发明授权
- 专利标题： Gradient structures interfacing microfluidics and nanofluidics
- 专利标题（中）： 梯度结构界面微流体和纳米流体
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申请号： US11536178申请日： 2006-09-28
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公开(公告)号： US08333934B2公开(公告)日： 2012-12-18
- 发明人: Han Cao , Jonas O. Tegenfeldt , Stephen Chou , Robert H. Austin
- 申请人： Han Cao , Jonas O. Tegenfeldt , Stephen Chou , Robert H. Austin
- 申请人地址： US NJ Princeton
- 专利权人： Princeton University
- 当前专利权人： Princeton University
- 当前专利权人地址： US NJ Princeton
- 代理机构： Riverside Law LLP
- 主分类号： G01N21/00
- IPC分类号： G01N21/00 ; G01N21/75 ; G01N33/00 ; B01L3/00
摘要：
The present invention relates to a device for interfacing nanofluidic and microfluidic components suitable for use in performing high throughput macromolecular analysis. Diffraction gradient lithography (DGL) is used to form a gradient interface between a microfluidic area and a nanofluidic area. The gradient interface area reduces the local entropic barrier to nanochannels formed in the nanofluidic area. In one embodiment, the gradient interface area is formed of lateral spatial gradient structures for narrowing the cross section of a value from the micron to the nanometer length scale. In another embodiment, the gradient interface area is formed of a vertical sloped gradient structure. Additionally, the gradient structure can provide both a lateral and vertical gradient.
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