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公开(公告)号：US20130102644A1
公开(公告)日：2013-04-25
申请号：US13805151
申请日：2011-06-27
IPC分类号： A61K31/428
CPC分类号： A61K31/428 , C07D277/64 , C07K14/4707 , C07K14/4708 , C12N9/12
摘要： An object of the present invention is to provide a prophylactic or ameliorating agent for a genetic disease that is caused by a mutation in an exon of a gene and is capable of forming a functional truncated protein by skipping of the exon comprising the mutation. The prophylactic or ameliorating agent used in the present invention is a prophylactic or ameliorating agent for a genetic disease that is caused by a mutation in an exon of a gene and is capable of forming a functional truncated protein by skipping of the exon comprising the mutation, wherein the prophylactic or ameliorating agent contains a compound having a molecular weight of 1500 or lower.
摘要翻译： 本发明的目的是提供由基因外显子突变引起的遗传疾病的预防或改善剂，并且能够通过跳过包含突变的外显子形成功能性截短的蛋白质。 用于本发明的预防或改善剂是由基因外显子突变引起的遗传疾病的预防或改善剂，能够通过跳过包含突变的外显子形成功能性截短蛋白， 其中所述预防或改善剂含有分子量为1500以下的化合物。
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2.发明授权Method for controlling SR protein phosphorylation, and antiviral agents whose active ingredients comprise agents that control SR protein activity 有权用于控制SR蛋白磷酸化的方法，以及其活性成分包含控制SR蛋白活性的试剂的抗病毒剂公开(公告)号：US07569536B2
公开(公告)日：2009-08-04
申请号：US10584482
申请日：2004-12-24
CPC分类号： A61K31/444 , A61K31/4409 , A61K31/4439 , A61K31/4453 , A61K31/4545 , A61K31/455 , A61K31/5377 , A61K31/55 , C07D211/14 , C07D213/81 , C07D213/82 , C07D401/12 , C12N15/1137 , Y02A50/385 , Y02A50/389 , Y02A50/463 , Y02A50/465 , Y02A50/467
摘要： The present invention provides: (1) antiviral agents that act by reducing or inhibiting the activity of SR proteins, more specifically, (i) antiviral agents that act by enhancing dephosphorylation of SR proteins, and (ii) antiviral agents that act by inhibiting proteins that phosphorylate SR proteins; (2) antiviral agents that act by inhibiting the expression of SR proteins, and (3) antiviral agents that act by activating proteins that antagonize SR proteins. The present invention also provides compounds that inhibit SRPKs, which phosphorylate SR proteins. Such compounds inhibit the activity of SR proteins and have antiviral activities. Various new viruses including SARS have emerged, and thus the present invention provides long-lasting broad-spectrum antiviral agents applicable to new viruses.
摘要翻译： 本发明提供：（1）通过降低或抑制SR蛋白的活性而起作用的抗病毒剂，更具体地，（i）通过增强SR蛋白的去磷酸化作用的抗病毒剂，和（ii）通过抑制蛋白质起作用的抗病毒剂 磷酸化SR蛋白; （2）通过抑制SR蛋白的表达起作用的抗病毒剂，和（3）通过激活拮抗SR蛋白的蛋白质起作用的抗病毒剂。 本发明还提供抑制磷酸化SR蛋白的SRPK的化合物。 这些化合物抑制SR蛋白的活性并具有抗病毒活性。 出现了包括SARS在内的各种新病毒，因此本发明提供了适用于新病毒的长效广谱抗病毒剂。
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3.发明授权Methods for controlling SR protein phosphorylation, and antiviral agents whose active ingredients comprise agents that control SR protein activity 有权用于控制SR蛋白磷酸化的方法，以及其活性成分包含控制SR蛋白活性的试剂的抗病毒剂公开(公告)号：US08816089B2
公开(公告)日：2014-08-26
申请号：US13680538
申请日：2012-11-19
申请人： Masatoshi Hagiwara
IPC分类号： C07D211/68 , C07D211/80 , C07D213/02 , A01N43/40 , A61K31/445
CPC分类号： A61K31/444 , A61K31/4409 , A61K31/4439 , A61K31/4453 , A61K31/4545 , A61K31/455 , A61K31/5377 , A61K31/55 , C07D211/14 , C07D213/81 , C07D213/82 , C07D401/12 , C12N15/1137 , Y02A50/385 , Y02A50/389 , Y02A50/463 , Y02A50/465 , Y02A50/467
摘要： The present invention provides: (1) antiviral agents that act by reducing or inhibiting the activity of SR proteins, more specifically, (i) antiviral agents that act by enhancing dephosphorylation of SR proteins, and (ii) antiviral agents that act by inhibiting proteins that phosphorylate SR proteins; (2) antiviral agents that act by inhibiting the expression of SR proteins, and (3) antiviral agents that act by activating proteins that antagonize SR proteins. The present invention also provides compounds that inhibit SRPKs, which phosphorylate SR proteins. Such compounds inhibit the activity of SR proteins and have antiviral activities. Various new viruses including SARS have emerged, and thus the present invention provides long-lasting broad-spectrum antiviral agents applicable to new viruses.
摘要翻译： 本发明提供：（1）通过降低或抑制SR蛋白的活性而起作用的抗病毒剂，更具体地，（i）通过增强SR蛋白的去磷酸化作用的抗病毒剂，和（ii）通过抑制蛋白质起作用的抗病毒剂 磷酸化SR蛋白; （2）通过抑制SR蛋白的表达起作用的抗病毒剂，和（3）通过激活拮抗SR蛋白的蛋白质起作用的抗病毒剂。 本发明还提供抑制磷酸化SR蛋白的SRPK的化合物。 这些化合物抑制SR蛋白的活性并具有抗病毒活性。 出现了包括SARS在内的各种新病毒，因此本发明提供了适用于新病毒的长效广谱抗病毒剂。
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4.发明授权Methods for controlling SR protein phosphorylation, and antiviral agents whose active ingredients comprise agents that control SR protein activity 有权用于控制SR蛋白磷酸化的方法，以及其活性成分包含控制SR蛋白活性的试剂的抗病毒剂公开(公告)号：US08338362B2
公开(公告)日：2012-12-25
申请号：US12494102
申请日：2009-06-29
CPC分类号： A61K31/444 , A61K31/4409 , A61K31/4439 , A61K31/4453 , A61K31/4545 , A61K31/455 , A61K31/5377 , A61K31/55 , C07D211/14 , C07D213/81 , C07D213/82 , C07D401/12 , C12N15/1137 , Y02A50/385 , Y02A50/389 , Y02A50/463 , Y02A50/465 , Y02A50/467
摘要： The present invention provides: (1) antiviral agents that act by reducing or inhibiting the activity of SR proteins, more specifically, (i) antiviral agents that act by enhancing dephosphorylation of SR proteins, and (ii) antiviral agents that act by inhibiting proteins that phosphorylate SR proteins; (2) antiviral agents that act by inhibiting the expression of SR proteins, and (3) antiviral agents that act by activating proteins that antagonize SR proteins. The present invention also provides compounds that inhibit SRPKs, which phosphorylate SR proteins. Such compounds inhibit the activity of SR proteins and have antiviral activities. Various new viruses including SARS have emerged, and thus the present invention provides long-lasting broad-spectrum antiviral agents applicable to new viruses.
摘要翻译： 本发明提供：（1）通过降低或抑制SR蛋白的活性而起作用的抗病毒剂，更具体地，（i）通过增强SR蛋白的去磷酸化作用的抗病毒剂，和（ii）通过抑制蛋白质起作用的抗病毒剂 磷酸化SR蛋白; （2）通过抑制SR蛋白的表达起作用的抗病毒剂，和（3）通过激活拮抗SR蛋白的蛋白质起作用的抗病毒剂。 本发明还提供抑制磷酸化SR蛋白的SRPK的化合物。 这些化合物抑制SR蛋白的活性并具有抗病毒活性。 出现了包括SARS在内的各种新病毒，因此本发明提供了适用于新病毒的长效广谱抗病毒剂。
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公开(公告)号：US09241929B2
公开(公告)日：2016-01-26
申请号：US13805151
申请日：2011-06-27
IPC分类号： A61K31/425 , A61K31/428 , C07K14/47 , C07D277/64 , C12N9/12
CPC分类号： A61K31/428 , C07D277/64 , C07K14/4707 , C07K14/4708 , C12N9/12
摘要： An object of the present invention is to provide a prophylactic or ameliorating agent for a genetic disease that is caused by a mutation in an exon of a gene and is capable of forming a functional truncated protein by skipping of the exon comprising the mutation. The prophylactic or ameliorating agent used in the present invention is a prophylactic or ameliorating agent for a genetic disease that is caused by a mutation in an exon of a gene and is capable of forming a functional truncated protein by skipping of the exon comprising the mutation, wherein the prophylactic or ameliorating agent contains a compound having a molecular weight of 1500 or lower.
摘要翻译： 本发明的目的是提供由基因外显子突变引起的遗传疾病的预防或改善剂，并且能够通过跳过包含突变的外显子形成功能性截短的蛋白质。 用于本发明的预防或改善剂是由基因外显子突变引起的遗传疾病的预防或改善剂，能够通过跳过包含突变的外显子形成功能性截短蛋白， 其中所述预防或改善剂含有分子量为1500以下的化合物。
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6.发明申请METHODS FOR CONTROLLING SR PROTEIN PHOSPHORYLATION, AND ANTIVIRAL AGENTS WHOSE ACTIVE INGREDIENTS COMPRISE AGENTS THAT CONTROL SR PROTEIN ACTIVITY 有权用于控制SR蛋白磷酸化的方法以及活性成分包含控制SR蛋白活性的试剂的抗病毒剂公开(公告)号：US20130079369A1
公开(公告)日：2013-03-28
申请号：US13680538
申请日：2012-11-19
IPC分类号： A61K31/444
CPC分类号： A61K31/444 , A61K31/4409 , A61K31/4439 , A61K31/4453 , A61K31/4545 , A61K31/455 , A61K31/5377 , A61K31/55 , C07D211/14 , C07D213/81 , C07D213/82 , C07D401/12 , C12N15/1137 , Y02A50/385 , Y02A50/389 , Y02A50/463 , Y02A50/465 , Y02A50/467
摘要： The present invention provides: (1) antiviral agents that act by reducing or inhibiting the activity of SR proteins, more specifically, (i) antiviral agents that act by enhancing dephosphorylation of SR proteins, and (ii) antiviral agents that act by inhibiting proteins that phosphorylate SR proteins; (2) antiviral agents that act by inhibiting the expression of SR proteins, and (3) antiviral agents that act by activating proteins that antagonize SR proteins. The present invention also provides compounds that inhibit SRPKs, which phosphorylate SR proteins. Such compounds inhibit the activity of SR proteins and have antiviral activities. Various new viruses including SARS have emerged, and thus the present invention provides long-lasting broad-spectrum antiviral agents applicable to new viruses.
摘要翻译： 本发明提供：（1）通过降低或抑制SR蛋白的活性而起作用的抗病毒剂，更具体地，（i）通过增强SR蛋白的去磷酸化起作用的抗病毒剂，和（ii）通过抑制蛋白质起作用的抗病毒剂 磷酸化SR蛋白; （2）通过抑制SR蛋白的表达起作用的抗病毒剂，和（3）通过激活拮抗SR蛋白的蛋白质起作用的抗病毒剂。 本发明还提供抑制磷酸化SR蛋白的SRPK的化合物。 这些化合物抑制SR蛋白的活性并具有抗病毒活性。 出现了包括SARS在内的各种新病毒，因此本发明提供了适用于新病毒的长效广谱抗病毒剂。
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7.发明申请METHODS FOR CONTROLLING SR PROTEIN PHOSPHORYLATION, AND ANTIVIRAL AGENTS WHOSE ACTIVE INGREDIENTS COMPRISE AGENTS THAT CONTROL SR PROTEIN ACTIVITY 有权用于控制SR蛋白磷酸化的方法以及活性成分包含控制SR蛋白活性的试剂的抗病毒剂公开(公告)号：US20100016359A1
公开(公告)日：2010-01-21
申请号：US12494102
申请日：2009-06-29
IPC分类号： A61K31/4545 , A61P31/12
CPC分类号： A61K31/444 , A61K31/4409 , A61K31/4439 , A61K31/4453 , A61K31/4545 , A61K31/455 , A61K31/5377 , A61K31/55 , C07D211/14 , C07D213/81 , C07D213/82 , C07D401/12 , C12N15/1137 , Y02A50/385 , Y02A50/389 , Y02A50/463 , Y02A50/465 , Y02A50/467
摘要： The present invention provides: (1) antiviral agents that act by reducing or inhibiting the activity of SR proteins, more specifically, (i) antiviral agents that act by enhancing dephosphorylation of SR proteins, and (ii) antiviral agents that act by inhibiting proteins that phosphorylate SR proteins; (2) antiviral agents that act by inhibiting the expression of SR proteins, and (3) antiviral agents that act by activating proteins that antagonize SR proteins. The present invention also provides compounds that inhibit SRPKs, which phosphorylate SR proteins. Such compounds inhibit the activity of SR proteins and have antiviral activities. Various new viruses including SARS have emerged, and thus the present invention provides long-lasting broad-spectrum antiviral agents applicable to new viruses.
摘要翻译： 本发明提供：（1）通过降低或抑制SR蛋白的活性而起作用的抗病毒剂，更具体地，（i）通过增强SR蛋白的去磷酸化作用的抗病毒剂，和（ii）通过抑制蛋白质起作用的抗病毒剂 磷酸化SR蛋白; （2）通过抑制SR蛋白的表达起作用的抗病毒剂，和（3）通过激活拮抗SR蛋白的蛋白质起作用的抗病毒剂。 本发明还提供抑制磷酸化SR蛋白的SRPK的化合物。 这些化合物抑制SR蛋白的活性并具有抗病毒活性。 出现了包括SARS在内的各种新病毒，因此本发明提供了适用于新病毒的长效广谱抗病毒剂。
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