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发明授权
US08318447B2 Use of bitter taste receptor to screen for compounds that offset the bitter taste of chlorogenic lactone containing coffee compositions 有权
使用苦味受体筛选抵消含绿色内酯的咖啡组合物的苦味的化合物

Use of bitter taste receptor to screen for compounds that offset the bitter taste of chlorogenic lactone containing coffee compositions
摘要：
The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds, i.e., chlorogenic lactone compounds that contribute at least partially to the bitter taste of many coffee beverages. The present invention further relates to the use of these receptors in assays for identifying ligands that modulate the activation of these taste receptors by chlorogenic lactones and related compounds and which may be used as additives and/or removed from foods, beverages and medicinals in order to modify (block) T2R-associated bitter taste. A preferred embodiment is the use of the identified compounds as additives in coffee and coffee-flavored foods, beverages and medicinals.
摘要（中）：

本发明涉及T2R味觉受体家族中的特定人味受体对特定苦味化合物的反应的发现，即，至少部分地促成许多咖啡饮料的苦味的绿色内酯化合物。 本发明还涉及这些受体在测定中用于鉴定调节绿色内酯和相关化合物来调节这些味觉受体的活化并可以用作添加剂和/或从食品，饮料和药物中去除的配体的用途，以便 修改（阻断）T2R相关的苦味。 优选的实施方案是使用所鉴定的化合物作为咖啡和咖啡风味食品，饮料和药物中的添加剂。

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