Invention Grant
US08377902B2 RNAi compound targeted to thrombospondin-1 and applications thereof
有权
靶向血小板反应蛋白-1的RNAi化合物及其应用
- Patent Title: RNAi compound targeted to thrombospondin-1 and applications thereof
- Patent Title (中): 靶向血小板反应蛋白-1的RNAi化合物及其应用
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Application No.: US12985684Application Date: 2011-01-06
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Publication No.: US08377902B2Publication Date: 2013-02-19
- Inventor: Ming-Derg Lai , Shih-Shien Huang , Meng-Chi Yen , Chi-Chen Lin , Tzu-Yang Weng
- Applicant: Ming-Derg Lai , Shih-Shien Huang , Meng-Chi Yen , Chi-Chen Lin , Tzu-Yang Weng
- Applicant Address: TW
- Assignee: National Cheng Kung University
- Current Assignee: National Cheng Kung University
- Current Assignee Address: TW
- Agency: Bacon & Thomas, PLLC
- Priority: TW99100244A 20100107
- Main IPC: A61K31/70
- IPC: A61K31/70 ; C07H21/02 ; C07H21/04 ; C12Q1/68
Abstract:
The present invention relates to an RNAi compound and an expression plasmid for inhibiting expression of Thrombospondin-1, which comprises a target sequence selected from Thrombospondin-1 gene. The present invention also related to a pharmaceutical composition comprising the RNAi compound and applications thereof. The RNAi compound can reduce the expression of Thrombospondin-1 to activate immune responses. In addition, the present invention also disclosed that an RNAi compound targeted to Thrombospondin-1 gene can delay tumor progression.
Public/Granted literature
- US20110166199A1 RNAi COMPOUND TARGETED TO THROMBOSPONDIN-1 AND APPLICATIONS THEREOF Public/Granted day:2011-07-07
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