发明授权
- 专利标题： Tissue specific gene therapy treatment
- 专利标题（中）： 组织特异性基因治疗
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申请号： US12447558申请日： 2007-10-30
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公开(公告)号： US08383601B2公开(公告)日： 2013-02-26
- 发明人: Walter J. Koch , Patrick Most , Sven T. Pleger , Joseph E. Rabinowitz
- 申请人： Walter J. Koch , Patrick Most , Sven T. Pleger , Joseph E. Rabinowitz
- 申请人地址： US PA Philadelphia
- 专利权人： Thomas Jefferson University
- 当前专利权人： Thomas Jefferson University
- 当前专利权人地址： US PA Philadelphia
- 代理机构： Nixon Peabody LLP
- 代理商 David S. Resnick; Tari W. Mills
- 国际申请： PCT/US2007/022861 WO 20071030
- 国际公布： WO2008/054713 WO 20080508
- 主分类号： A61K48/00
- IPC分类号： A61K48/00 ; C12N15/11 ; C12N5/00
摘要：
The invention provides nucleic acid segments, compositions and methods for the treatment of heart failure, vascular dysfunction, endothelial dysfunction, diabetes, [Ca2+]i regulation and NO synthase dysfunction. Adeno-associated and adenovirus are used as gene delivery vectors for the nucleic acid segments to product long term over-expression of S100A1, a small calcium sensing protein associated with the disclosed ailments and dysfunctions.
公开/授权文献
- US20100190840A1 TISSUE SPECIFIC GENE THERAPY TREATMENT 公开/授权日：2010-07-29
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