发明授权
US08329420B2 Screening method for a substance that binds to an intracellular region of TLR4
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结合TLR4细胞内区域的物质的筛选方法
- 专利标题: Screening method for a substance that binds to an intracellular region of TLR4
- 专利标题(中): 结合TLR4细胞内区域的物质的筛选方法
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申请号: US12225721申请日: 2007-03-29
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公开(公告)号: US08329420B2公开(公告)日: 2012-12-11
- 发明人: Osamu Hazeki , Kaoru Hazeki , Masayuki Ii , Naoko Matsunaga
- 申请人: Osamu Hazeki , Kaoru Hazeki , Masayuki Ii , Naoko Matsunaga
- 申请人地址: JP Hiroshima JP Osaka
- 专利权人: Hiroshima University,Takeda Pharmaceutical Company Limited
- 当前专利权人: Hiroshima University,Takeda Pharmaceutical Company Limited
- 当前专利权人地址: JP Hiroshima JP Osaka
- 代理机构: Foley & Lardner LLP
- 优先权: JP2006-095936 20060330
- 国际申请: PCT/JP2007/056962 WO 20070329
- 国际公布: WO2007/114296 WO 20071011
- 主分类号: G01N33/567
- IPC分类号: G01N33/567 ; C12N1/21 ; C12N1/19 ; C12N5/10 ; C12N5/16 ; C12N5/18 ; C12N5/22 ; C07K14/705
摘要:
The present invention provides a method of screening for a drug for the prophylaxis or treatment of at least one disease selected from the group consisting of cardiac disease, autoimmune disease, inflammatory disease, central nervous system disease, infectious disease, sepsis, severe sepsis and septic shock, which includes selecting a substance that binds to an intracellular region of TLR4, and inhibits signal transduction from said molecule, and a kit for this method, which contains (1) a cell that expresses wild-type TLR4 and (2) a cell that expresses a mutant TLR4, and which can detect a signal from TLR4 with expression of a reporter gene as an index.
公开/授权文献
- US20090317833A1 Screening Method 公开/授权日:2009-12-24