发明授权
US08324412B2 Method for preparing 4-[17β-methoxy-17α-methoxymethyl-3-oxoestra-4,9-dien-11β-yl]benzaldehyde (E)-oxime (asoprisnil)
有权
制备4- [17β-甲氧基-17α-甲氧基甲基-3-氧代雌-4,9-二烯-11β-基]苯甲醛（E） - 肟（asoprisnil）的方法，
![Method for preparing 4-[17β-methoxy-17α-methoxymethyl-3-oxoestra-4,9-dien-11β-yl]benzaldehyde (E)-oxime (asoprisnil)](/docs/US/2012-12-04/US08324412B2/abs.jpg.600x600.jpg)
- 专利标题： Method for preparing 4-[17β-methoxy-17α-methoxymethyl-3-oxoestra-4,9-dien-11β-yl]benzaldehyde (E)-oxime (asoprisnil)
- 专利标题（中）： 制备4- [17β-甲氧基-17α-甲氧基甲基-3-氧代雌-4,9-二烯-11β-基]苯甲醛（E） - 肟（asoprisnil）的方法，
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申请号： US12987850申请日： 2011-01-10
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公开(公告)号： US08324412B2公开(公告)日： 2012-12-04
- 发明人: Detlef Grawe , Sabine Gliesing , Hagen Gerecke , Peter Hoesel , Uwe Mueller , Thomas Michel , Robert Eilers , Uwe Knabe , Bernd Erhart , Michael Mosebach , David Voigtlaender , Ulf Tilstam , Jürgen Jacke , Klaus Bahl , Ulf Bohlmann , Dieter Wehmeier , Michael Sander
- 申请人： Detlef Grawe , Sabine Gliesing , Hagen Gerecke , Peter Hoesel , Uwe Mueller , Thomas Michel , Robert Eilers , Uwe Knabe , Bernd Erhart , Michael Mosebach , David Voigtlaender , Ulf Tilstam , Jürgen Jacke , Klaus Bahl , Ulf Bohlmann , Dieter Wehmeier , Michael Sander
- 申请人地址： DE Berlin
- 专利权人： Bayer Pharma AG
- 当前专利权人： Bayer Pharma AG
- 当前专利权人地址： DE Berlin
- 代理机构： Millen, White, Zelano & Branigan, P.C.
- 主分类号： C07J1/00
- IPC分类号： C07J1/00
![Method for preparing 4-[17β-methoxy-17α-methoxymethyl-3-oxoestra-4,9-dien-11β-yl]benzaldehyde (E)-oxime (asoprisnil)](/abs-image/US/2012/12/04/US08324412B2/abs.jpg.150x150.jpg)
摘要：
The present invention relates to a method for the reliable and reproducible preparation of 4-[17β-methoxy-17α-methoxymethyl-3-oxoestra-4,9-dien-11β-yl]benzaldehyde (E)-oxime (asoprisnil) on the pilot and manufacturing scale. Asoprisnil, which is prepared by this method, is distinguished by a very good physical stability and is therefore particularly suitable for the manufacture of solid pharmaceutical forms (tablets, coated tablets, etc.).
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