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公开(公告)号:US08636981B2
公开(公告)日:2014-01-28
申请号:US13314160
申请日:2011-12-07
申请人: Dale B. Schenk , Peter A. Seubert , Jonathan Wall
发明人: Dale B. Schenk , Peter A. Seubert , Jonathan Wall
CPC分类号: C07K16/18 , A61K39/0008 , A61K49/00 , A61K49/16 , A61K51/1018 , A61K2039/505 , C07K2317/24 , C07K2317/32 , C07K2317/34 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/92 , Y10S530/809
摘要: Methods useful for effecting prophylaxis or treatment of amyloidosis, including AA Amyloidosis and AL amyloidosis, by administering peptides comprising neoepitopes, such as AA fragments from a C-terminal region of AA, and antibodies specific for neoepitopes of aggregated amyloid proteins, for example, antibodies specific for the C-terminal region of AA fibrils. Antibodies for inhibition of formation and/or increasing clearance of amyloid deposits in a patient thus effecting prophylaxis or treating amyloid disease.
摘要翻译: 通过施用包含新表皮的肽,例如来自AA的C末端区域的AA片段和对聚集的淀粉样蛋白的新表皮特异的抗体,例如抗体,可用于预防或治疗淀粉样变性(包括AA淀粉样变性和AL淀粉样变性)的方法 特异于AA原纤维的C-末端区域。 用于抑制形成和/或增加患者淀粉样沉积物清除率的抗体,从而实现预防或治疗淀粉样蛋白病。
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公开(公告)号:US20150158937A1
公开(公告)日:2015-06-11
申请号:US14315040
申请日:2014-06-25
发明人: Dale B. SCHENK , Peter A. SEUBERT , José SALDANHA
IPC分类号: C07K16/18
CPC分类号: A61K39/0008 , A61K49/00 , A61K49/16 , A61K51/1018 , A61K2039/505 , C07K16/18 , C07K2317/24 , C07K2317/32 , C07K2317/34 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/92 , Y10S530/809
摘要: Methods useful for effecting prophylaxis or treatment of amyloidosis, including AA Amyloidosis and AL amyloidosis, by administering peptides comprising neoepitopes, such as AA fragments from a C-terminal region of AA, and antibodies specific for neoepitopes of aggregated amyloid proteins, for example, antibodies specific for the C-terminal region of AA fibrils. Antibodies for inhibition of formation and/or increasing clearance of amyloid deposits in a patient thus effecting prophylaxis or treating amyloid disease.
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公开(公告)号:US08791243B2
公开(公告)日:2014-07-29
申请号:US12811049
申请日:2008-12-29
申请人: Dale B. Schenk , Peter A. Seubert , Jonathan Wall , Jose Saldanha
发明人: Dale B. Schenk , Peter A. Seubert , Jonathan Wall , Jose Saldanha
IPC分类号: C07K16/18 , A61K39/395 , C12N5/07
CPC分类号: C07K16/18 , A61K39/0008 , A61K49/00 , A61K49/16 , A61K51/1018 , A61K2039/505 , C07K2317/24 , C07K2317/32 , C07K2317/34 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/92 , Y10S530/809
摘要: Methods useful for effecting prophylaxis or treatment of amyloidosis, including AA Amyloidosis and AL amyloidosis, by administering peptides comprising neoepitopes, such as AA fragments from a C-terminal region of AA, and antibodies specific for neoepitopes of aggregated amyloid proteins, for example, antibodies specific for the C-terminal region of AA fibrils. Antibodies for inhibition of formation and/or increasing clearance of amyloid deposits in a patient thus effecting prophylaxis or treating amyloid disease.
摘要翻译: 通过施用包含新表皮的肽,例如来自AA的C末端区域的AA片段和对聚集的淀粉样蛋白的新表皮特异的抗体,例如抗体,可用于预防或治疗淀粉样变性(包括AA淀粉样变性和AL淀粉样变性)的方法 特异于AA原纤维的C-末端区域。 用于抑制形成和/或增加患者淀粉样沉积物清除率的抗体,从而实现预防或治疗淀粉样蛋白病。
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公开(公告)号:US20130295082A1
公开(公告)日:2013-11-07
申请号:US13660957
申请日:2012-10-25
IPC分类号: A61K39/395 , A61K38/07 , A61K31/454 , A61K31/198 , A61K31/69
CPC分类号: A61K9/19 , A61K31/195 , A61K31/198 , A61K31/454 , A61K31/69 , A61K38/07 , A61K39/3955 , A61K39/39591 , A61K47/22 , A61K47/26 , A61K2039/505 , A61K2039/545 , C07K16/18 , C07K2317/14 , C07K2317/24 , C07K2317/41 , C07K2317/56 , C07K2317/565 , C07K2317/76
摘要: Antibody formulations and methods useful for prophylaxis or treatment of amyloidosis, including AA amyloidosis and AL amyloidosis.
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公开(公告)号:US08404815B2
公开(公告)日:2013-03-26
申请号:US13032412
申请日:2011-02-22
申请人: Dale B. Schenk , Peter A. Seubert
发明人: Dale B. Schenk , Peter A. Seubert
CPC分类号: C07K16/18 , A61K39/0008 , A61K49/00 , A61K49/16 , A61K51/1018 , A61K2039/505 , C07K2317/24 , C07K2317/32 , C07K2317/34 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/92 , Y10S530/809
摘要: Methods useful for effecting prophylaxis or treatment of amyloidosis, including AA Amyloidosis and AL amyloidosis, by administering peptides comprising neoepitopes, such as AA fragments from a C-terminal region of AA, and antibodies specific for neoepitopes of aggregated amyloid proteins, for example, antibodies specific for the C-terminal region of AA fibrils. Antibodies for inhibition of formation and/or increasing clearance of amyloid deposits in a patient thus effecting prophylaxis or treating amyloid disease.
摘要翻译: 通过施用包含新表皮的肽,例如来自AA的C末端区域的AA片段和对聚集的淀粉样蛋白的新表皮特异的抗体,例如抗体,可用于预防或治疗淀粉样变性(包括AA淀粉样变性和AL淀粉样变性)的方法 特异于AA原纤维的C-末端区域。 用于抑制形成和/或增加患者淀粉样沉积物清除率的抗体,从而实现预防或治疗淀粉样蛋白病。
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公开(公告)号:US08268973B2
公开(公告)日:2012-09-18
申请号:US13187093
申请日:2011-07-20
申请人: Dale B. Schenk , Peter A. Seubert , José Saldanha
发明人: Dale B. Schenk , Peter A. Seubert , José Saldanha
CPC分类号: C07K16/18 , A61K39/0008 , A61K49/00 , A61K49/16 , A61K51/1018 , A61K2039/505 , C07K2317/24 , C07K2317/32 , C07K2317/34 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/92 , Y10S530/809
摘要: Methods useful for effecting prophylaxis or treatment of amyloidosis, including AA Amyloidosis and AL amyloidosis, by administering peptides comprising neoepitopes, such as AA fragments from a C-terminal region of AA, and antibodies specific for neoepitopes of aggregated amyloid proteins, for example, antibodies specific for the C-terminal region of AA fibrils. Antibodies for inhibition of formation and/or increasing clearance of amyloid deposits in a patient thus effecting prophylaxis or treating amyloid disease.
摘要翻译: 通过施用包含新表皮的肽,例如来自AA的C末端区域的AA片段和对聚集的淀粉样蛋白的新表皮特异的抗体,例如抗体,可用于预防或治疗淀粉样变性(包括AA淀粉样变性和AL淀粉样变性)的方法 特异于AA原纤维的C-末端区域。 用于抑制形成和/或增加患者淀粉样沉积物清除率的抗体,从而实现预防或治疗淀粉样蛋白病。
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