发明授权
- 专利标题: Preparation methods of azoxystrobin and its analogs
- 专利标题(中): 嘧菌酯及其类似物的制备方法
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申请号: US12668219申请日: 2008-09-19
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公开(公告)号: US08278445B2公开(公告)日: 2012-10-02
- 发明人: Shangzhong Liu , Canxian Mu , Wenjun Wang , Jianwei Chen , Shuguang Wang
- 申请人: Shangzhong Liu , Canxian Mu , Wenjun Wang , Jianwei Chen , Shuguang Wang
- 申请人地址: CN Beijing
- 专利权人: Nutrichem Company Limited
- 当前专利权人: Nutrichem Company Limited
- 当前专利权人地址: CN Beijing
- 代理机构: Orrick, Herrington & Sutcliffe, LLP
- 优先权: CN200710163386 20071024
- 国际申请: PCT/CN2008/072429 WO 20080919
- 国际公布: WO2009/052719 WO 20090430
- 主分类号: C07D239/22
- IPC分类号: C07D239/22 ; C07C69/76
摘要:
Preparation method of a compound of general formula (I) comprises the following steps: (1) a compound of general formula (II) reacts with a formylating agent in an aprotic solvent at a temperature between −20° C. and 200° C. in the presence of a Lewis acid, then an organic base is added to promote the reaction to obtain an intermediate product; (2) the above intermediate product reacts with a methylating agent in the presence of an alkali at a temperature between −20° C. and 100° C. to obtain the compound of formula (I).
公开/授权文献
- US20100179320A1 PREPARATION METHODS OF AZOXYSTROBIN AND ITS ANALOGS 公开/授权日:2010-07-15
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