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公开(公告)号:US5789448A
公开(公告)日:1998-08-04
申请号:US619519
申请日:1996-06-25
申请人: Yasunori Kitano , Haruki Inokawa , Hisao Takayanagi , Tamaki Yano , Hiroe Umeki , Hiroto Hara
发明人: Yasunori Kitano , Haruki Inokawa , Hisao Takayanagi , Tamaki Yano , Hiroe Umeki , Hiroto Hara
IPC分类号: C07C59/90 , C07C69/738 , C07C225/16 , C07C225/20 , C07C229/44 , C07C235/78 , C07C255/40 , C07C255/41 , C07C255/42 , C07C255/43 , C07C255/56 , C07C317/28 , C07C323/29 , C07C323/62 , C07D295/084 , C07D295/104 , C07D295/125 , C07D295/135 , C07D295/145 , C07D333/34 , A61K31/165 , C07C235/76
CPC分类号: C07D295/092 , C07C225/16 , C07C225/20 , C07C229/44 , C07C235/78 , C07C255/40 , C07C255/41 , C07C255/42 , C07C255/43 , C07C255/56 , C07C317/28 , C07C323/29 , C07C323/62 , C07C59/90 , C07C69/738 , C07D295/104 , C07D295/125 , C07D295/135 , C07D295/145 , C07D333/34
摘要: Disclosed is a benzoylethylene derivative represented by the following formula (I) or a salt thereof. ##STR1## R.sup.1 to R.sup.5 : a hydrogen atom, --OR.sup.9 (R.sup.9 : a hydrogen atom, a C.sub.1 -C.sub.5 alkyl group, etc.), etc., R.sup.6 : a hydrogen atom, a C.sub.1 -C.sub.5 alkyl group, etc., R.sup.7 : a hydrogen atom, a cyano group, a C.sub.1 -C.sub.5 alkyl group, --SO.sub.q R.sup.15 (q: 0, 1, 2, R.sup.15 : a thienyl group, a phenyl group, etc.) etc., R.sup.8 : a cyano group, --CR.sup.22 R.sup.23 X (R.sup.22, R.sup.23 : a hydrogen atom, a C.sub.1 -C.sub.5 alkyl group, etc., X: --NR.sup.24 R.sup.25 (R.sup.24, R.sup.25 : a C.sub.1 -C.sub.5 alkyl group, etc., an alkylene group by combining, etc.)), etc. The benzoylethylene derivative of the present invention has potent tyrosine kinase inhibiting activity and cancer cell growth inhibiting activity. The tyrosine kinase inhibitor of the present invention is useful as a carcinostatic agent.
摘要翻译: PCT No.PCT / JP95 / 01475 Sec。 371日期1996年6月25日第 102(e)日期1996年6月25日PCT提交1995年7月25日PCT公布。 出版物WO96 / 03364 日期1996年2月8日公开是由下式(I)表示的苯并芘衍生物或其盐。 (I)R 1至R 5:氢原子,-OR 9(R 9:氢原子,C 1 -C 5烷基等)等,R 6:氢原子,C 1 -C 5烷基, 等等,R7:氢原子,氰基,C1-C5烷基,-SOqR15(q:0,1,2,R15:噻吩基,苯基等)等,R8:a 氰基,-CR 22 R 23 X(R 22,R 23:氢原子,C 1 -C 5烷基等,X:-NR 24 R 25(R 24,R 25:C 1〜C 5烷基等,通过组合的亚烷基等) ))等。本发明的苯甲基乙烯衍生物具有强的酪氨酸激酶抑制活性和癌细胞生长抑制活性。 本发明的酪氨酸激酶抑制剂可用作制癌剂。
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公开(公告)号:US5387142A
公开(公告)日:1995-02-07
申请号:US974115
申请日:1992-11-10
申请人: Hisao Takayanagi , Yasuo Funami
发明人: Hisao Takayanagi , Yasuo Funami
CPC分类号: F02B61/045 , B63H21/265
摘要: A power steering device for steering an outboard engine on a small boat has a hydraulic cylinder unit for angularly moving a steering arm of the outboard engine, the hydraulic cylinder unit having a piston rod connected to the steering arm, and a directional control spool valve for supplying a hydraulic pressure to the hydraulic cylinder unit to move the piston rod. A control cable controls the directional control spool valve in response to operation of a steering wheel. The control cable has a core having an end coupled to the piston rod and a sheath covering the core and having an end coupled to the spool of the directional control spool valve. The hydraulic cylinder unit has a cylinder divided by a piston into a first oil chamber through which the piston rod extends and a second oil chamber remote from the piston rod. The directional control spool valve has an oil passage which interconnects the first and second oil chambers when the directional control valve supplies the hydraulic pressure to the second oil chamber.
摘要翻译: 一种用于在小型船上转向舷外发动机的动力转向装置具有液压缸单元,用于使外侧发动机的转向臂成角度地移动,液压缸单元具有连接到转向臂的活塞杆,以及一个方向控制滑阀, 向液压缸单元供应液压以移动活塞杆。 响应于方向盘的操作,控制线缆控制方向控制滑阀。 控制电缆具有一端连接到活塞杆的芯部和一个覆盖芯体的护套,并具有一端部连接至方向控制滑阀的阀芯。 液压缸单元具有由活塞分隔成活塞杆延伸的第一油室和远离活塞杆的第二油室的圆筒。 方向控制滑阀具有油路,当方向控制阀向第二油室供应液压时,该通道将第一和第二油室相互连接。
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公开(公告)号:US5304661A
公开(公告)日:1994-04-19
申请号:US44602
申请日:1993-04-09
IPC分类号: C07C33/02 , C07C43/178 , C07C43/315 , C07C45/44 , C07C45/51 , C07C45/63 , C07C45/67 , C07C47/21 , C07C47/24 , C07C47/263 , C07C47/277 , C07C49/203 , C07C49/227 , C07C49/24 , C07C49/255 , C07C49/587 , C07C69/007 , C07C69/738 , C07C255/07 , C07C255/10 , C07C255/15 , C07C255/46 , C07C309/65 , C07D309/06 , C07D309/12 , C07F7/18 , C07D315/00
CPC分类号: C07F7/1856 , C07C255/07 , C07C255/10 , C07C255/15 , C07C255/46 , C07C309/65 , C07C33/02 , C07C43/178 , C07C43/315 , C07C45/44 , C07C45/512 , C07C45/516 , C07C45/63 , C07C45/673 , C07C45/676 , C07C47/21 , C07C47/24 , C07C47/263 , C07C47/277 , C07C49/203 , C07C49/227 , C07C49/24 , C07C49/255 , C07C49/587 , C07C69/007 , C07C69/738 , C07D309/06 , C07D309/12 , C07F7/1852 , C07C2101/18
摘要: Acyclic terpene compounds useful as intermediates for producing sarcophytol A which have an anti-carcinogenic promotor activity and anti-tumor activity, which compounds are shown by the general formula (I): ##STR1##
摘要翻译: 用于制备具有抗致癌促进剂活性和抗肿瘤活性的唾液酸A的中间体的无环萜烯化合物,该化合物由通式(I)表示:(*化学结构*)(I)
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公开(公告)号:US4769480A
公开(公告)日:1988-09-06
申请号:US896961
申请日:1986-08-15
申请人: Yoshiharu Morita , Naoshi Imaki , Hisao Takayanagi , Tadashi Shirasaka , Tetsuro Shimpuku , Yuki Takuma , Mari Oishi
发明人: Yoshiharu Morita , Naoshi Imaki , Hisao Takayanagi , Tadashi Shirasaka , Tetsuro Shimpuku , Yuki Takuma , Mari Oishi
IPC分类号: C07D317/50 , C07D317/64 , C07D491/04 , C07D491/056
CPC分类号: C07D491/04 , C07D317/64
摘要: There is provided a novel benzylamine derivative of the formula I: ##STR1## wherein R.sup.1 represents a hydrogen atom or a methyl group, X represents a hydrogen atom, a methyl group or a tosyl group, and Y represents a hydrogen atom, a methyl group or ##STR2## in which R.sup.2 and R.sup.3 being identical or different from each other represent independently a lower alkyl group.
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公开(公告)号:US4746747A
公开(公告)日:1988-05-24
申请号:US901367
申请日:1986-08-28
IPC分类号: C07D317/44 , C07D317/00 , C07D317/48 , C07D317/64 , C07D405/06 , C07D491/04 , C07D491/056
CPC分类号: C07D405/06 , C07D317/64 , C07D491/04
摘要: There is provided a novel anisole derivative represented by the following formula (I): ##STR1## wherein A to D are defined as follows: (1) A, B and C are each a hydrogen atom, and D represents --OH, a halogen atom, --CO.sub.2 R.sup.1 of which R.sup.1 represents a lower alkyl group, --SO.sub.2 R.sup.2 of which R.sup.2 represents a lower alkyl group, or ##STR2## or (2) A and C are each a hydrogen atom, B is --OH, and D represents --CO.sub.2 R.sup.3 of which R.sup.3 represents a lower alkyl group; or(3) A is a hydrogen atom, B and C form an oxo group .dbd.O together, and D represents --CO.sub.2 R.sup.4 of which R.sup.4 represents a lower alkyl group; or(4) B and C are each a hydrogen atom, D is a halogen atom, and A represents --CHO.
摘要翻译: 提供由下式(I)表示的新型苯甲醚衍生物:其中A至D定义如下:(1)A,B和C各自为氢原子,D表示-OH ,卤素原子,其中R 1表示低级烷基的-CO 2 R 1,其中R 2表示低级烷基的-SO 2 R 2,或(2)A和C各自为氢原子,B为-OH,和 D表示其中R 3表示低级烷基的-CO 2 R 3; 或(3)A是氢原子,B和C一起形成氧代基= O,D表示-CO 2 R 4,其中R4代表低级烷基; 或(4)B和C各自为氢原子,D为卤素原子,A为-CHO。
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公开(公告)号:US06328616B1
公开(公告)日:2001-12-11
申请号:US09616396
申请日:2000-07-14
IPC分类号: B63H5125
CPC分类号: B63H20/10 , F02B61/045
摘要: In a trim-tilt device for a marine propulsion unit 20, a cylinder 41 of a cylinder device 21 is covered with a tank 28 constituting a hydraulic fluid supply/discharge device 22 and a relief valve 131 is opened when hydraulic pressure of the tank 25 becomes higher than a fixed value, so that hydraulic fluid of the tank 25 can be relieved for the second tilt chamber 32B.
摘要翻译: 在用于船用推进单元20的装饰倾斜装置中,气缸装置21的气缸41被构成液压流体供给/排出装置22的油箱28覆盖,并且当油箱25的液压压力时,溢流阀131打开 变得高于固定值,从而能够释放第二倾斜室32B中的罐25的液压流体。
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公开(公告)号:US5514711A
公开(公告)日:1996-05-07
申请号:US369263
申请日:1995-01-05
申请人: Yasunori Kitano , Hisao Takayanagi , Koichi Sugawara , Hiroto Hara , Hideo Nakamura , Toshiko Oshino
发明人: Yasunori Kitano , Hisao Takayanagi , Koichi Sugawara , Hiroto Hara , Hideo Nakamura , Toshiko Oshino
IPC分类号: A61K31/16 , A61K31/165 , A61K31/255 , A61K31/275 , A61P35/00 , C07C45/45 , C07C45/54 , C07C45/56 , C07C45/71 , C07C47/575 , C07C49/248 , C07C49/835 , C07C49/84 , C07C59/48 , C07C69/73 , C07C69/84 , C07C235/38 , C07C255/36 , C07C255/40 , C07C255/41 , C07C255/42 , C07C255/56 , C07C255/57 , C07C255/58 , C07C317/46 , C07C255/34
CPC分类号: C07C45/45 , C07C255/40 , C07C255/41 , C07C317/46 , C07C45/54 , C07C45/562 , C07C45/71 , C07C47/575 , C07C49/835 , C07C49/84
摘要: Styrene derivatives of the following general formula (I): ##STR1## or pharmaceutically acceptable salts thereof. A pharmaceutical composition useful as anticancer agent, which comprises the above compound as an essential component, is also provided.
摘要翻译: 下列通式(I)的苯乙烯衍生物:其中(I)或其药学上可接受的盐。 还提供了可用作抗癌剂的药物组合物,其包含上述化合物作为必需组分。
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公开(公告)号:US5354874A
公开(公告)日:1994-10-11
申请号:US159145
申请日:1993-11-30
IPC分类号: C07C33/02 , C07C43/178 , C07C43/315 , C07C45/44 , C07C45/51 , C07C45/63 , C07C45/67 , C07C47/21 , C07C47/24 , C07C47/263 , C07C47/277 , C07C49/203 , C07C49/227 , C07C49/24 , C07C49/255 , C07C49/587 , C07C69/007 , C07C69/738 , C07C255/07 , C07C255/10 , C07C255/15 , C07C255/46 , C07C309/65 , C07D309/06 , C07D309/12 , C07F7/18 , C07C69/734 , C07D315/00
CPC分类号: C07F7/1856 , C07C255/07 , C07C255/10 , C07C255/15 , C07C255/46 , C07C309/65 , C07C33/02 , C07C43/178 , C07C43/315 , C07C45/44 , C07C45/512 , C07C45/516 , C07C45/63 , C07C45/673 , C07C45/676 , C07C47/21 , C07C47/24 , C07C47/263 , C07C47/277 , C07C49/203 , C07C49/227 , C07C49/24 , C07C49/255 , C07C49/587 , C07C69/007 , C07C69/738 , C07D309/06 , C07D309/12 , C07F7/1852 , C07C2101/18
摘要: Acyclic terpene compounds useful as intermediates for producing sarcophytol A which have an anti-carcinogenic promotor activity and anti-tumor activity, which compounds are shown by the general formula (I): ##STR1##
摘要翻译: 用于制备具有抗致癌促进剂活性和抗肿瘤活性的唾液酸A的中间体的无环萜烯化合物,该化合物由通式(I)表示:
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公开(公告)号:US5324869A
公开(公告)日:1994-06-28
申请号:US44601
申请日:1993-04-09
IPC分类号: C07C33/02 , C07C43/178 , C07C43/315 , C07C45/44 , C07C45/51 , C07C45/63 , C07C45/67 , C07C47/21 , C07C47/24 , C07C47/263 , C07C47/277 , C07C49/203 , C07C49/227 , C07C49/24 , C07C49/255 , C07C49/587 , C07C69/007 , C07C69/738 , C07C255/07 , C07C255/10 , C07C255/15 , C07C255/46 , C07C309/65 , C07D309/06 , C07D309/12 , C07F7/18 , C07C33/044
CPC分类号: C07C33/02 , C07C255/07 , C07C255/10 , C07C255/15 , C07C255/46 , C07C309/65 , C07C43/178 , C07C43/315 , C07C45/44 , C07C45/512 , C07C45/516 , C07C45/63 , C07C45/673 , C07C45/676 , C07C47/21 , C07C47/24 , C07C47/263 , C07C47/277 , C07C49/203 , C07C49/227 , C07C49/24 , C07C49/255 , C07C49/587 , C07C69/007 , C07C69/738 , C07D309/06 , C07D309/12 , C07F7/1852 , C07F7/1856 , C07C2101/18
摘要: Acyclic terpene compounds useful as intermediates or producing sarcophytol A which have an anti-carcinogenic promotor activity and anti-tumor activity, which compounds are shown by the general formula (I): ##STR1##
摘要翻译: 可用作中间体或生产具有抗致癌促进剂活性和抗肿瘤活性的唾液酸A的无环萜烯化合物,该化合物由通式(I)表示:其中R是式 :
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公开(公告)号:US5292911A
公开(公告)日:1994-03-08
申请号:US849576
申请日:1992-03-10
IPC分类号: C07C33/42 , C07C45/29 , C07C45/51 , C07C47/24 , C07C49/587 , C07C69/65 , C07C255/16 , C07C255/46 , C07F7/18 , C07F7/10 , C07C69/52
CPC分类号: C07F7/1856 , C07C255/16 , C07C255/46 , C07C33/423 , C07C45/298 , C07C45/511 , C07C45/512 , C07C47/24 , C07C49/587 , C07C69/65 , C07F7/1852 , C07C2101/18
摘要: Novel monocyclic terpene derivative of the formula: ##STR1## wherein R is hydrogen atom, trimethylsilyl group or 1-ethoxyethyl group, and novel intermediates therefor. The terpene derivative (I) is a useful intermediate for preparing Sarcophytol A having an anti-carcinogenesis promoter activity and an antitumor activity.
摘要翻译: 下式的新型单环萜衍生物:其中R是氢原子,三甲基甲硅烷基或1-乙氧基乙基,及其新颖的中间体。 萜烯衍生物(I)是制备具有抗致癌作用启动子活性和抗肿瘤活性的Sarcophytol A的有用中间体。
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