发明授权
US08394934B2 Method and process for synthesis of 2',3'-didehydro-2',3'-dideoxynucleosides
失效
合成2'，3'-二脱氢-2'，3'-二脱氧核苷的方法和方法
- 专利标题： Method and process for synthesis of 2',3'-didehydro-2',3'-dideoxynucleosides
- 专利标题（中）： 合成2'，3'-二脱氢-2'，3'-二脱氧核苷的方法和方法
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申请号： US12933619申请日： 2009-03-20
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公开(公告)号： US08394934B2公开(公告)日： 2013-03-12
- 发明人: Zhen Huang , Jia Sheng
- 申请人： Zhen Huang , Jia Sheng
- 代理机构： Arnall Golden Gregory LLP
- 代理商 R. Stevan Coursey, Esq.
- 国际申请： PCT/US2009/037823 WO 20090320
- 国际公布： WO2009/117668 WO 20090924
- 主分类号： C07H1/00
- IPC分类号： C07H1/00 ; C07H19/00 ; C07H19/22 ; C07H19/048 ; C07D307/02
摘要：
A method is disclosed for synthesizing 2′,3′-didehydro-2′,3′-dideoxynucleosides (d4Ns) from a nucleophile-mediated elimination, such as a telluride-mediated elimination reaction. After substitution of 2,2′-anhydronucleosides with a nucleophile, such as a telluride monoanion, a telluride intermediate is formed, and its elimination leads to formation of the olefin products (d4Ns). This disclosure describes this telluride-assisted (or nucleophile-assisted) reaction and how to facilitate the substitution and elimination in order to form d4Ns.
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