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公开(公告)号:US08268973B2
公开(公告)日:2012-09-18
申请号:US13187093
申请日:2011-07-20
申请人: Dale B. Schenk , Peter A. Seubert , José Saldanha
发明人: Dale B. Schenk , Peter A. Seubert , José Saldanha
CPC分类号: C07K16/18 , A61K39/0008 , A61K49/00 , A61K49/16 , A61K51/1018 , A61K2039/505 , C07K2317/24 , C07K2317/32 , C07K2317/34 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/92 , Y10S530/809
摘要: Methods useful for effecting prophylaxis or treatment of amyloidosis, including AA Amyloidosis and AL amyloidosis, by administering peptides comprising neoepitopes, such as AA fragments from a C-terminal region of AA, and antibodies specific for neoepitopes of aggregated amyloid proteins, for example, antibodies specific for the C-terminal region of AA fibrils. Antibodies for inhibition of formation and/or increasing clearance of amyloid deposits in a patient thus effecting prophylaxis or treating amyloid disease.
摘要翻译: 通过施用包含新表皮的肽,例如来自AA的C末端区域的AA片段和对聚集的淀粉样蛋白的新表皮特异的抗体,例如抗体,可用于预防或治疗淀粉样变性(包括AA淀粉样变性和AL淀粉样变性)的方法 特异于AA原纤维的C-末端区域。 用于抑制形成和/或增加患者淀粉样沉积物清除率的抗体,从而实现预防或治疗淀粉样蛋白病。
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公开(公告)号:US07402410B2
公开(公告)日:2008-07-22
申请号:US11511164
申请日:2006-08-28
申请人: Paul D. Ponath , Douglas J. Ringler , S. Tarran Jones , Walter Newman , José Saldanha , Mary M. Bendig
发明人: Paul D. Ponath , Douglas J. Ringler , S. Tarran Jones , Walter Newman , José Saldanha , Mary M. Bendig
CPC分类号: C07K16/2839 , A61K38/00 , C07K14/70503 , C07K2317/24 , C07K2319/00
摘要: The present invention relates to isolated nucleic acids encoding humanized immunoglobulins having binding specificity for α4β7 integrin, isolated nucleic acids encoding a humanized immunoglobulin heavy chain and isolated nucleic acids encoding a humanized light chain having binding specificity for α4β7 integrin. The invention also relates to expression vectors and host cells comprising a nucleotide sequence which encodes a humanized immunoglobulin or antigen-binding fragment thereof having binding specificity for α4β7. The invention further relates to methods of preparing a humanized immunoglobulin, humanized immunoglobulin heavy chain and humanized immunoglobulin light chain that has binding specificity for α4β7 integrin.
摘要翻译: 本发明涉及编码对α4β7整联蛋白具有结合特异性,编码人源化免疫球蛋白重链的分离的核酸和编码具有α4β7整联蛋白的结合特异性的人源化轻链的分离的核酸的分离的核酸。 本发明还涉及包含编码具有对α4β7具有结合特异性的人源化免疫球蛋白或其抗原结合片段的核苷酸序列的表达载体和宿主细胞。 本发明还涉及制备对α4β7整联蛋白具有结合特异性的人源化免疫球蛋白,人源化免疫球蛋白重链和人源化免疫球蛋白轻链的方法。
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公开(公告)号:US07147851B1
公开(公告)日:2006-12-12
申请号:US08700737
申请日:1996-08-15
申请人: Paul D. Ponath , Douglas J. Ringler , S. Tarran Jones , Walter Newman , José Saldanha , Mary M. Bendig
发明人: Paul D. Ponath , Douglas J. Ringler , S. Tarran Jones , Walter Newman , José Saldanha , Mary M. Bendig
IPC分类号: A61K39/395 , C07K16/28 , C07K16/18
CPC分类号: C07K16/2839 , A61K38/00 , C07K14/70503 , C07K2317/24 , C07K2319/00
摘要: The present invention relates to humanized immunoglobulins having binding specificity for α4β7 integrin, comprising an antigen binding region of nonhuman origin (e.g., rodent) and at least a portion of an immunoglobulin of human origin (e.g., a human framework region, a human constant region). In one embodiment, the humanized immunoglobulin can compete with murine Act-1 for binding to human α4β7 integrin. In a preferred embodiment, the antigen binding region of the humanized immunoglobulin comprises each of the complementarity determining regions of the light and heavy chains of the murine Act-1 antibody.
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公开(公告)号:US20140134103A1
公开(公告)日:2014-05-15
申请号:US14099692
申请日:2013-12-06
申请人: Dale B. SCHENK , Peter A. Seubert , Jonathan Wall , José Saldanha
发明人: Dale B. SCHENK , Peter A. Seubert , Jonathan Wall , José Saldanha
CPC分类号: A61K39/0008 , A61K49/00 , A61K49/16 , A61K51/1018 , A61K2039/505 , C07K16/18 , C07K2317/24 , C07K2317/32 , C07K2317/34 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/92 , Y10S530/809
摘要: Methods useful for effecting prophylaxis or treatment of amyloidosis, including AA Amyloidosis and AL amyloidosis, by administering peptides comprising neoepitopes, such as AA fragments from a C-terminal region of AA, and antibodies specific for neoepitopes of aggregated amyloid proteins, for example, antibodies specific for the C-terminal region of AA fibrils. Antibodies for inhibition of formation and/or increasing clearance of amyloid deposits in a patient thus effecting prophylaxis or treating amyloid disease.
摘要翻译: 通过施用包含新表皮的肽,例如来自AA的C末端区域的AA片段和对聚集的淀粉样蛋白的新表皮特异的抗体,例如抗体,可用于预防或治疗淀粉样变性(包括AA淀粉样变性和AL淀粉样变性)的方法 特异于AA原纤维的C-末端区域。 用于抑制形成和/或增加患者淀粉样沉积物清除率的抗体,从而实现预防或治疗淀粉样蛋白病。
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