发明授权
- 专利标题： Inhibitors of vascular endothelial growth factor activity
- 专利标题（中）： 抑制血管内皮生长因子活性
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申请号： US13096723申请日： 2011-04-28
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公开(公告)号： US08273353B2公开(公告)日： 2012-09-25
- 发明人: Terri Lynn Davis-Smyth , Helen Hsifei Chen , Leonard Presta , Napoleone Ferrara
- 申请人： Terri Lynn Davis-Smyth , Helen Hsifei Chen , Leonard Presta , Napoleone Ferrara
- 申请人地址： US CA South San Francisco
- 专利权人： Genentech, Inc.
- 当前专利权人： Genentech, Inc.
- 当前专利权人地址： US CA South San Francisco
- 代理机构： Jones Day
- 主分类号： A61K38/18
- IPC分类号： A61K38/18 ; C07K14/71
摘要：
The present invention is directed to novel chimeric VEGF receptor proteins comprising amino acid sequences derived from the vascular endothelial growth factor (VEGF) receptors flt-1 and KDR, including the murine homologue to the human KDR receptor FLK-1, wherein said chimeric VEGF receptor proteins bind to VEGF and antagonize the endothelial cell proliferative and angiogenic activity thereof. The present invention is also directed to nucleic acids and expression vectors encoding these chimeric VEGF receptor proteins, host cells harboring such expression vectors, pharmaceutically acceptable compositions comprising such proteins, methods of preparing such proteins and to methods utilizing such proteins for the treatment of conditions associated with undesired vascularization.
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