括人E3泛素连接酶，抗体及其变体，以及相关蛋白质。
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公开(公告)号：US07186503B2
公开(公告)日：2007-03-06
申请号：US10665715
申请日：2003-09-19
申请人： Anthony M. Manning , Frank Mercurio , Sharo Amit , Yinon Ben-Neriah , Matti Davis , Ada Hatzubai , Avraham Yaron , Irit Alkalay , Aaron Ciechanover
发明人： Anthony M. Manning , Frank Mercurio , Sharo Amit , Yinon Ben-Neriah , Matti Davis , Ada Hatzubai , Avraham Yaron , Irit Alkalay , Aaron Ciechanover
CPC分类号： C12N9/93 , A61K38/00 , C12Y603/02019
摘要： Compositions and methods for modulating the activation of nuclear factor κB (NF-κB) are provided. The compositions comprise one or more agents that modulate ubiquitination of phosphorylated IκBα and/or IκBβ. Such compositions may be used for treating diseases associated with NF-κB activation. Modulating agents include human E3 ubiquitin ligases, antibodies thereto and variants thereof, as well as related proteins.
摘要翻译： 提供了调节核因子κB（NF-κB）活化的组成和方法。 组合物包含一种或多种调节磷酸化IkappaBalpha和/或IkappaBβ的泛素化的试剂。 这样的组合物可用于治疗与NF-κB活化相关的疾病。 调节剂包括人E3泛素连接酶，抗体及其变体，以及相关蛋白质。
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公开(公告)号：US20070208167A1
公开(公告)日：2007-09-06
申请号：US11698848
申请日：2007-01-25
申请人： Anthony Manning , Frank Mercurio , Sharon Amit , Yinon Ben-Neriah , Matti Davis , Ada Hatzubai , Avraham Yaron , Irit Alkalay , Aaron Ciechanover
发明人： Anthony Manning , Frank Mercurio , Sharon Amit , Yinon Ben-Neriah , Matti Davis , Ada Hatzubai , Avraham Yaron , Irit Alkalay , Aaron Ciechanover
IPC分类号： C07H21/04
CPC分类号： C12N9/93 , A61K38/00 , C12Y603/02019
摘要： Compositions and methods for modulating the activation of nuclear factor κB (NF-κB) are provided. The compositions comprise one or more agents that modulate ubiquitination of phosphorylated IκBα and/or IκBβ. Such compositions may be used for treating diseases associated with NF-κB activation. Modulating agents include human E3 ubiquitin ligases, antibodies thereto and variants thereof, as well as related proteins.
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7.发明授权
公开(公告)号：US5932425A
公开(公告)日：1999-08-03
申请号：US802322
申请日：1997-02-18
申请人： Irit Alkalay , Yinon Ben-Neriah , Aaron Ciechanover , Anthony Manning , Frank Mercurio , Avraham Yaron
发明人： Irit Alkalay , Yinon Ben-Neriah , Aaron Ciechanover , Anthony Manning , Frank Mercurio , Avraham Yaron
IPC分类号： C12N15/09 , A61K38/00 , A61K45/00 , A61P29/00 , A61P31/12 , A61P35/00 , A61P37/06 , C07K14/47 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12Q1/02 , G01N33/53 , A01N37/18 , C12Q1/00
CPC分类号： C07K14/4702 , A61K38/00
摘要： Compositions and methods for modulating the activation of nuclear factor .kappa.B (NF-.kappa.B) are provided. The compositions comprise one or more agents that modulate ubiquitination of phosphorylated I.kappa.B.alpha. and/or I.kappa.B.beta.. Such compositions may be used for treating diseases associated with NF-.kappa.B activation. Modulating agents include peptides that comprise a recognition domain for E3 ubiquitin ligase.
摘要翻译： 提供了调节核因子κB（NF-κB）活化的组合物和方法。 组合物包含一种或多种调节磷酸化IκBα和/或IκBβ的泛素化的试剂。 这样的组合物可用于治疗与NF-κB活化相关的疾病。 调节剂包括构成E3泛素连接酶识别结构域的肽。
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公开(公告)号：US20060003939A1
公开(公告)日：2006-01-05
申请号：US10431638
申请日：2003-05-08
申请人： Hermann Steller , Hyung Ryoo , Aaron Ciechanover , Hedva Gonen
发明人： Hermann Steller , Hyung Ryoo , Aaron Ciechanover , Hedva Gonen
CPC分类号： C07K14/4747 , A61K38/00 , C07K7/06 , C07K7/08 , C12N2799/026
摘要： The present invention provides novel peptides, nucleic acids, compounds, compositions and methods for regulating apoptosis, and screening methods for identifying same. Regulation of apoptosis is mediated via IAPi-derived proteins, peptide fragments thereof, and nucleic acids encoding same, stimulating/accelerating or downmodulating/suppressing apoptosis. For stimulation/acceleration of apoptosis, the IAPi-derived proteins or peptide fragments thereof comprise RHG and Trp-box amino acid consensus sequences. Stimulation/acceleration results in self-ubiquitination and auto-degradation of an IAP. For downmodulation/suppression of apoptosis, IAPi-derived proteins or peptide fragments thereof comprising either RHG or Trp-box amino acid consensus sequences, or both, failing to stimulate or suppressing self-ubiquitination and auto-degradation of an IAP, result in suppression of apoptosis.
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公开(公告)号：US07507788B2
公开(公告)日：2009-03-24
申请号：US10431638
申请日：2003-05-08
IPC分类号： C07K5/00
CPC分类号： C07K14/4747 , A61K38/00 , C07K7/06 , C07K7/08 , C12N2799/026
摘要： The present invention provides novel peptides, nucleic acids, compounds, compositions and methods for regulating apoptosis, and screening methods for identifying same. Regulation of apoptosis is mediated via IAPi-derived proteins, peptide fragments thereof, and nucleic acids encoding same, stimulating/accelerating or downmodulating/suppressing apoptosis. For stimulation/acceleration of apoptosis, the IAPi-derived proteins or peptide fragments thereof comprise RHG and Trp-box amino acid consensus sequences. Stimulation/acceleration results in self-ubiquitination and auto-degradation of an IAP. For downmodulation/suppression of apoptosis, IAPi-derived proteins or peptide fragments thereof comprising either RHG or Trp-box amino acid consensus sequences, or both, failing to stimulate or suppressing self-ubiquitination and auto-degradation of an IAP, result in suppression of apoptosis.
摘要翻译： 本发明提供了用于调节凋亡的新型肽，核酸，化合物，组合物和方法以及用于鉴定其的筛选方法。 细胞凋亡调控是通过IAPi衍生的蛋白质，其肽片段和编码相同的核酸，刺激/加速或下调/抑制细胞凋亡介导的。 对于刺激/加速凋亡，IAPi衍生的蛋白质或其肽片段包含RHG和Trp-box氨基酸共有序列。 刺激/加速导致IAP的自我泛素化和自我降解。 对于凋亡的下调/抑制，包含RHG或Trp-box氨基酸共有序列或两者的IAPI衍生的蛋白质或其肽片段或者两者都不能刺激或抑制IAP的自泛素化和自身降解，导致抑制 凋亡。
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公开(公告)号：US20060058229A1
公开(公告)日：2006-03-16
申请号：US10513465
申请日：2003-05-08
申请人： Hermann Steller , Hyung Ryoo , Aaron Ciechanover , Hedva Gonen
发明人： Hermann Steller , Hyung Ryoo , Aaron Ciechanover , Hedva Gonen
IPC分类号： A61K38/17
CPC分类号： C07K14/4747 , A61K38/00
摘要： The present invention provides novel peptides, nucleic acids, compounds, compositions and methods for regulating apoptosis, and screening methods for identifying same. Regulation of apoptosis is mediated via IAPi-derived proteins, peptide fragments thereof, and nucleic acids encoding same, stimulating/accelerating or downmodulating/suppressing apoptosis. For stimulation/acceleration of apoptosis, the IAPi-derived proteins or peptide fragments thereof comprise RHG and Trp-box amino acid consensus sequences. Stimulation/acceleration results in self-ubiquitination and auto-degradation of an IAP. For downmodulation/suppression of apoptosis, IAPi-derived proteins or peptide fragments thereof comprising either RHG or Trp-box amino acid consensus sequences, or both, failing to stimulate or suppressing self-ubiquitination and auto-degradation of an IAP, result in suppression of apoptosis.
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