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公开(公告)号：US09358924B1
公开(公告)日：2016-06-07
申请号：US12776137
申请日：2010-05-07
CPC分类号： G01V13/00 , B60Q9/00 , G01V11/002 , G06F17/5009 , G06F17/5095 , Y02T10/82
摘要： A system and methods are disclosed for providing integrated software development environment for the design, verification and validation of advanced automotive safety systems. The system allows automotive software to be developed on a host computer using a collection of computer programs running simultaneously as processes and synchronized by a central process. The software disclosed uses separate synchronized processes, permitting signals from disparate sources to be generated by a simulation running on the host computer or from actual sensors and data bus signals coming from and going to actual vehicle hardware which is connected to their bus counterparts in the host computer on a real-time basis. The methods provide a data model that first extends the capabilities of the physical data model and then translates, gates, optimizes, fuses, filters and manages the physical representation of the logical model into a state estimation of the situation around the vehicle.
摘要翻译： 公开了一种系统和方法，用于为高级汽车安全系统的设计，验证和验证提供集成的软件开发环境。 该系统允许在主计算机上开发汽车软件，该计算机程序将作为进程同时运行并由中央过程进行同步。 公开的软件使用单独的同步过程，允许来自不同来源的信号通过在主计算机上运行的仿真或来自实际传感器和数据总线信号来产生，所述实际传感器和数据总线信号来自和去往连接到其主机中的总线对应物的实际车辆硬件 电脑在实时的基础上。 这些方法提供了一种数据模型，其首先扩展了物理数据模型的能力，然后将逻辑模型的物理表示转换，门控，优化，融合，过滤和管理到对车辆周围情况的状态估计。
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2.发明申请HUMAN IMMUNODEFICIENCY VIRUS (HIV-1) HIGHLY CONSERVED AND LOW VARIANT SEQUENCES AS TARGETS FOR VACCINE AND DIAGNOSTIC APPLICATIONS 审中-公开人类免疫缺陷病毒（HIV-1）高度保守和低变异序列作为疫苗和诊断应用的目标公开(公告)号：US20130195904A1
公开(公告)日：2013-08-01
申请号：US13520388
申请日：2011-01-04
IPC分类号： A61K39/21
CPC分类号： A61K39/21 , A61K39/00 , C07K14/005 , C12N2740/16022 , C12N2740/16034
摘要： We identified regions of the HIV-1 proteome with high conservation, and low variant incidence. Such highly conserved sequences have direct relevance to the development of new-generation vaccines and diagnostic applications. The immune relevance of these sequences was assessed by their correlation to previously reported human T-cell epitopes and to recently identified human HIV-1 T-cell epitopes (identified using HLA transgenic mice). We identified (a) sequences specific to HIV-1 with no shared identity to other viruses and organisms, and (b) sequences that are specific to primate lentivirus group, with multiclade HIV-1 conservation.
摘要翻译： 我们确定了具有高度保守性和低变异发生率的HIV-1蛋白质组的区域。 这种高度保守的序列与新一代疫苗和诊断应用的发展直接相关。 这些序列的免疫相关性通过与之前报道的人T细胞表位和最近鉴定的人HIV-1 T细胞表位（使用HLA转基因小鼠鉴定）的相关性来评估。 我们确定（a）HIV-1特异性序列，与其他病毒和生物体无共享身份，（b）具有多重HIV-1保护的灵长类慢病毒组特异性序列。
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公开(公告)号：US5972707A
公开(公告)日：1999-10-26
申请号：US890599
申请日：1997-07-09
申请人： Krishnendu Roy , Hai-Quan Mao , Vu L. Truong , Thomas August , Kam W. Leong
发明人： Krishnendu Roy , Hai-Quan Mao , Vu L. Truong , Thomas August , Kam W. Leong
CPC分类号： A61K9/5161 , A61K47/4823 , A61K47/48238 , A61K47/48292 , A61K47/48561 , A61K47/48876 , A61K9/167 , A61K9/5169 , A61K9/5192 , B82Y5/00 , C12N15/88 , A61K48/00 , Y10S977/808 , Y10S977/906 , Y10S977/915 , Y10S977/916 , Y10S977/92
摘要： A gene delivery system is made of enzymatically degradable polymeric cation and nucleic acid (DNA or RNA) nanospheres optionally with a linking moiety or a targeting ligand attached to the surface. The delivery system can be made by a simple method of coacervation. Targeting ligands can be attached to the nanosphere directly or via a linking moiety. The linkage design allows the attachment of any molecule onto the nanosphere surface including antibodies, cell adhesion molecules, hormones and other cell-specific ligands.
摘要翻译： 基因递送系统由可酶降解的聚合阳离子和核酸（DNA或RNA）纳米球制成，任选地具有连接部分或连接到表面的靶向配体。 输送系统可以通过简单的凝聚方法制成。 靶向配体可以直接或通过连接部分连接到纳米球。 连接设计允许将任何分子附着到纳米球表面，包括抗体，细胞粘附分子，激素和其他细胞特异性配体。
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公开(公告)号：US5633234A
公开(公告)日：1997-05-27
申请号：US6845
申请日：1993-01-22
IPC分类号： C12N15/09 , A61K39/00 , A61K48/00 , A61P37/00 , C07K5/107 , C07K7/06 , C07K7/08 , C07K14/705 , C07K14/74 , C07K19/00 , C12N5/10 , C12P21/02 , A61K31/70 , C12N15/62
CPC分类号： C07K14/70539 , C07K14/705 , A61K39/00 , C07K2319/06 , C07K2319/40 , Y10S530/806
摘要： The inventors have discovered a targeting signal that will direct proteins to the endosomal/lysosomal compartment, and they have demonstrated that chimeric proteins containing a luminal antigenic domain and a cytoplasmic endosomal/lysosomal targeting signal will effectively target antigens to that compartment, where the antigenic domain is processed and peptides from it are presented on the cell surface in association with major histocompatibility (MHC) class II molecules. Chimeric DNA encoding the antigen of interest, linked to an endosomal/lysosomal targeting sequence, inserted in an immunization vector, can introduce the chimeric genes into cells, where the recombinant antigens are expressed and targeted to the endosomal/lysosomal compartment. As a result, the antigens associate more efficiently with MHC class II molecules, providing enhanced in vivo stimulation of CD4.sup.+ T cells specific for the recombinant antigen. Delivering antigens to an endosomal/lysosomal compartment by means of chimeric constructs containing such lysosomal targeting signals will be of value in any vaccination or immunization strategy that seeks to stimulate CD4.sup.+ MHC class II restricted immune responses.
摘要翻译： 本发明人已经发现了将蛋白质引导到内体/溶酶体区室的靶向信号，并且他们已经证明含有腔内抗原结构域和细胞质内体/溶酶体靶向信号的嵌合蛋白将有效地将抗原靶向该区室，其中抗原结构域 被处理，并且来自它的肽与主要组织相容性（MHC）II类分子相关联地呈现在细胞表面上。 编码与插入免疫载体中的内体/溶酶体靶向序列连接的感兴趣的抗原的嵌合DNA可将嵌合基因导入细胞，其中重组抗原被表达并靶向内体/溶酶体区室。 结果，抗原更有效地与MHC II类分子相关联，提供对重组抗原特异性的CD4 + T细胞的增强的体内刺激。 通过含有这样的溶酶体靶向信号的嵌合构建体将抗原递送至内体/溶酶体区域将在寻求刺激CD4 + MHC II类限制性免疫应答的任何疫苗接种或免疫策略中是有价值的。
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公开(公告)号：US1114068A
公开(公告)日：1914-10-20
申请号：US1914840939
申请日：1914-05-25
申请人： THOMAS AUGUST
发明人： THOMAS AUGUST
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公开(公告)号：US08318173B2
公开(公告)日：2012-11-27
申请号：US10474371
申请日：2002-04-05
CPC分类号： A61K39/21 , A61K39/00 , A61K39/12 , A61K2039/53 , A61K2039/57 , C07H21/04 , C07K14/005 , C07K14/70596 , C07K2319/00 , C07K2319/03 , C07K2319/06 , C07K2319/40 , C12N7/00 , C12N15/62 , C12N15/86 , C12N2740/16234 , C12N2750/14143
摘要： The invention provides chimeric proteins and nucleic acids encoding these which can be used to generate vaccines against selected antigens. In one aspect, a chimeric protein comprises an antigen sequence and a domain for trafficking the protein to an endosomal compartment, irrespective of whether the antigen is derived from a membrane or non-membrane protein. In one preferred aspect, the trafficking domain comprises a lumenal domain of a LAMP polypeptide. Alternatively, or additionally, the chimeric protein comprises a trafficking domain of an endocytic receptor (e.g., such as DEC-205 or gp200-MR6). The vaccines (DNA, RNA or protein) can be used to modulate or enhance an immune response against any kind of antigen. In one preferred aspect, the invention provides a method for treating a patient with cancer by providing a chimeric protein comprising a cancer-specific antigen or a nucleic acid encoding the protein to the patient.
摘要翻译： 本发明提供嵌合蛋白质和编码这些蛋白质的核酸，其可用于产生针对所选抗原的疫苗。 在一个方面，嵌合蛋白包括抗原序列和用于将蛋白质运送到内体室的结构域，而不管抗原是源自膜还是非膜蛋白。 在一个优选的方面，所述贩运结构域包含LAMP多肽的内腔结构域。 或者或另外，嵌合蛋白质包含内吞受体（例如DEC-205或gp200-MR6）的贩运结构域。 疫苗（DNA，RNA或蛋白质）可用于调节或增强针对任何种类抗原的免疫应答。 在一个优选的方面，本发明提供了一种通过向患者提供包含癌特异性抗原或编码该蛋白的核酸的嵌合蛋白来治疗癌症患者的方法。
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公开(公告)号：US20120294879A1
公开(公告)日：2012-11-22
申请号：US13501339
申请日：2010-10-13
IPC分类号： A61K39/145 , C12N15/33 , C12N15/85 , C12N15/86 , C07K14/11 , C12P21/02 , C07K7/06 , A61P31/16 , C07K19/00 , C07K7/08 , C12N15/62 , C12N5/10
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/5154 , A61K2039/5156 , A61K2039/70 , C07K14/005 , C07K2319/00 , C12N2760/16122 , C12N2760/16134
摘要： Pandemic A(H1N1) continues its global spread, and vaccine production is a serious problem. Protection by current vaccines is limited by the mutational differences that rapidly accumulate in the circulating strains, especially in the virus surface proteins. New vaccine strategies are focusing at conserved regions of the viral internal proteins to produce T cell epitope-based vaccines. T cell responses have been shown to reduce morbidity and promote recovery in mouse models of influenza challenge. We previously reported 54 highly conserved sequences of NP, M1 and the polymerases of all human H1N1, H3N2, H1N2, and H5N1, and avian subtypes over the past 30 years. Sixty-three T cell epitopes elicited responses in HLA transgenic mice (A2, A24, B7, DR2, DR3 and DR4). These epitopes were compared to the 2007-2009 human H1N1 sequences to identify conserved and variant residues. Seventeen T cell epitopes of PB1, PB2, and M1 were selected as vaccine targets by analysis of sequence conservation and variability, functional avidity, non-identity to human peptides, clustered localization, and promiscuity to multiple HLA alleles. The vaccines composed of these epitopes, being highly conserved and temporally stable, would be useful for any avian or human influenza A virus.
摘要翻译： 大流行A（H1N1）继续全球蔓延，疫苗生产是一个严重的问题。 目前疫苗的保护受到循环菌株尤其是病毒表面蛋白质快速积累的突变差异的限制。 新的疫苗策略着重于病毒内部蛋白质的保守区域，以产生基于T细胞表位的疫苗。 已经显示T细胞应答降低发病率并促进小鼠流感病毒模型的恢复。 以前报道过去30年来，54种高度保守的NP，M1和所有人类H1N1，H3N2，H1N2和H5N1以及禽亚型的聚合酶序列。 六十三个T细胞表位在HLA转基因小鼠（A2，A24，B7，DR2，DR3和DR4）中引发反应。 将这些表位与2007-2009年人类H1N1序列进行比较，以鉴定保守和变异残基。 通过分析序列保守性和可变性，功能亲合力，与人肽的非同一性，聚类定位和对多个HLA等位基因的混杂，选择PB1，PB2和M1的17个T细胞表位作为疫苗靶。 由这些表位组成的高度保守和时间稳定的疫苗对于任何禽类或人类甲型流感病毒都是有用的。
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公开(公告)号：US1279177A
公开(公告)日：1918-09-17
申请号：US22744918
申请日：1918-04-09
申请人： THOMAS AUGUST
发明人： THOMAS AUGUST
CPC分类号： D05B35/062
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9.发明授权System and method for the configuration of an automotive vehicle with modeled sensors 有权用于配置具有模型传感器的机动车辆的系统和方法公开(公告)号：US08417490B1
公开(公告)日：2013-04-09
申请号：US12777608
申请日：2010-05-11
CPC分类号： G06F17/5095 , Y02T10/82
摘要： A system and methods are disclosed for providing integrated software development environment for the design, verification and validation of advanced automotive safety systems. The system allows automotive software to be developed on a host computer using a collection of computer programs running simultaneously as processes and synchronized by a central process. The software disclosed uses separate synchronized processes, permitting signals from disparate sources to be generated by a simulation running on the host computer or from actual sensors and data bus signals coming from and going to actual vehicle hardware which is connected to their bus counterparts in the host computer on a real-time basis. The methods disclosed are for providing an Algorithm Prototyping, Analysis and Test through an integrated framework for dynamic data modeling and application development.
摘要翻译： 公开了一种系统和方法，用于为高级汽车安全系统的设计，验证和验证提供集成的软件开发环境。 该系统允许在主计算机上开发汽车软件，该计算机程序将作为进程同时运行并由中央过程进行同步。 公开的软件使用单独的同步过程，允许来自不同来源的信号通过在主计算机上运行的仿真或来自实际传感器和数据总线信号来产生，所述实际传感器和数据总线信号来自和去往连接到其主机中的总线对应物的实际车辆硬件 电脑在实时的基础上。 所公开的方法是通过用于动态数据建模和应用开发的集成框架提供算法原型制作，分析和测试。
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10.发明申请FLAVIVIRUS SPECIES-SPECIFIC PEPTIDE TAGS FOR VACCINE AND DIAGNOSTIC USE 审中-公开FLAVIVIRUS物种特异性肽标签用于疫苗和诊断用途公开(公告)号：US20130011427A1
公开(公告)日：2013-01-10
申请号：US13516501
申请日：2010-12-16
CPC分类号： G01N33/56983 , A61K39/00 , C07K14/005 , C12N2770/24122 , G01N2333/18 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394 , Y02A50/53 , Y02A50/60
摘要： Flaviviruses represent an increasing global public health issue, with no prophylactic and therapeutic formulations currently available for many of them. The combination of factors such as evolutionary change, global warming and wide range of animal hosts suggest the possible occurrence of Flavivirus strains with greater distribution and human pathogenicity. There is, thus, a need for greater understanding of viral protein sequences that function in the human immune responses. The evolutionary diversity of the reported sequences of major flaviviruses, such as dengue virus, yellow fever virus, Japanese encephalitis virus, and West Nile virus were analyzed with a combination of experimental and bioinformatics methodologies. The analysis of all reported sequences revealed that these species-specific peptide tags are highly conserved and are potential T-cell epitopes due to correspondence to known or predicted epitopes. These peptide tags have direct relevance to the development of new-generation vaccines and diagnostic applications.
摘要翻译： 黄病毒属于日益严重的全球公共卫生问题，目前尚无许多预防和治疗方案。 诸如进化变化，全球变暖和广泛的动物宿主等因素的结合表明可能发生具有更大分布和人类致病性的黄病毒毒株。 因此，需要更多地了解在人免疫应答中起作用的病毒蛋白质序列。 通过实验和生物信息学方法的综合分析了报告的主要黄病毒序列的进化多样性，如登革热病毒，黄热病毒，日本脑炎病毒和西尼罗河病毒。 所有报道的序列的分析显示，这些物种特异性肽标签是高度保守的，并且由于与已知或预测的表位的对应而是潜在的T细胞表位。 这些肽标签与新一代疫苗和诊断应用的发展直接相关。
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