公开(公告)号：US08404237B2

公开(公告)日：2013-03-26

申请号：US13472301

申请日：2012-05-15

申请人： John A. Lewicki ,  Austin Gurney ,  Timothy Hoey ,  Wan-ching Yen ,  Sanjeev Satyal

发明人： John A. Lewicki ,  Austin Gurney ,  Timothy Hoey ,  Wan-ching Yen ,  Sanjeev Satyal

IPC分类号： A61K39/395 ,  C07K16/28 ,  C07K14/705 ,  C12N5/07

CPC分类号： C07K16/30 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/507 ,  A61N5/10 ,  C07K16/18 ,  C07K16/28 ,  C07K16/3015 ,  C07K16/3046 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76 ,  C07K2317/92

摘要： The present invention relates to compositions and methods for characterizing, diagnosing, and treating cancer. In particular the invention provides the means and methods for the diagnosis, characterization, prognosis and treatment of cancer and specifically targeting cancer stem cells. The present invention provides an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human NOTCH receptor and inhibits growth of tumor cells. The present invention further provides a method of treating cancer, the method comprising administering a therapeutically effective amount of an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human NOTCH receptor protein and inhibits growth of tumor cells.

摘要翻译： 本发明涉及用于表征，诊断和治疗癌症的组合物和方法。 特别地，本发明提供了用于癌症的诊断，表征，预后和治疗以及特异性靶向癌症干细胞的方法和方法。 本发明提供了特异性结合人类NOTCH受体的细胞外结构域的非配体结合区并抑制肿瘤细胞生长的抗体。 本发明还提供了一种治疗癌症的方法，所述方法包括施用治疗有效量的特异性结合人NOTCH受体蛋白的细胞外结构域的非配体结合区的抗体并抑制肿瘤细胞的生长。