公开(公告)号：US08394934B2

公开(公告)日：2013-03-12

申请号：US12933619

申请日：2009-03-20

申请人： Zhen Huang ,  Jia Sheng

发明人： Zhen Huang ,  Jia Sheng

IPC分类号： C07H1/00 ,  C07H19/00 ,  C07H19/22 ,  C07H19/048 ,  C07D307/02

CPC分类号： C07H19/06 ,  C07H19/16

摘要： A method is disclosed for synthesizing 2′,3′-didehydro-2′,3′-dideoxynucleosides (d4Ns) from a nucleophile-mediated elimination, such as a telluride-mediated elimination reaction. After substitution of 2,2′-anhydronucleosides with a nucleophile, such as a telluride monoanion, a telluride intermediate is formed, and its elimination leads to formation of the olefin products (d4Ns). This disclosure describes this telluride-assisted (or nucleophile-assisted) reaction and how to facilitate the substitution and elimination in order to form d4Ns.

摘要翻译： 公开了从亲核试剂介导的消除如碲化物介导的消除反应合成2'，3'-二脱氢-2'，3'-二脱氧核苷（d4Ns）的方法。 用亲核试剂（如碲化物单阴离子）代替2,2'-脱水核苷后，形成碲化物中间体，其消除导致烯烃产物（d4Ns）的形成。 本公开描述了这种碲化物辅助（或亲核试剂辅助）反应以及如何促进取代和消除以形成d4N。

公开(公告)号：US20110105743A1

公开(公告)日：2011-05-05

申请号：US12933619

申请日：2009-03-20

申请人： Zhen Huang ,  Jia Sheng

发明人： Zhen Huang ,  Jia Sheng

IPC分类号： C07H1/00 ,  C07D307/02

CPC分类号： C07H19/06 ,  C07H19/16

摘要： A method is disclosed for synthesizing 2′,3′-didehydro-2′,3′-dideoxynucleosides (d4Ns) from a nucleophile-mediated elimination, such as a telluride-mediated elimination reaction. After substitution of 2,2′-anhydronucleosides with a nucleophile, such as a telluride monoanion, a telluride intermediate is formed, and its elimination leads to formation of the olefin products (d4Ns). This disclosure describes this telluride-assisted (or nucleophile-assisted) reaction and how to facilitate the substitution and elimination in order to form d4Ns.

摘要翻译： 公开了从亲核试剂介导的消除如碲化物介导的消除反应合成2'，3'-二脱氢-2'，3'-二脱氧核苷（d4Ns）的方法。 用亲核试剂（如碲化物单阴离子）代替2,2'-脱水核苷后，形成碲化物中间体，其消除导致烯烃产物（d4Ns）的形成。 本公开描述了这种碲化物辅助（或亲核试剂辅助）反应以及如何促进取代和消除以形成d4N。

公开(公告)号：US10851003B2

公开(公告)日：2020-12-01

申请号：US13811149

申请日：2011-07-21

申请人： Matthew Silver ,  Justin Buck ,  Patrick Kiely ,  Juan J. Guzman ,  Zhen Huang

发明人： Matthew Silver ,  Justin Buck ,  Patrick Kiely ,  Juan J. Guzman ,  Zhen Huang

IPC分类号： C02F3/02 ,  A01K63/04 ,  C02F3/00 ,  C02F3/30

摘要： In one aspect, the present invention provides reactor designs, component designs, and operating schemes for removing nitrates and chemical oxygen demand from any suitable wastewater stream. In another aspect, the invention also provides reactor designs, component designs, and operating schemes designed to modify and improve pH and water quality in wastewater streams.

公开(公告)号：US09200286B2

公开(公告)日：2015-12-01

申请号：US13810572

申请日：2011-07-15

申请人： Li Niu ,  Zhen Huang ,  Jae Seon Park

发明人： Li Niu ,  Zhen Huang ,  Jae Seon Park

IPC分类号： C07H21/04 ,  C12N15/115 ,  C12N15/11 ,  C12N15/113

CPC分类号： C12N15/115 ,  C12N15/111 ,  C12N15/1138 ,  C12N2310/16 ,  C12N2310/322 ,  C12N2310/3533 ,  C12N2320/13

摘要： Inhibitors of AMPA-type glutamate ion channels are useful as biochemical probes for structure-function studies and as drug candidates for a number of neurological disorders and diseases. Disclosed herein is the identification of an RNA inhibitor or aptamer by an in vitro evolution approach and characterization of its mechanism of inhibition on the sites of interaction by equilibrium binding and on the receptor channel-opening rate by a laser-pulse photolysis technique. The aptamer of the invention is a noncompetitive inhibitor of AMPA-type glutamate ion channels, one that selectively inhibits the GluA2Qflip AMPA receptor subunit without any effect on other AMPA receptor subunits or on kainate or NMDA receptors. Furthermore, the aptamer preferentially inhibits the closed-channel state of GluA2Qflip with a KI=1.5 μM or by ˜15-fold over the open-channel state. The potency and selectivity of this aptamer rival those of small molecule inhibitors. Together, these properties make the aptamers of the present invention promising water-soluble, highly potent, GluA2 subunit-selective drugs.

摘要翻译： AMPA型谷氨酸离子通道的抑制剂可用作结构功能研究的生物化学探针和许多神经障碍和疾病的候选药物。 本文公开了通过体外进化方法鉴定RNA抑制剂或适体，并通过激光脉冲光解技术通过平衡结合和受体通道开放速率表征其抑制作用位点的机制。 本发明的适体是AMPA型谷氨酸离子通道的非竞争性抑制剂，其选择性地抑制GluA2Qflip AMPA受体亚基而对其它AMPA受体亚基或红藻氨酸或NMDA受体没有任何作用。 此外，适体优先抑制GluA2Qflip的闭通道状态，KI =1.5μM或比开放通道状态约〜15倍。 该适配体的效力和选择性与小分子抑制剂的效力和选择性相当。 这些性质一起使得本发明的适体具有潜在的水溶性，高效的GluA2亚基选择性药物。

公开(公告)号：US20130183765A1

公开(公告)日：2013-07-18

申请号：US13823028

申请日：2011-09-13

申请人： Zhen Huang

发明人： Zhen Huang

IPC分类号： G01N21/63

CPC分类号： G01N21/631 ,  C12Q1/6883 ,  C12Q2523/313 ,  C12Q2525/313 ,  G01N21/33 ,  G01N30/06 ,  G01N2030/8827 ,  Y10T436/143333

摘要： Disclosed are compositions which can mimic DNA and/or RNA in cells of a subject and methods of using them as a substrate in testing efficacy of one or more compositions in reducing and/or preventing radiation, such as ultraviolet (UV) radiation-caused DNA and/or RNA damage of said subject. Also disclosed are systems related to the disclosed methods.

摘要翻译： 公开了可以模拟受试者细胞中的DNA和/或RNA的组合物以及在测试一种或多种组合物在减少和/或预防辐射中的功效（例如紫外线（UV）辐射引起的DNA）中使用它们作为底物的方法 和/或所述受试者的RNA损伤。 还公开了与所公开的方法相关的系统。

公开(公告)号：US08427274B2

公开(公告)日：2013-04-23

申请号：US12344054

申请日：2008-12-24

申请人： Scott A. Jones ,  Zhen Huang ,  Paul W. Bonham ,  Chuan Li ,  Cameron D. Jiles

发明人： Scott A. Jones ,  Zhen Huang ,  Paul W. Bonham ,  Chuan Li ,  Cameron D. Jiles

IPC分类号： G05B23/02 ,  G09G5/00 ,  G03B15/02 ,  F21V7/04

CPC分类号： H05B37/029

摘要： The present invention is related to a method, system and apparatus, in particular, a lighting system and method of controlling the lighting system, comprising a computer readable medium and a programmable device capable of controlling and manipulating individually addressable lights to realize a visual display at a pixel level.

摘要翻译： 本发明涉及一种方法，系统和装置，特别是控制照明系统的照明系统和方法，包括计算机可读介质和可编程设备，其能够控制和操纵单独寻址的光以实现视觉显示 像素级别。

公开(公告)号：US20130035028A1

公开(公告)日：2013-02-07

申请号：US13638607

申请日：2011-03-25

申请人： Jianghong Zhu ,  Hui Zhang ,  Shaolin Chen ,  Huanlong Wu ,  Liang Li ,  Zhen Huang ,  Jianqun Yang ,  Wenwei Ji ,  Zhi Meng ,  Jian Li ,  Liu Cao

发明人： Jianghong Zhu ,  Hui Zhang ,  Shaolin Chen ,  Huanlong Wu ,  Liang Li ,  Zhen Huang ,  Jianqun Yang ,  Wenwei Ji ,  Zhi Meng ,  Jian Li ,  Liu Cao

IPC分类号： F25D17/06 ,  F24H3/06 ,  F24F7/06

CPC分类号： F24F1/0007 ,  F24F13/20 ,  F24F2221/26

摘要： An indoor unit of air conditioner comprises a panel body (2) enclosing side portions and a top portion of the air conditioner, a rear shell enclosing a rear portion of the air conditioner, and the front panel (1) arranged in the front of the air conditioner and closely connected to the panel body (2). The rear shell, the panel body (2) and the front panel (1) form an inner chamber of the air conditioner in which a heat exchanger, a control element and a fan component are provided. Side surfaces of the indoor unit of air conditioner are of a U shape structure, and the front, the rear and the bottom surfaces of the lower portion of the indoor unit of air conditioner are formed by more than one curved surface.

摘要翻译： 空调机的室内机包括封闭侧部的面板体（2）和空调机的顶部，包围空调机的后部的后壳以及配置在空调机的前方的前面板（1） 空调，并紧密连接到面板主体（2）。 后壳体，面板体（2）和前面板（1）形成空调机的内室，其中设置有热交换器，控制元件和风扇部件。 空调机的室内机的侧面为U形结构，空调机的室内机的下部的前表面，后表面和底面由多于一个的曲面形成。

公开(公告)号：US08354524B2

公开(公告)日：2013-01-15

申请号：US13172559

申请日：2011-06-29

申请人： Zhen Huang

发明人： Zhen Huang

IPC分类号： C07D239/47 ,  C07D421/04 ,  C07H19/073 ,  C07H21/04 ,  A61K31/506 ,  A61K48/00

CPC分类号： C07H19/06 ,  C07H5/08 ,  C07H19/10 ,  C07H19/16 ,  C07H19/20 ,  C07H21/00

摘要： The present invention provides selenium derivatives of nucleosides, nucleoside phosphoramidites, nucleotides, nucleotide triphosphates, oligonucleotides, polynucleotides, and larger nucleic acids and methods for their synthesis. Selenium derivatives of both ribonucleic acids and deoxyribonucleic acids, as well as methods for their synthesis, crystallization and uses in structural determinations, particularly by X-ray crystallographic techniques are disclosed. The selenium derivatives of the present invention are also useful as food supplements.

摘要翻译： 本发明提供了核苷，核苷亚磷酰胺，核苷酸，核苷酸三磷酸，寡核苷酸，多核苷酸和较大的核酸的硒衍生物及其合成方法。 公开了核糖核酸和脱氧核糖核酸的硒衍生物，以及它们的合成，结晶和用于结构测定的方法，特别是通过X射线晶体学技术。 本发明的硒衍生物也可用作食品添加剂。

公开(公告)号：US20120243871A1

公开(公告)日：2012-09-27

申请号：US13053925

申请日：2011-03-22

申请人： Zhen Huang ,  David Hood

发明人： Zhen Huang ,  David Hood

IPC分类号： H04J14/00

CPC分类号： H04B10/116 ,  H04B10/272 ,  H04J14/0267 ,  H04J14/0282 ,  H04Q11/0067 ,  H04Q2011/0079 ,  H04W52/0225 ,  H04W52/0229 ,  H04W52/0274 ,  H04W52/0296 ,  Y02D70/00 ,  Y02D70/1222 ,  Y02D70/1262 ,  Y02D70/146 ,  Y02D70/23 ,  Y02D70/46

摘要： The embodiments herein relate to a method in an optical network unit (103), referred to as an ONU, for providing wireless connectivity capability to the ONU (103). The ONU (103) is comprised in a communications network (100). The ONU (103) is interconnected to an optical line terminal (101), referred to as an OLT, via a wireline communications link (104) and a wireless communications link (113). The ONU (103) is configured to support a sleep mode. The ONU (103) obtains information about entry into the sleep mode. The ONU (103) identifies whether the wireless communications link (113) is activated or deactivated, and activates the wireless communications link (113) if the wireless communications link (113) is identified as deactivated. The ONU (103) enters sleep mode, and provides wireless connectivity capability to the ONU (103) by means of the wireless communications link during the sleep mode.

摘要翻译： 本文的实施例涉及用于向ONU（103）提供无线连接能力的光网络单元（103）中的称为ONU的方法。 ONU（103）包括在通信网络（100）中。 ONU（103）经由有线通信链路（104）和无线通信链路（113）互连到被称为OLT的光线路终端（101）。 ONU（103）被配置为支持睡眠模式。 ONU（103）获取关于进入睡眠模式的信息。 如果无线通信链路（113）被识别为去激活，则ONU（103）识别无线通信链路（113）是否被激活或去激活，并激活无线通信链路（113）。 ONU（103）进入睡眠模式，并且在睡眠模式期间通过无线通信链路向ONU（103）提供无线连接能力。

公开(公告)号：US20120070825A1

公开(公告)日：2012-03-22

申请号：US13321544

申请日：2010-05-20

申请人： Zhen Huang

发明人： Zhen Huang

IPC分类号： C12Q1/68 ,  C07H1/02 ,  C07H21/00 ,  C07H21/04 ,  G01N23/207 ,  G01N21/75 ,  C07H21/02 ,  G01N30/02 ,  H01J49/00 ,  C07H19/073 ,  C07H23/00

CPC分类号： C07H21/00 ,  C07H19/06

摘要： Disclosed are compounds of formula (I), a derivative, or a tautomer thereof, or a pharmaceutically acceptable salt of said compound or said tautomer. Also disclosed are methods of preparing compound of formula (I), a derivative, or a tautomer thereof, or a pharmaceutically acceptable salt of said compound or said tautomer. Further disclosed are methods of conducting drug discovery and research comprises applying the compound of formula (I), a derivative, or a tautomer thereof, or a pharmaceutically acceptable salt of said compound or said tautomer in an investigation.

摘要翻译： 公开了式（I）的化合物，其衍生物或互变异构体，或所述化合物或所述互变异构体的药学上可接受的盐。 还公开了制备式（I）化合物，其衍生物或其互变异构体或所述化合物或所述互变异构体的药学上可接受的盐的方法。 进一步披露的是进行药物发现和研究的方法包括在调查中应用式（I）化合物，其衍生物或互变异构体，或所述化合物或所述互变异构体的药学上可接受的盐。