发明授权
- 专利标题： Antibiotic macrocycle compounds and methods of manufacture and use thereof
- 专利标题（中）： 抗生素大环化合物及其制备和使用方法
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申请号： US13280148申请日： 2011-10-24
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公开(公告)号： US08445654B2公开(公告)日： 2013-05-21
- 发明人: Yoshi Ichikawa , Yu-Hung Chiu , Youe-Kong Shue , Farah Kondori Babakhani
- 申请人： Yoshi Ichikawa , Yu-Hung Chiu , Youe-Kong Shue , Farah Kondori Babakhani
- 申请人地址： US NJ Jersey City
- 专利权人： Optimer Pharmaceuticals, Inc.
- 当前专利权人： Optimer Pharmaceuticals, Inc.
- 当前专利权人地址： US NJ Jersey City
- 代理机构： Morgan, Lewis & Bockius LLP
- 主分类号： C07H17/08
- IPC分类号： C07H17/08
摘要：
The invention encompasses an active metabolite of the 18-membered macrocyclic antimicrobial agents, specifically, a metabolite of tiacumicin B and in certain embodiments, R-Tiacumicin B or and its related compounds. In particular, the invention encompasses a compound that acts as a potent antibiotic agent for the treatment of bacterial infections, specifically GI infections caused by toxin producing strains of Clostridium difficile (C. difficile) and Clostridium perfringens (C. perfringens).
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