发明授权
US08299129B2 Peptide lipid-containing carrier and method for introducing compound into cells using same
有权
含肽脂质的载体和使用其将化合物引入细胞的方法
- 专利标题： Peptide lipid-containing carrier and method for introducing compound into cells using same
- 专利标题（中）： 含肽脂质的载体和使用其将化合物引入细胞的方法
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申请号： US12281227申请日： 2006-03-01
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公开(公告)号： US08299129B2公开(公告)日： 2012-10-30
- 发明人: Kenichi Kusumoto , Itaru Hamachi , Kazumi Sasamoto , Tetsuyuki Akao , Munetaka Ishiyama , Takahiro Nagata , Chizu Ikeda , Takeshi Ido , Satoko Yamashita , Rieko Kuroda , Tomoyuki Ishikawa
- 申请人： Kenichi Kusumoto , Itaru Hamachi , Kazumi Sasamoto , Tetsuyuki Akao , Munetaka Ishiyama , Takahiro Nagata , Chizu Ikeda , Takeshi Ido , Satoko Yamashita , Rieko Kuroda , Tomoyuki Ishikawa
- 申请人地址： JP Fukuoka-shi JP Kyoto-shi JP Kamimashiki-gun
- 专利权人： Fukuoka Prefectural Government,Kyoto University,Dojindo Laboratories
- 当前专利权人： Fukuoka Prefectural Government,Kyoto University,Dojindo Laboratories
- 当前专利权人地址： JP Fukuoka-shi JP Kyoto-shi JP Kamimashiki-gun
- 代理机构： Leydig, Voit & Mayer, Ltd.
- 国际申请： PCT/JP2006/304514 WO 20060301
- 国际公布： WO2007/099650 WO 20070907
- 主分类号： A01N25/00
- IPC分类号： A01N25/00 ; A61K47/00 ; A61K38/06 ; C12N5/00 ; C12N5/02 ; C07K5/00 ; C07K7/00 ; C07K16/00 ; C07K17/00
摘要：
The present invention provides a carrier capable of highly efficiently introducing a compound into cells with low cytotoxicity, which contains peptide lipids represented by the following formula, and a method for introducing a compound into cells using the carrier: wherein R1 is an amino acid or peptide having 1-10 amino acid residues, R2 is a side chain of any amino acid, provided that R2 has a carboxyl group, the carboxyl group may be an ester with a hydrocarbon group having 1-30 carbon atoms, R3 is a hydrocarbon group having 1-30 carbon atoms.
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