Invention Grant
- Patent Title: Preparation methods of azoxystrobin and its analogs
- Patent Title (中): 嘧菌酯及其类似物的制备方法
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Application No.: US12668219Application Date: 2008-09-19
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Publication No.: US08278445B2Publication Date: 2012-10-02
- Inventor: Shangzhong Liu , Canxian Mu , Wenjun Wang , Jianwei Chen , Shuguang Wang
- Applicant: Shangzhong Liu , Canxian Mu , Wenjun Wang , Jianwei Chen , Shuguang Wang
- Applicant Address: CN Beijing
- Assignee: Nutrichem Company Limited
- Current Assignee: Nutrichem Company Limited
- Current Assignee Address: CN Beijing
- Agency: Orrick, Herrington & Sutcliffe, LLP
- Priority: CN200710163386 20071024
- International Application: PCT/CN2008/072429 WO 20080919
- International Announcement: WO2009/052719 WO 20090430
- Main IPC: C07D239/22
- IPC: C07D239/22 ; C07C69/76

Abstract:
Preparation method of a compound of general formula (I) comprises the following steps: (1) a compound of general formula (II) reacts with a formylating agent in an aprotic solvent at a temperature between −20° C. and 200° C. in the presence of a Lewis acid, then an organic base is added to promote the reaction to obtain an intermediate product; (2) the above intermediate product reacts with a methylating agent in the presence of an alkali at a temperature between −20° C. and 100° C. to obtain the compound of formula (I).
Public/Granted literature
- US20100179320A1 PREPARATION METHODS OF AZOXYSTROBIN AND ITS ANALOGS Public/Granted day:2010-07-15
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