摘要:
The present invention relates to a method for the reliable and reproducible preparation of 4-[17β-methoxy-17α-methoxymethyl-3-oxoestra-4,9-dien-11β-yl]benzaldehyde (E)-oxime (asoprisnil) on the pilot and manufacturing scale. Asoprisnil, which is prepared by this method, is distinguished by a very good physical stability and is therefore particularly suitable for the manufacture of solid pharmaceutical forms (tablets, coated tablets, etc.).
摘要:
The present invention relates to a method for the reliable and reproducible preparation of 4-[17β-methoxy-17α-methoxymethyl-3-oxoestra-4,9-dien-11β-yl]benzaldehyde (E)-oxime (asoprisnil) on the pilot and manufacturing scale. Asoprisnil, which is prepared by this method, is distinguished by a very good physical stability and is therefore particularly suitable for the manufacture of solid pharmaceutical forms (tablets, coated tablets, etc.).
摘要:
The present invention refers to a composition, comprising hemoglobin or myoglobin, wherein in at least 40% of said hemoglobin or myoglobin the oxygen binding site is charged by a non-O2 ligand, and at least one further ingredient, a method for preparing said composition and the use of hemoglobin or myoglobin charged with a non-oxygen ligand for external treatment of wounds.
摘要:
This invention is directed to the crystalline potassium salt of a lipoxin A4 analog of Formula (I): processes for preparing the crystalline potassium salts, methods for using them to treat disease-states characterized by inflammation, and pharmaceutical compositions comprising such crystalline potassium salts.
摘要:
In a method and a kryomagnet for the pulsed magnetization of the kryomagnet which comprises discs stacked on top of one another, with each disc including concentric annular conductor elements arranged in axially spaced relationship and each conductor element having two contact points forming two arms between the contact points for their energization, a transport current impulse is applied to each conductor element which pulse is divided in each conductor element into first and second partial currents I1 and I2 to flow through the two arms from one of the contact points in an opposite sense to the other contact point, wherein one arm has a length of maximally 35% of the circumference of the conductor element, the transport current having a polarity such that the larger partial current flowing through the shorter arm while the transport current is increasing flows in all the conductor elements in the same direction.
摘要:
The present invention relates to a process for preparing 1-O-acyl-2-deoxy-2-fluoro-4-thio-β-D-arabinofuranoses having formula I and intermediates thereof: wherein R1 represents —C(O)—C1-C6-alkyl or —C(O)-aryl; and R2 represents C1-C6-alkyl, C1-C4-perfluoroalkyl or aryl.
摘要:
A method, non-transitory computer readable medium, and apparatus that determines a GPS location includes obtaining assisted GPS data of locations of a plurality of GPS satellites, current time, and initial location data of the receiver computing device. A GPS signal from one or more of the plurality of GPS satellites within a frequency range and time range is acquired based on the obtained assisted GPS data, current time, and initial location data of the receiver computing device. The one or more acquired GPS signals are integrated over a frame period of two or more seconds. A GPS location for the receiver computing device is determined based on the one or more integrated GPS signals.
摘要:
This invention is directed to the crystalline potassium salt of a lipoxin A4 analog of Formula (I): processes for preparing the crystalline potassium salts, methods for using them to treat disease-states characterized by inflammation, and pharmaceutical compositions comprising such crystalline potassium salts.
摘要:
The invention relates to a process for the preparation of amines by hydrogenation of nitro compounds, which comprises carrying out the hydrogenation in a vertical reactor whose length is greater than its diameter, having a downward-facing jet nozzle arranged in the upper region of the reactor through which the starting materials and the reaction mixture are fed in, and having an outlet at any desired point of the reactor, through which the reaction mixture is fed back to the jet nozzle in an external circuit by means of a conveying means, and having flow reversal in the lower region of the reactor.
摘要:
The present invention refers to a composition, comprising hemoglobin or myoglobin, wherein in at least 40% of said hemoglobin or myoglobin the oxygen binding site is charged by a non-O2 ligand, and at least one further ingredient, a method for preparing said composition and the use of hemoglobin or myoglobin charged with a non-oxygen ligand for external treatment of wounds.