发明授权
- 专利标题: Salt of isoquinoline compound and crystal thereof
- 专利标题(中): 异喹啉化合物的盐及其结晶
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申请号: US12672784申请日: 2008-08-08
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公开(公告)号: US08309573B2公开(公告)日: 2012-11-13
- 发明人: Masakazu Fujio , Toshihiko Tanaka , Hisao Takayanagi , Hiroyuki Satoh , Takanori Ito
- 申请人: Masakazu Fujio , Toshihiko Tanaka , Hisao Takayanagi , Hiroyuki Satoh , Takanori Ito
- 申请人地址: JP Osaka-shi
- 专利权人: Mitsubishi Tanabe Pharma Corporation
- 当前专利权人: Mitsubishi Tanabe Pharma Corporation
- 当前专利权人地址: JP Osaka-shi
- 代理机构: Leydig, Voit & Mayer, Ltd.
- 优先权: JP2007/208693 20070810
- 国际申请: PCT/JP2008/064289 WO 20080808
- 国际公布: WO2009/022642 WO 20090219
- 主分类号: A61K31/47
- IPC分类号: A61K31/47 ; C07D217/22
摘要:
The invention provides a salt of (R)-3-[2-(2-hydroxymethylpyrrolidin-1-yl)ethyl]-5-methyl-2H-isoquinolin-1-one and a crystal thereof. (R)-3-[2-(2-Hydroxymethylpyrrolidin-1-ypethyl]-5-methyl-2H-1-isoquinolin-1-one monophosphate is a compound which is chemically stable, has high solubility, and shows less weight change due to humidity as compared to a free form and monohydrochloride dihydrate, and is superior as a bulk drug for pharmaceutical products.
公开/授权文献
- US20110130419A1 NOVEL SALT OF ISOQUINOLINE COMPOUND AND CRYSTAL THEREOF 公开/授权日:2011-06-02
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