发明授权
- 专利标题： Methods and compositions for enhancing the efficacy and specificity of RNA silencing
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申请号： US12748937申请日： 2010-03-29
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公开(公告)号： US08309705B2公开(公告)日： 2012-11-13
- 发明人: Phillip D. Zamore , Gyorgy Hutvagner , Dianne Schwarz , Martin Simard
- 申请人： Phillip D. Zamore , Gyorgy Hutvagner , Dianne Schwarz , Martin Simard
- 申请人地址： US MA Boston
- 专利权人： University of Massachusetts
- 当前专利权人： University of Massachusetts
- 当前专利权人地址： US MA Boston
- 代理机构： Nelson Mullins Riley & Scarborough LLP
- 代理商 Debra J. Milasincic, Esq.
- 主分类号： C07H21/00
- IPC分类号： C07H21/00 ; C07H21/02 ; C07H21/04 ; C12P19/34
摘要：
The present invention provides methods of enhancing the efficacy and specificity of RNA silencing. The invention also provides compositions for mediating RNA silencing. In particular, the invention provides siRNAs, siRNA-like molecules, shRNAs, vectors and transgenes having improved specificity and efficacy in mediating silencing of a target gene. Therapeutic methods are also featured.
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