发明授权
- 专利标题: Polynucleotides encoding antagonist antibodies against GDF-8
- 专利标题(中): 编码针对GDF-8的拮抗剂抗体的多核苷酸
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申请号: US13038954申请日: 2011-03-02
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公开(公告)号: US08372625B2公开(公告)日: 2013-02-12
- 发明人: Frank S. Walsh , Margaret M. Zaleska , David S. Howland , Lioudmila Tchistiakova , Riyez Karim , Pamela Kelley , Xiang-Yang Tan , Seung Poon Kwak , Menelas N. Pangalos
- 申请人: Frank S. Walsh , Margaret M. Zaleska , David S. Howland , Lioudmila Tchistiakova , Riyez Karim , Xiang-Yang Tan , Seung Poon Kwak , Menelas N. Pangalos , William Kelley
- 申请人地址: US NJ Madison
- 专利权人: Wyeth LLC
- 当前专利权人: Wyeth LLC
- 当前专利权人地址: US NJ Madison
- 代理机构: DLA Piper LLP (US)
- 主分类号: C07K16/00
- IPC分类号: C07K16/00 ; C12N5/10 ; C12N1/19 ; C12N15/63 ; C12N1/21 ; C07H21/04 ; C12P21/06
摘要:
The disclosure provides novel molecules related to growth and differentiation factor-8 (GDF-8), in particular mouse and humanized antibodies, and antibody fragments, including those that inhibit GDF-8 activity and signaling in vitro and/or in vivo. The disclosure also provides methods for diagnosing, treating, ameliorating, preventing, prognosing, or monitoring degenerative orders of muscle, bone, and insulin metabolism, etc., in particular amyotrophic lateral sclerosis (ALS). In addition, the disclosure provides pharmaceutical compositions for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.