发明授权
- 专利标题: Anti-amyloid antibodies
- 专利标题(中): 抗淀粉样蛋白抗体
-
申请号: US13187093申请日: 2011-07-20
-
公开(公告)号: US08268973B2公开(公告)日: 2012-09-18
- 发明人: Dale B. Schenk , Peter A. Seubert , José Saldanha
- 申请人: Dale B. Schenk , Peter A. Seubert , José Saldanha
- 申请人地址: IE Dublin
- 专利权人: Onclave Therapeutics
- 当前专利权人: Onclave Therapeutics
- 当前专利权人地址: IE Dublin
- 代理机构: Womble Carlyle Sandridge & Rice, LLP
- 主分类号: C07K16/18
- IPC分类号: C07K16/18 ; A61K39/395 ; C07H21/04 ; C12N5/07 ; C12N5/10 ; C12N5/20 ; C12P21/08
摘要:
Methods useful for effecting prophylaxis or treatment of amyloidosis, including AA Amyloidosis and AL amyloidosis, by administering peptides comprising neoepitopes, such as AA fragments from a C-terminal region of AA, and antibodies specific for neoepitopes of aggregated amyloid proteins, for example, antibodies specific for the C-terminal region of AA fibrils. Antibodies for inhibition of formation and/or increasing clearance of amyloid deposits in a patient thus effecting prophylaxis or treating amyloid disease.
公开/授权文献
- US20120039878A1 TREATMENT AND PROPHYLAXIS OF AMYLOIDOSIS 公开/授权日:2012-02-16