公开(公告)号：US08278445B2

公开(公告)日：2012-10-02

申请号：US12668219

申请日：2008-09-19

申请人： Shangzhong Liu ,  Canxian Mu ,  Wenjun Wang ,  Jianwei Chen ,  Shuguang Wang

发明人： Shangzhong Liu ,  Canxian Mu ,  Wenjun Wang ,  Jianwei Chen ,  Shuguang Wang

IPC分类号： C07D239/22 ,  C07C69/76

CPC分类号： C07C67/31 ,  C07C67/343 ,  C07D239/34 ,  C07D239/52 ,  C07C69/734 ,  C07C69/738

摘要： Preparation method of a compound of general formula (I) comprises the following steps: (1) a compound of general formula (II) reacts with a formylating agent in an aprotic solvent at a temperature between −20° C. and 200° C. in the presence of a Lewis acid, then an organic base is added to promote the reaction to obtain an intermediate product; (2) the above intermediate product reacts with a methylating agent in the presence of an alkali at a temperature between −20° C. and 100° C. to obtain the compound of formula (I).

摘要翻译： 通式（I）化合物的制备方法包括以下步骤：（1）通式（II）的化合物在-20℃至200℃的温度下，在非质子传递溶剂中与甲酰化剂反应。 在路易斯酸存在下，加入有机碱促进反应得到中间产物; （2）上述中间产物在碱存在下，在-20℃至100℃的温度下与甲基化剂反应，得到式（I）化合物。

公开(公告)号：US20100179320A1

公开(公告)日：2010-07-15

申请号：US12668219

申请日：2008-09-19

申请人： Shangzhong Liu ,  Canxian Mu ,  Wenjun Wang ,  Jianwei Chen ,  Shuguang Wang

发明人： Shangzhong Liu ,  Canxian Mu ,  Wenjun Wang ,  Jianwei Chen ,  Shuguang Wang

IPC分类号： C07D239/52 ,  C07D239/34 ,  C07C67/343

CPC分类号： C07C67/31 ,  C07C67/343 ,  C07D239/34 ,  C07D239/52 ,  C07C69/734 ,  C07C69/738

摘要： Preparation method of a compound of general formula (I) comprises the following steps: (1) a compound of general formula (II) reacts with a formylating agent in an aprotic solvent at a temperature between −20° C. and 200° C. in the presence of a Lewis acid, then an organic base is added to promote the reaction to obtain an intermediate product; (2) the above intermediate product reacts with a methylating agent in the presence of an alkali at a temperature between −20° C. and 100° C. to obtain the compound of formula (I).

摘要翻译： 通式（I）化合物的制备方法包括以下步骤：（1）通式（II）的化合物在-20℃至200℃的温度下，在非质子传递溶剂中与甲酰化剂反应。 在路易斯酸存在下，加入有机碱促进反应得到中间产物; （2）上述中间产物在碱存在下，在-20℃至100℃的温度下与甲基化剂反应，得到式（I）化合物。

公开(公告)号：US20210237394A1

公开(公告)日：2021-08-05

申请号：US16494431

申请日：2018-04-18

申请人： Lifan Huang ,  Shuguang Wang

发明人： Lifan Huang ,  Shuguang Wang

IPC分类号： B32B3/28 ,  B32B15/082 ,  G10K11/168 ,  F16F7/10

摘要： The invention provides an acoustic material structure and an assembly method of the acoustic radiation structure. The acoustic material structure comprises acoustic units which can be attached onto surfaces of acoustic radiation structures. Each acoustic unit comprises a thin sheet, an air cavity between the thin sheet and the surface of the sound radiation structure, and openings penetrating through the acoustic unit with one end connected to the cavity. The openings can reduce the spring effect of the fluid medium in the cavity, so that the acoustic units attached onto the surface of the sound radiation structure can provide low-frequency sound insulation effects. The acoustic unit may also include support bodies, mass blocks, and constraint bodies. The working frequencies of the acoustic unit can be regulated by the support bodies, mass blocks and constraint bodies. The acoustic material structure can effectively suppress sound radiation from low- and middle-frequency sound waves which have relatively larger wavelength under costs of small weight and space. Moreover, the acoustic material structure can enhance the exchange rate of the heat from the attached structure surfaces by the vibration of the thin sheet.

公开(公告)号：US08895725B2

公开(公告)日：2014-11-25

申请号：US13130130

申请日：2009-11-23

申请人： Shuguang Wang ,  Jin Zhong ,  Deyun Kong ,  Jue Hu ,  Bo Li ,  Wen Gao ,  Chunyan Gai ,  Changlong Zhuang ,  Haitao Mao

发明人： Shuguang Wang ,  Jin Zhong ,  Deyun Kong ,  Jue Hu ,  Bo Li ,  Wen Gao ,  Chunyan Gai ,  Changlong Zhuang ,  Haitao Mao

IPC分类号： A61K31/192 ,  C09B1/473 ,  A61K36/708 ,  A61K36/74 ,  A61K31/185 ,  A61K31/704 ,  A61K31/122 ,  A61K31/7004 ,  A61K36/482

CPC分类号： A61K31/122 ,  A61K31/185 ,  A61K31/192 ,  A61K31/7004 ,  A61K31/704 ,  A61K36/482 ,  A61K36/708 ,  A61K36/74

摘要： Use of 9,10-anthraquinone compounds of formula (I) or pharmaceutical salts thereof or plant extracts containing said compounds in the preparation of anti-HCV medicaments is disclosed, in which Y1 are Y2 are independently hydrogen, hydroxyl or groups of formula (II); and R1, R2, R3, R4, R5 and R6 are independently hydrogen, hydroxyl, carboxyl, cyano group, nitro group, groups of formula (III) or groups selected from those substituted or unsubstituted groups: amino, C1-C6 aliphatic hydrocarbon, C3-C7 cyclic aliphatic hydrocarbon, C1-C6 alkoxy, C2-C7 carbalkoxy, C1-C4 acyloxy, C6-C20 aryl, or 5 to 7 members heterocyclic or benzoheterocyclic thereof; or R5 and R6 form the group of formula (IV). The compounds of present invention are cheap, safe and effective because that they mostly come from traditional Chinese medicines and have better anti-HCV effects and lighter side effects.

摘要翻译： 公开了在制备抗HCV药物中使用式（I）的9,10-蒽醌化合物或其药用盐或含有所述化合物的植物提取物，其中Y 1为Y 2独立地为氢，羟基或式（II ）; 并且R 1，R 2，R 3，R 4，R 5和R 6独立地是氢，羟基，羧基，氰基，硝基，式（III）的基团或选自那些取代或未取代的基团的基团：氨基，C 1 -C 6脂族烃， C 3 -C 7环脂族烃，C 1 -C 6烷氧基，C 2 -C 7烷酰氧基，C 1 -C 4酰氧基，C 6 -C 20芳基或5至7元杂环或苯并杂环; 或R 5和R 6形成式（IV）的基团。 本发明化合物廉价，安全有效，因为它们主要来自中药，抗HCV效果更好，副作用更轻。

公开(公告)号：US20110224414A1

公开(公告)日：2011-09-15

申请号：US13130130

申请日：2009-11-23

申请人： Shuguang Wang ,  Jin Zhong ,  Deyun Kong ,  Jue Hu ,  Bo Li ,  Wen Gao ,  Chunyan Gai ,  Changiong Zhuang ,  Haitao Mao

发明人： Shuguang Wang ,  Jin Zhong ,  Deyun Kong ,  Jue Hu ,  Bo Li ,  Wen Gao ,  Chunyan Gai ,  Changiong Zhuang ,  Haitao Mao

IPC分类号： C07H15/24 ,  C07C309/44 ,  C07C49/675

CPC分类号： A61K31/122 ,  A61K31/185 ,  A61K31/192 ,  A61K31/7004 ,  A61K31/704 ,  A61K36/482 ,  A61K36/708 ,  A61K36/74

摘要： Use of 9,10-anthraquinone compounds of formula (I) or pharmaceutical salts thereof or plant extracts containing said compounds in the preparation of anti-HCV medicaments is disclosed, in which Y1 are Y2 are independently hydrogen, hydroxyl or groups of formula (II); and R1, R2, R3, R4, R5 and R6 are independently hydrogen, hydroxyl, carboxyl, cyano group, nitro group, groups of formula (III) or groups selected from those substituted or unsubstituted groups: amino, C1-C6 aliphatic hydrocarbon, C3-C7 cyclic aliphatic hydrocarbon, C1-C6 alkoxy, C2-C7 carbalkoxy, C1-C4 acyloxy, C6-C20 aryl, or 5 to 7 members heterocyclic or benzoheterocyclic thereof; or R5 and R6 form the group of formula (IV). The compounds of present invention are cheap, safe and effective, because that they mostly conic from traditional Chinese medicines and have better anti-HCV effects and lighter side effects.

摘要翻译： 公开了在制备抗HCV药物中使用式（I）的9,10-蒽醌化合物或其药用盐或含有所述化合物的植物提取物，其中Y 1为Y 2独立地为氢，羟基或式（II ）; 并且R 1，R 2，R 3，R 4，R 5和R 6独立地是氢，羟基，羧基，氰基，硝基，式（III）的基团或选自那些取代或未取代的基团的基团：氨基，C 1 -C 6脂族烃， C 3 -C 7环脂族烃，C 1 -C 6烷氧基，C 2 -C 7烷酰氧基，C 1 -C 4酰氧基，C 6 -C 20芳基或5至7元杂环或苯并杂环; 或R 5和R 6形成式（IV）的基团。 本发明化合物廉价，安全有效，因为它们大多是中药复方，抗HCV效果更好，副作用更轻。