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1.发明申请HUMAN T2R RECEPTORS FOR ACETAMINOPHEN, RANITIDINE, STRYCHNINE AND DENATONIUM AND RELATED ASSAYS FOR IDENTIFYING HUMAN BITTER TASTE MODULATORS 有权人类T2R受体对乙酰氨基酚，RANITIDINE，STRYCHNINE和DENATONIUM及相关测定用于鉴定人体双歧杆菌调味剂公开(公告)号：US20110281749A1
公开(公告)日：2011-11-17
申请号：US13052578
申请日：2011-03-21
申请人： XIAODONG LI , HONG XU , HUIXIAN TANG , QING LI
发明人： XIAODONG LI , HONG XU , HUIXIAN TANG , QING LI
IPC分类号： C40B30/04 , G01N21/64 , C12Q1/68 , G01N33/566
CPC分类号： G01N33/74 , G01N33/566 , G01N2333/726 , G01N2500/02
摘要： The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter ligands, i.e., acetaminophen, ranitidine, strychnine and denatonium. The present invention further relates to the use of these receptors in assays for identifying ligands that modulate the activation of these taste receptors and which may be used as additives in foods, beverages and medicinals for modifying (blocking) T2R-associated bitter taste.
摘要翻译： 本发明涉及T2R味觉受体家族中的特定人味受体对特定苦味配体即对乙酰氨基酚，雷尼替丁，士的宁和丹那铵的反应的发现。 本发明还涉及这些受体在用于鉴定调节这些味觉受体的活化的配体的测定中的用途，并且其可用作用于改变（阻断）T2R相关苦味的食品，饮料和药物中的添加剂。
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2.发明授权Identification of bitter ligands that specifically activate human T2R receptors and related assays for identifying human bitter taste modulators 有权识别特异性激活人T2R受体的苦配体和相关测定法，用于鉴定人类苦味调节剂公开(公告)号：US07883856B2
公开(公告)日：2011-02-08
申请号：US11766974
申请日：2007-06-22
申请人： Xiaodong Li , Hong Xu , Qing Li , Huixian Tang , Alexey Pronin
发明人： Xiaodong Li , Hong Xu , Qing Li , Huixian Tang , Alexey Pronin
IPC分类号： G01N33/566 , C07K14/705
CPC分类号： G01N33/566 , G01N33/5008 , G01N33/5023 , G01N2500/00 , G01N2500/10
摘要： The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds. Also, the invention relates to the discovery of specific hT2R9 alleles and their disparate activity in functional assays with the same biter ligands. The invention further relates to the use of these T2R receptors in assays for identifying ligands that modulate the activation of these taste receptors by specific bitter ligands and related compounds. These compounds may be used as additives and/or removed from foods, beverages, cosmetics and medicinals in order to modify (block) T2R-associated bitter taste. Also T2R ligands may be used as therapeutics to treat and modulate T2R associated gastrointestinal and metabolic functions as well as treat gastrointestinal and metabolic diseases such as eating disorders, food sensing, food absorption, obesity, diabetes, Crohn's disease, celiac disease, et al.
摘要翻译： 本发明涉及T2R味觉受体家族中的特定人味受体对特定苦味化合物的反应的发现。 此外，本发明还涉及特异性hT2R9等位基因的发现及其在具有相同配体配体的功能测定中的不同活性。 本发明还涉及这些T2R受体在用于鉴定通过特定的苦配体和相关化合物调节这些味觉受体的活化的配体的测定中的用途。 这些化合物可以用作添加剂和/或从食品，饮料，化妆品和药物中去除，以便改变（阻断）T2R相关的苦味。 也可以使用T2R配体作为治疗和调节T2R相关胃肠和代谢功能以及治疗胃肠道和代谢疾病如饮食失调，食物感觉，食物吸收，肥胖，糖尿病，克罗恩病，乳糜泻等的治疗剂。
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公开(公告)号：US20090203027A1
公开(公告)日：2009-08-13
申请号：US12413102
申请日：2009-03-27
申请人： Jon Elliot Adler , Alexey Pronin , Huixian Tang , Mark Zoller
发明人： Jon Elliot Adler , Alexey Pronin , Huixian Tang , Mark Zoller
IPC分类号： C12Q1/68 , G01N33/567 , G01N33/569
CPC分类号： C07K14/705 , A61K38/00
摘要： Isolated nucleic acids encoding T2R76 polypeptides, recombinantly expressed T2R76 polypeptides, heterologous expression systems for recombinant expression of T2R76 polypeptides, assay methods employing the same, and methods for altering taste perception via administration of a T2R76 modulator. These T22R76 polypeptides can be expressed alone or co-expressed with another T2R polypeptide, preferably a different human T2R polypeptide.
摘要翻译： 编码T2R76多肽的分离的核酸，重组表达的T2R76多肽，用于重组表达T2R76多肽的异源表达系统，使用该多肽的测定方法以及通过施用T2R76调节剂改变味觉的方法。 这些T22R76多肽可以单独表达或与另一个T2R多肽，优选不同的人T2R多肽共表达。
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公开(公告)号：US07517972B2
公开(公告)日：2009-04-14
申请号：US10628464
申请日：2003-07-29
申请人： Jon Elliot Adler , Huixian Tang , Alexey Pronin
发明人： Jon Elliot Adler , Huixian Tang , Alexey Pronin
CPC分类号： C07K14/705 , A61K38/00
摘要： Isolated nucleic acids encoding T2R76 polypeptides, recombinantly expressed T2R76 polypeptides, heterologous expression systems for recombinant expression of T2R76 polypeptides, assay methods employing the same, and methods for altering taste perception via administration of a T2R76 modulator. These T22R76 polypeptides can be expressed alone or co-expressed with another T2R polypeptide, preferably a different human T2R polypeptide.
摘要翻译： 编码T2R76多肽的分离的核酸，重组表达的T2R76多肽，用于重组表达T2R76多肽的异源表达系统，使用该多肽的测定方法以及通过施用T2R76调节剂改变味觉的方法。 这些T22R76多肽可以单独表达或与另一个T2R多肽，优选不同的人T2R多肽共表达。
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5.发明申请HUMAN T2R RECEPTORS FOR RANITIDINE, STRYCHNINE AND DENATONIUM AND RELATED ASSAYS FOR IDENTIFYING HUMAN BITTER TASTE MODULATORS 有权人类T2R受体的RANITIDINE，STRYCHNINE和DENATONIUM及相关测定用于鉴定人体双歧杆菌调味剂公开(公告)号：US20090087866A1
公开(公告)日：2009-04-02
申请号：US12166980
申请日：2008-07-02
申请人： Xiaodong LI , Hong Xu , Huixian Tang , Qing Li
发明人： Xiaodong LI , Hong Xu , Huixian Tang , Qing Li
IPC分类号： G01N33/567
CPC分类号： G01N33/74 , G01N33/566 , G01N2333/726 , G01N2500/02
摘要： The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter ligands, i.e., acetaminophen, ranitidine, strychnine and denatonium. The present invention further relates to the use of these receptors in assays for identifying ligands that modulate the activation of these taste receptors and which may be used as additives in foods, beverages and medicinals for modifying (blocking) T2R-associated bitter taste.
摘要翻译： 本发明涉及T2R味觉受体家族中的特定人味受体对特定苦味配体即对乙酰氨基酚，雷尼替丁，士的宁和丹那铵的反应的发现。 本发明还涉及这些受体在用于鉴定调节这些味觉受体的活化的配体的测定中的用途，并且其可用作用于改变（阻断）T2R相关苦味的食品，饮料和药物中的添加剂。
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6.发明授权Use of specific T2R taste receptors to identify compounds that block bitter taste 有权使用特定的T2R味觉受体来鉴别抑制苦味的化合物公开(公告)号：US07338771B2
公开(公告)日：2008-03-04
申请号：US10191058
申请日：2002-07-10
申请人： Alexey Pronin , Judy Connor , Huixian Tang , Walter Keung , Guy Servant , Jon Elliot Adler , Shawn O'Connell , Paul Brust
发明人： Alexey Pronin , Judy Connor , Huixian Tang , Walter Keung , Guy Servant , Jon Elliot Adler , Shawn O'Connell , Paul Brust
IPC分类号： G01N33/566
CPC分类号： G01N33/566 , G01N2333/726 , G01N2500/02 , G01N2500/04 , G01N2500/10
摘要： Assays for identifying compounds that modulate, preferably inhibit bitter taste associated with the activation of hT2R4, hT2R44 and/or hT2R61 are provided. The compounds identified according to these assays should modulate, e.g., inhibit bitter taste associated with bitter tasting compounds including quinine, 6-nitrosaccharin, saccharin and/or denatonium. These compounds are useful additives for foods, beverages or medicinal preparations having a bitter taste.
摘要翻译： 提供了用于鉴定调节，优选抑制与激活hT2R4，hT2R44和/或hT2R61相关的苦味的化合物的分析。 根据这些测定法鉴定的化合物应调节，例如抑制与苦味化合物（包括奎宁，6-亚硝基糖精，糖精和/或丹参）相关的苦味。 这些化合物是具有苦味的食品，饮料或药物制剂的有用添加剂。
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7.发明申请IDENTIFICATION OF BITTER LIGANDS THAT SPECIFICALLY ACTIVATE HUMAN T2R RECEPTORS AND RELATED ASSAYS FOR IDENTIFYING HUMAN BITTER TASTE MODULATORS 有权识别特异性激活人类T2R受体的双键配体和用于鉴定人类叮咬调味剂的相关测定公开(公告)号：US20080038739A1
公开(公告)日：2008-02-14
申请号：US11766974
申请日：2007-06-22
申请人： Xiaodong LI , Hong Xu , Qing Li , Huixian Tang , Alexey Pronin
发明人： Xiaodong LI , Hong Xu , Qing Li , Huixian Tang , Alexey Pronin
CPC分类号： G01N33/566 , G01N33/5008 , G01N33/5023 , G01N2500/00 , G01N2500/10
摘要： The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds. Also, the invention relates to the discovery of specific hT2R9 alleles and their disparate activity in functional assays with the same biter ligands. The invention further relates to the use of these T2R receptors in assays for identifying ligands that modulate the activation of these taste receptors by specific bitter ligands and related compounds. These compounds may be used as additives and/or removed from foods, beverages, cosmetics and medicinals in order to modify (block) T2R-associated bitter taste. Also T2R ligands may be used as therapeutics to treat and modulate T2R associated gastrointestinal and metabolic functions as well as treat gastrointestinal and metabolic diseases such as eating disorders, food sensing, food absorption, obesity, diabetes, Crohn's disease, celiac disease, et al.
摘要翻译： 本发明涉及T2R味觉受体家族中的特定人味受体对特定苦味化合物的反应的发现。 此外，本发明还涉及特异性hT2R9等位基因的发现及其在具有相同配体配体的功能测定中的不同活性。 本发明还涉及这些T2R受体在用于鉴定通过特定的苦配体和相关化合物调节这些味觉受体的活化的配体的测定中的用途。 这些化合物可以用作添加剂和/或从食品，饮料，化妆品和药物中去除，以便改变（阻断）T2R相关的苦味。 也可以使用T2R配体作为治疗和调节T2R相关胃肠和代谢功能以及治疗胃肠道和代谢疾病如饮食失调，食物感觉，食物吸收，肥胖，糖尿病，克罗恩病，乳糜泻等的治疗剂。
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8.发明授权公开(公告)号：US08318447B2
公开(公告)日：2012-11-27
申请号：US13094974
申请日：2011-04-27
申请人： Xiaodong Li , Hong Xu , Qing Li , Huixian Tang
发明人： Xiaodong Li , Hong Xu , Qing Li , Huixian Tang
IPC分类号： G01N33/567 , C07K14/705
CPC分类号： C07K14/705 , G01N33/566 , G01N2333/726 , G01N2500/00 , G01N2500/10 , Y10S514/974
摘要： The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds, i.e., chlorogenic lactone compounds that contribute at least partially to the bitter taste of many coffee beverages. The present invention further relates to the use of these receptors in assays for identifying ligands that modulate the activation of these taste receptors by chlorogenic lactones and related compounds and which may be used as additives and/or removed from foods, beverages and medicinals in order to modify (block) T2R-associated bitter taste. A preferred embodiment is the use of the identified compounds as additives in coffee and coffee-flavored foods, beverages and medicinals.
摘要翻译： 本发明涉及T2R味觉受体家族中的特定人味受体对特定苦味化合物的反应的发现，即，至少部分地促成许多咖啡饮料的苦味的绿色内酯化合物。 本发明还涉及这些受体在测定中用于鉴定调节绿色内酯和相关化合物来调节这些味觉受体的活化并可以用作添加剂和/或从食品，饮料和药物中去除的配体的用途，以便 修改（阻断）T2R相关的苦味。 优选的实施方案是使用所鉴定的化合物作为咖啡和咖啡风味食品，饮料和药物中的添加剂。
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9.发明授权Use of specific T2R taste receptors to identify compounds that block bitter taste 有权使用特定的T2R味觉受体来鉴别抑制苦味的化合物公开(公告)号：US08071320B2
公开(公告)日：2011-12-06
申请号：US12854570
申请日：2010-08-11
申请人： Alexey Pronin , Judy Connor , Huixian Tang , Walter Keung , Guy Servant , Jon Elliot Adler , Shawn O'Connell , Paul Brust
发明人： Alexey Pronin , Judy Connor , Huixian Tang , Walter Keung , Guy Servant , Jon Elliot Adler , Shawn O'Connell , Paul Brust
IPC分类号： G01N33/566 , C07K14/705
CPC分类号： G01N33/566 , G01N2333/726 , G01N2500/02 , G01N2500/04 , G01N2500/10
摘要： Assays for identifying compounds that modulate, preferably inhibit bitter taste associated with the activation of hT2R4, hT2R44 and/or hT2R61 are provided. The compounds identified according to these assays should modulate, e.g., inhibit bitter taste associated with bitter tasting compounds including quinine, 6-nitrosaccharin, saccharin and/or denatonium. These compounds are useful additives for foods, beverages or medicinal preparations having a bitter taste.
摘要翻译： 提供了用于鉴定调节，优选抑制与激活hT2R4，hT2R44和/或hT2R61相关的苦味的化合物的分析。 根据这些测定法鉴定的化合物应调节，例如抑制与苦味化合物（包括奎宁，6-亚硝基糖精，糖精和/或丹参）相关的苦味。 这些化合物是具有苦味的食品，饮料或药物制剂的有用添加剂。
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10.发明授权Human T2R receptors for ranitidine, strychnine and denatonium and related assays for identifying human bitter taste modulators 有权用于雷尼替丁，士的宁和denatonium的人T2R受体和用于鉴定人类苦味调节剂的相关测定法公开(公告)号：US07915003B2
公开(公告)日：2011-03-29
申请号：US12166980
申请日：2008-07-02
申请人： Xiaodong Li , Hong Xu , Huixian Tang , Qing Li
发明人： Xiaodong Li , Hong Xu , Huixian Tang , Qing Li
IPC分类号： G01N33/566 , C07K14/705
CPC分类号： G01N33/74 , G01N33/566 , G01N2333/726 , G01N2500/02
摘要： The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter ligands, i.e., acetaminophen, ranitidine, strychnine and denatonium. The present invention further relates to the use of these receptors in assays for identifying ligands that modulate the activation of these taste receptors and which may be used as additives in foods, beverages and medicinals for modifying (blocking) T2R-associated bitter taste.
摘要翻译： 本发明涉及T2R味觉受体家族中的特定人味受体对特定苦味配体即对乙酰氨基酚，雷尼替丁，士的宁和丹那铵的反应的发现。 本发明还涉及这些受体在用于鉴定调节这些味觉受体的活化的配体的测定中的用途，并且其可用作用于改变（阻断）T2R相关苦味的食品，饮料和药物中的添加剂。
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