发明授权
- 专利标题: Chimeric vaccines
- 专利标题(中): 嵌合疫苗
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申请号: US10474371申请日: 2002-04-05
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公开(公告)号: US08318173B2公开(公告)日: 2012-11-27
- 发明人: Thomas August , Ernesto Marques, Jr.
- 申请人: Thomas August , Ernesto Marques, Jr.
- 申请人地址: US MD Baltimore
- 专利权人: The John Hopkins University
- 当前专利权人: The John Hopkins University
- 当前专利权人地址: US MD Baltimore
- 代理机构: Edwards Wildman Palmer LLP
- 代理商 Peter F. Corless; Andrew W. Shyjan, Esq.
- 国际申请: PCT/US02/10757 WO 20020405
- 国际公布: WO02/080851 WO 20021017
- 主分类号: C07K16/00
- IPC分类号: C07K16/00 ; C12P21/08 ; A61K39/00
摘要:
The invention provides chimeric proteins and nucleic acids encoding these which can be used to generate vaccines against selected antigens. In one aspect, a chimeric protein comprises an antigen sequence and a domain for trafficking the protein to an endosomal compartment, irrespective of whether the antigen is derived from a membrane or non-membrane protein. In one preferred aspect, the trafficking domain comprises a lumenal domain of a LAMP polypeptide. Alternatively, or additionally, the chimeric protein comprises a trafficking domain of an endocytic receptor (e.g., such as DEC-205 or gp200-MR6). The vaccines (DNA, RNA or protein) can be used to modulate or enhance an immune response against any kind of antigen. In one preferred aspect, the invention provides a method for treating a patient with cancer by providing a chimeric protein comprising a cancer-specific antigen or a nucleic acid encoding the protein to the patient.
公开/授权文献
- US20040157307A1 Chimeric vaccines 公开/授权日:2004-08-12