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公开(公告)号：US20080131434A1
公开(公告)日：2008-06-05
申请号：US11806472
申请日：2007-05-31
申请人： John A. Lewicki , Austin Gurney , Timothy Hoey , Wan-Ching Yen , Sanjeev Satyal
发明人： John A. Lewicki , Austin Gurney , Timothy Hoey , Wan-Ching Yen , Sanjeev Satyal
IPC分类号： A61K39/395 , C07K16/28 , C07H21/00 , G01N33/574 , C12P21/00
CPC分类号： C07K16/30 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61K2039/507 , A61N5/10 , C07K16/18 , C07K16/28 , C07K16/3015 , C07K16/3046 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to compositions and methods for characterizing, diagnosing, and treating cancer. In particular the invention provides the means and methods for the diagnosis, characterization, prognosis and treatment of cancer and specifically targeting cancer stem cells. The present invention provides an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human NOTCH receptor and inhibits growth of tumor cells. The present invention further provides a method of treating cancer, the method comprising administering a therapeutically effective amount of an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human NOTCH receptor protein and inhibits growth of tumor cells.
摘要翻译： 本发明涉及用于表征，诊断和治疗癌症的组合物和方法。 特别地，本发明提供了用于癌症的诊断，表征，预后和治疗以及特异性靶向癌症干细胞的方法和方法。 本发明提供了特异性结合人类NOTCH受体的细胞外结构域的非配体结合区并抑制肿瘤细胞生长的抗体。 本发明还提供了一种治疗癌症的方法，所述方法包括施用治疗有效量的特异性结合人NOTCH受体蛋白的细胞外结构域的非配体结合区的抗体并抑制肿瘤细胞的生长。
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公开(公告)号：US08404237B2
公开(公告)日：2013-03-26
申请号：US13472301
申请日：2012-05-15
申请人： John A. Lewicki , Austin Gurney , Timothy Hoey , Wan-ching Yen , Sanjeev Satyal
发明人： John A. Lewicki , Austin Gurney , Timothy Hoey , Wan-ching Yen , Sanjeev Satyal
IPC分类号： A61K39/395 , C07K16/28 , C07K14/705 , C12N5/07
CPC分类号： C07K16/30 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61K2039/507 , A61N5/10 , C07K16/18 , C07K16/28 , C07K16/3015 , C07K16/3046 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to compositions and methods for characterizing, diagnosing, and treating cancer. In particular the invention provides the means and methods for the diagnosis, characterization, prognosis and treatment of cancer and specifically targeting cancer stem cells. The present invention provides an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human NOTCH receptor and inhibits growth of tumor cells. The present invention further provides a method of treating cancer, the method comprising administering a therapeutically effective amount of an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human NOTCH receptor protein and inhibits growth of tumor cells.
摘要翻译： 本发明涉及用于表征，诊断和治疗癌症的组合物和方法。 特别地，本发明提供了用于癌症的诊断，表征，预后和治疗以及特异性靶向癌症干细胞的方法和方法。 本发明提供了特异性结合人类NOTCH受体的细胞外结构域的非配体结合区并抑制肿瘤细胞生长的抗体。 本发明还提供了一种治疗癌症的方法，所述方法包括施用治疗有效量的特异性结合人NOTCH受体蛋白的细胞外结构域的非配体结合区的抗体并抑制肿瘤细胞的生长。
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3.发明授权Method of treating cancer using antibodies to a non-ligand binding region of NOTCH2 有权使用NOTCH2非配体结合区域的抗体治疗癌症的方法公开(公告)号：US08206713B2
公开(公告)日：2012-06-26
申请号：US13010486
申请日：2011-01-20
申请人： John A. Lewicki , Austin Gurney , Timothy Hoey , Wan-ching Yen , Sanjeev Satyal
发明人： John A. Lewicki , Austin Gurney , Timothy Hoey , Wan-ching Yen , Sanjeev Satyal
IPC分类号： A61K39/395 , C07K16/28 , C07K14/705
CPC分类号： C07K16/30 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61K2039/507 , A61N5/10 , C07K16/18 , C07K16/28 , C07K16/3015 , C07K16/3046 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to compositions and methods for characterizing, diagnosing, and treating cancer. In particular the invention provides the means and methods for the diagnosis, characterization, prognosis and treatment of cancer and specifically targeting cancer stem cells. The present invention provides an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human NOTCH receptor and inhibits growth of tumor cells. The present invention further provides a method of treating cancer, the method comprising administering a therapeutically effective amount of an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human NOTCH receptor protein and inhibits growth of tumor cells.
摘要翻译： 本发明涉及用于表征，诊断和治疗癌症的组合物和方法。 特别地，本发明提供了用于癌症的诊断，表征，预后和治疗以及特异性靶向癌症干细胞的方法和方法。 本发明提供了特异性结合人类NOTCH受体的细胞外结构域的非配体结合区并抑制肿瘤细胞生长的抗体。 本发明还提供了一种治疗癌症的方法，所述方法包括施用治疗有效量的特异性结合人NOTCH受体蛋白的细胞外结构域的非配体结合区的抗体并抑制肿瘤细胞的生长。
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公开(公告)号：US07919092B2
公开(公告)日：2011-04-05
申请号：US11806472
申请日：2007-05-31
申请人： John A. Lewicki , Austin Gurney , Timothy Hoey , Wan-Ching Yen , Sanjeev Satyal
发明人： John A. Lewicki , Austin Gurney , Timothy Hoey , Wan-Ching Yen , Sanjeev Satyal
IPC分类号： A61K39/395 , C07K16/28 , C12P21/08 , C07K14/705
CPC分类号： C07K16/30 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61K2039/507 , A61N5/10 , C07K16/18 , C07K16/28 , C07K16/3015 , C07K16/3046 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to compositions and methods for characterizing, diagnosing, and treating cancer. In particular the invention provides the means and methods for the diagnosis, characterization, prognosis and treatment of cancer and specifically targeting cancer stem cells. The present invention provides an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human NOTCH receptor and inhibits growth of tumor cells. The present invention further provides a method of treating cancer, the method comprising administering a therapeutically effective amount of an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human NOTCH receptor protein and inhibits growth of tumor cells.
摘要翻译： 本发明涉及用于表征，诊断和治疗癌症的组合物和方法。 特别地，本发明提供了用于癌症的诊断，表征，预后和治疗以及特异性靶向癌症干细胞的方法和方法。 本发明提供了特异性结合人类NOTCH受体的细胞外结构域的非配体结合区并抑制肿瘤细胞生长的抗体。 本发明还提供了一种治疗癌症的方法，所述方法包括施用治疗有效量的特异性结合人NOTCH受体蛋白的细胞外结构域的非配体结合区的抗体并抑制肿瘤细胞的生长。
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公开(公告)号：US20120288496A1
公开(公告)日：2012-11-15
申请号：US13472305
申请日：2012-05-15
申请人： Austin L. GURNEY , Timothy Charles Hoey , Edward Thein Htun van der Horst , Aaron Ken Sato , Yuan Ching Liu , Maureen Fitch Bruhns , John A. Lewicki
发明人： Austin L. GURNEY , Timothy Charles Hoey , Edward Thein Htun van der Horst , Aaron Ken Sato , Yuan Ching Liu , Maureen Fitch Bruhns , John A. Lewicki
IPC分类号： A61K39/395 , A61P35/00 , A61P9/00 , C12N5/09
CPC分类号： C07K16/22 , A61K31/337 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61N5/10 , C07H21/04 , C07K14/435 , C07K14/71 , C07K16/28 , C07K16/30 , C07K16/3046 , C07K16/462 , C07K16/464 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92 , C12N5/0693 , C12N5/12 , C12N15/63 , C12N15/79 , C12N2501/998
摘要： The present invention relates to Notch-binding agents and Notch antagonists and methods of using the agents and/or antagonists for treating diseases such as cancer. The present invention provides antibodies that specifically bind to a non-ligand binding region of the extracellular domain of one or more human Notch receptor, such as Notch2 and/or Notch3, and inhibit tumor growth. The present invention further provides methods of treating cancer, the methods comprising administering a therapeutically effective amount of an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human Notch receptor protein and inhibits tumor growth.
摘要翻译： 本发明涉及Notch结合剂和Notch拮抗剂以及使用这些药剂和/或拮抗剂治疗诸如癌症的疾病的方法。 本发明提供了特异性结合一种或多种人Notch受体如Notch2和/或Notch3的细胞外结构域的非配体结合区并抑制肿瘤生长的抗体。 本发明还提供了治疗癌症的方法，所述方法包括施用治疗有效量的特异性结合人Notch受体蛋白的细胞外结构域的非配体结合区的抗体并抑制肿瘤生长。
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6.发明授权公开(公告)号：US07833791B2
公开(公告)日：2010-11-16
申请号：US11938044
申请日：2007-11-09
IPC分类号： C12N15/00
CPC分类号： C07K14/335 , A61K35/747 , A61K38/164 , A61K38/1774 , C12N15/74
摘要： The present invention relates to Lactobacillus species recombinantly altered to express a biologically active protein. The invention also related to methods of providing the bacteria to the vagina.
摘要翻译： 本发明涉及重组改变以表达生物活性蛋白质的乳杆菌属物种。 本发明还涉及将细菌提供给阴道的方法。
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公开(公告)号：US07179790B2
公开(公告)日：2007-02-20
申请号：US11234424
申请日：2005-09-23
IPC分类号： A61K38/00
CPC分类号： C12P21/02 , A61K38/00 , C07K14/58 , C07K14/582 , C07K16/241 , C07K16/2803 , C07K2317/622 , G01N33/74
摘要： Peptides comprising the effective portion of human brain natriuretic peptide are provided in pharmaceutical compositions and methods to effect vasodilation and/or natriuresis.
摘要翻译： 包含人脑钠肽的有效部分的肽在药物组合物和方法中提供以实现血管舒张和/或利尿。
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公开(公告)号：US06541477B2
公开(公告)日：2003-04-01
申请号：US09796997
申请日：2001-02-28
申请人： R. Richard Goehring , Babu J. Mavunkel , David Y. Liu , George F. Schreiner , Gregory Leudtke , John A. Lewicki
发明人： R. Richard Goehring , Babu J. Mavunkel , David Y. Liu , George F. Schreiner , Gregory Leudtke , John A. Lewicki
IPC分类号： A61K31495
CPC分类号： C07D215/04 , A61K31/00 , A61K31/426 , A61K31/445 , A61K31/4535 , A61K31/454 , A61K31/4545 , A61K31/4709 , A61K31/495 , A61K31/496 , A61K31/522 , A61K31/5377 , A61K45/06 , C07D209/08 , C07D211/14 , C07D211/16 , C07D215/06 , C07D235/06 , C07D277/52 , C07D295/192 , C07D307/68 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/06 , C07D471/04 , C07D471/10 , C07D473/06 , C07D495/04
摘要： The invention is directed to methods for treating conditions mediated by by P38&agr; kinase using compounds of the formula wherein Ar1 and Ph are limited to specific embodiments or wherein the compound of formula (3) is a compound set forth in FIGS. 1A-1T.
摘要翻译： 本发明涉及用于治疗由P38α激酶介导的病症的方法，其中使用化学式Ar1和Ph的化合物限于具体实施方案或其中式（3）化合物是图1和图2所示的化合物。 1A-1T。
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公开(公告)号：US5258368A
公开(公告)日：1993-11-02
申请号：US875085
申请日：1992-04-28
CPC分类号： C12N15/85 , C07K14/58 , C07K14/582 , C12N15/70 , C12N15/81 , A61K38/00 , C07K2319/02 , C07K2319/036 , C07K2319/50 , C07K2319/75 , C12N2830/00 , C12N2830/002 , C12N2830/15 , C12N2830/55 , C12N2830/85
摘要： Methods, compounds and compositions are provided for inducing natriuresis, diuresis and vasodilatation in mammalian hosts by administering atrial natriuretic/vasodilator peptides to said host. Also provided are methods for producing such peptide compounds.
摘要翻译： 提供方法，化合物和组合物，用于通过向所述宿主施用心房钠尿素/血管舒张肽来在哺乳动物宿主中诱导利尿，利尿和血管扩张。 还提供了生产这种肽化合物的方法。
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公开(公告)号：US4764504A
公开(公告)日：1988-08-16
申请号：US766030
申请日：1985-05-08
IPC分类号： A61K38/00 , C07K14/58 , C12N15/62 , C12N15/70 , C12N15/81 , C12N15/85 , A61K37/02 , C07K7/10
CPC分类号： C12N15/625 , C07K14/58 , C07K14/582 , C12N15/70 , C12N15/81 , C12N15/85 , A61K38/00 , C07K2319/02 , C07K2319/036 , C07K2319/50 , C07K2319/75
摘要： Methods and compositions are provided for inducing natriuresis, diuresis and vasodilatation in mammalian hosts by administering atrial natriuretic/vasodilator polypeptides to said host. Also provided are methods for producing such polypeptides, and antibodies which are capable of recognizing and specifically binding to them.
摘要翻译： PCT No.PCT / US85 / 00658 Sec。 371日期1985年5月8日 102（e）1985年5月8日PCT提交1985年4月16日PCT公布。 公开号WO85 / 04870 日期为1985年11月7日。提供了通过向所述宿主施用心房钠尿素/血管扩张剂多肽来诱导哺乳动物宿主中的利尿，利尿和血管舒张的方法和组合物。 还提供了用于产生这种多肽的方法，以及能够识别和特异性结合它们的抗体。
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