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    Single step gas phase flame synthesis method to produce sub-10 nanometer sized rare earth doped nanoparticles
    1.
    发明授权
    Single step gas phase flame synthesis method to produce sub-10 nanometer sized rare earth doped nanoparticles 有权
    单步气相火焰合成法生产亚10纳米稀土掺杂纳米粒子

    公开(公告)号：US08017036B1

    公开(公告)日：2011-09-13

    申请号：US12049124

    申请日：2008-03-14

    申请人： Robert H. Austin ,  Shuang Fang Lim ,  Robert Riehn

    发明人： Robert H. Austin ,  Shuang Fang Lim ,  Robert Riehn

    IPC分类号： C09K11/08 ,  C09K11/56 ,  C09K11/61

    CPC分类号： C09K11/777 ,  B82Y40/00 ,  C09K11/7771

    摘要： Methods for forming rare earth element doped oxide, oxyhalide and oxysulfide activated nanoparticles by the following method steps: (a) providing a precursor solution of a water- or alcohol-soluble host metal salt or host metalloid compound and one or more water- or alcohol-soluble rare earth element salts in a polar solution; (b) forming an aerosol of the precursor solution and oxygen; (c) feeding the aerosol to a heated Laval tube (d) igniting the aerosol with a reactive gas flame at the apex of the Laval tube to pyrolyze the salts; and (e) expanding and cooling the pyrolysis gases emerging from the Laval tube so that rare earth element doped nanoparticles precipitate therefrom; wherein one or more of the aerosol particle size, flow rate through the Laval tube and pyrolysis temperature are selected to provide a predetermined particle size and degree of crystallinity without particle aggregation. Rare earth element doped oxide, oxyhalide and oxysulfide activated mono-disperse nanoparticles are also disclosed.

    摘要翻译： 通过以下方法步骤形成掺杂稀土元素的氧化物，卤氧化物和氧硫化物活化的纳米颗粒的方法：（a）提供水或醇可溶性主体金属盐或主体准金属化合物和一种或多种水或醇的前体溶液 - 极性溶液中的可溶性稀土元素盐; （b）形成前体溶液和氧气的气溶胶; （c）将气溶胶送入加热的拉瓦尔管（d），在拉瓦尔管的顶点用反应性气体火焰点燃气溶胶以使盐发生热解; 和（e）膨胀和冷却从拉瓦尔管出来的热解气体，使得稀土元素掺杂的纳米颗粒从其中沉淀出来; 其中选择气溶胶颗粒尺寸，通过拉瓦尔管的流速和热解温度中的一种或多种以提供预定的粒度和结晶度而没有颗粒聚集。 还公开了稀土元素掺杂的氧化物，卤氧化物和氧硫化物活化的单分散纳米颗粒。

    Electrode-less dielectrophorises for polarizable particles
    2.
    发明授权
    Electrode-less dielectrophorises for polarizable particles 失效
    用于可极化颗粒的无电极介电性能

    公开(公告)号：US06824664B1

    公开(公告)日：2004-11-30

    申请号：US09707892

    申请日：2000-11-06

    申请人： Robert H. Austin ,  Jonas O. Tegenfeldt ,  Edward C. Cox ,  Chia Fu Chou ,  Olgica Bakajin

    发明人： Robert H. Austin ,  Jonas O. Tegenfeldt ,  Edward C. Cox ,  Chia Fu Chou ,  Olgica Bakajin

    IPC分类号： C02F140

    CPC分类号： B01L3/502761 ,  B01L7/52 ,  B01L2200/0668 ,  B01L2300/0819 ,  B01L2300/0822 ,  B01L2400/0421 ,  B01L2400/0424 ,  B03C5/024 ,  B03C5/026

    摘要： The present invention further provides a device for the integrated micromanipulation, amplification, and analysis of polarized particles such as DNA comprises a microchip which contains constrictions of insulating material for dielectrophoresis powered by an alternating current or direct current signal generator, and attached to a hot source that can be heated to specific temperatures. Nucleic acids can be heated and cooled to allow for denaturation, and the annealing of complementary primers and enzymatic reactions, as in a thermocycling reaction. After such a reaction has been completed at the constriction, the dielectrophoretic field can be switched to a direct field to release the product and direct it through a matrix for fractionation. The device includes data analysis equipment for the control of these operations, and imaging equipment for the analysis of the products. The invention permits the efficient handling of minute samples in large numbers, since reactions occur while sample material is trapped between constrictions. Because the positioning, reactions, and release into a fractioning matrix all occur at the constriction which serves as a focusing locus, the need to transfer samples into different tubes is eliminated, thus increasing the efficiency and decreasing the possibility of damage to the samples.

    摘要翻译： 本发明还提供了用于对诸如DNA的极化粒子进行集成显微操作，放大和分析的装置，包括微芯片，其包含用于由交流电或直流信号发生器供电的介电电泳的绝缘材料的收缩部分，并连接到热源 可以加热到特定温度。 核酸可被加热和冷却以允许变性，以及互补引物的退火和酶反应，如在热循环反应中。 在收缩处完成这样的反应之后，介电电泳场可以切换到直接场以释放产物并将其引导通过基质进行分馏。 该设备包括用于控制这些操作的数据分析设备和用于分析产品的成像设备。 本发明允许有效地处理微量样品，因为在样品材料被捕获在收缩之间时发生反应。 因为定位，反应和释放到分级矩阵中都会发生在用作聚焦轨迹的收缩处，消除了将样品转移到不同管中的需要，从而提高了效率并降低了样品损伤的可能性。

    Reversibly sealable microstructure sorting devices
    6.
    发明授权
    Reversibly sealable microstructure sorting devices 有权
    可反复密封的微结构分选装置

    公开(公告)号：US06632652B1

    公开(公告)日：2003-10-14

    申请号：US09153054

    申请日：1998-09-15

    申请人： Robert H. Austin ,  Robert H. Carlson

    发明人： Robert H. Austin ,  Robert H. Carlson

    IPC分类号： C12M100

    CPC分类号： B01J19/0093 ,  B01J2219/00783 ,  B01J2219/0081 ,  B01J2219/00833 ,  B01L3/5027 ,  C12M47/04 ,  G01N30/90 ,  G01N2015/149

    摘要： Methods and apparatus for sorting microstructures, such as macromolecules, viruses, cells, and minute particles, in a fluid using microlithographic sorting array that is reversibly sealed by a cover. A silicone elastomer cover is used in one embodiment. In another, silicon microstructures are used to case elastomeric replicas of obstacle arrays, the tops of which reversibly seal against a flat surface. The reversible seal allows access to fractionated microstructures within the structure for further analysis.

    摘要翻译： 使用由盖可逆地密封的微光刻分类阵列在流体中分选微结构例如大分子，病毒，细胞和微小颗粒的方法和装置。 在一个实施例中使用有机硅弹性体覆盖物。 另一方面，硅微结构被用来表示障碍物阵列的弹性体副本，其顶部可逆地密封在平坦表面上。 可逆密封允许进入结构内的分级微结构进行进一步分析