发明授权
- 专利标题: Antibodies to the NOTCH1 receptor
- 专利标题(中): NOTCH1受体的抗体
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申请号: US13472301申请日: 2012-05-15
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公开(公告)号: US08404237B2公开(公告)日: 2013-03-26
- 发明人: John A. Lewicki , Austin Gurney , Timothy Hoey , Wan-ching Yen , Sanjeev Satyal
- 申请人: John A. Lewicki , Austin Gurney , Timothy Hoey , Wan-ching Yen , Sanjeev Satyal
- 申请人地址: US CA Redwood City
- 专利权人: OncoMed Pharamaceuticals, Inc.
- 当前专利权人: OncoMed Pharamaceuticals, Inc.
- 当前专利权人地址: US CA Redwood City
- 代理机构: Sterne, Kessler, Goldstein & Fox P.L.L.C.
- 主分类号: A61K39/395
- IPC分类号: A61K39/395 ; C07K16/28 ; C07K14/705 ; C12N5/07
摘要:
The present invention relates to compositions and methods for characterizing, diagnosing, and treating cancer. In particular the invention provides the means and methods for the diagnosis, characterization, prognosis and treatment of cancer and specifically targeting cancer stem cells. The present invention provides an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human NOTCH receptor and inhibits growth of tumor cells. The present invention further provides a method of treating cancer, the method comprising administering a therapeutically effective amount of an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human NOTCH receptor protein and inhibits growth of tumor cells.
公开/授权文献
- US20130030155A1 ANTIBODIES TO THE NOTCH1 RECEPTOR 公开/授权日:2013-01-31