发明授权
US08338362B2 Methods for controlling SR protein phosphorylation, and antiviral agents whose active ingredients comprise agents that control SR protein activity
有权
用于控制SR蛋白磷酸化的方法，以及其活性成分包含控制SR蛋白活性的试剂的抗病毒剂
- 专利标题： Methods for controlling SR protein phosphorylation, and antiviral agents whose active ingredients comprise agents that control SR protein activity
- 专利标题（中）： 用于控制SR蛋白磷酸化的方法，以及其活性成分包含控制SR蛋白活性的试剂的抗病毒剂
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申请号： US12494102申请日： 2009-06-29
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公开(公告)号： US08338362B2公开(公告)日： 2012-12-25
- 发明人: Masatoshi Hagiwara , Takeshi Fukuhara , Masaaki Suzuki , Takamitsu Hosoya
- 申请人： Masatoshi Hagiwara , Takeshi Fukuhara , Masaaki Suzuki , Takamitsu Hosoya
- 申请人地址： JP Chiba
- 专利权人： Masatoshi Hagiwara
- 当前专利权人： Masatoshi Hagiwara
- 当前专利权人地址： JP Chiba
- 代理机构： Klarquist Sparkman, LLP
- 优先权： JP2003-435085 20031226
- 主分类号： A01N61/00
- IPC分类号： A01N61/00 ; A61K31/00 ; A61K49/00 ; C12N15/09 ; C12N9/12
摘要：
The present invention provides: (1) antiviral agents that act by reducing or inhibiting the activity of SR proteins, more specifically, (i) antiviral agents that act by enhancing dephosphorylation of SR proteins, and (ii) antiviral agents that act by inhibiting proteins that phosphorylate SR proteins; (2) antiviral agents that act by inhibiting the expression of SR proteins, and (3) antiviral agents that act by activating proteins that antagonize SR proteins. The present invention also provides compounds that inhibit SRPKs, which phosphorylate SR proteins. Such compounds inhibit the activity of SR proteins and have antiviral activities. Various new viruses including SARS have emerged, and thus the present invention provides long-lasting broad-spectrum antiviral agents applicable to new viruses.
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