A method for decontaminating bioaerosol with high concentrations of bacterial, viral, spore and other airborne microorganisms or biologic contaminants, in flight at high flow rates. A plasma screen created across the flow of air contaminated with airborne biologic agents renders contaminants non-culturable within millisecond. The technology may cooperate with heating, ventilation, and air conditioning (HVAC) systems. It may be particularly beneficial in preventing bioterrorism and the spread of toxic or infectious agents, containing airborne pandemic threats such as avian flu, sterilizing spaces such as hospitals, pharmaceutical plants and manufacturing facilities, treating exhaust ventilation streams, minimizing biological environmental pollutants in industrial settings, improving general air quality, and preventing sick building syndrome.