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1.发明授权Macrocyclic polymorphs, compositions comprising such polymorphs, and methods of use and manufacture thereof 有权大环多晶型物，包含这种多晶型物的组合物，及其使用和制造方法公开(公告)号：US08859510B2
公开(公告)日：2014-10-14
申请号：US12523790
申请日：2008-01-22
申请人： Yu-Hung Chiu , Tessie Mary Che , Alex Romero , Yoshi Ichikawa , Youe-Kong Shue
发明人： Yu-Hung Chiu , Tessie Mary Che , Alex Romero , Yoshi Ichikawa , Youe-Kong Shue
IPC分类号： A61K31/7048 , C07D407/14 , C07H17/08
CPC分类号： C07H17/08 , C07D407/14
摘要： The invention relates to novel forms of compounds displaying broad spectrum antibiotic activity, especially crystalline polymorphic forms and amorphous forms of such compounds, compositions comprising such crystalline polymorphic forms and amorphous forms of such compounds, processes for manufacture and use thereof. The compounds and compositions of the invention are useful in the pharmaceutical industry, for example, in the treatment or prevention of diseases or disorders associated with the use of antibiotics, chemotherapies, or antiviral therapies, including, but not limited to, colitis, for example, pseudo-membranous colitis; antibiotic associated diarrhea; and infections due to Clostridium difficile (“C. difficile”), Clostridium perfringens (“C. perfringens”), Staphylococcus species, for example, methicillin-resistant Staphylococcus, or Enterococcus including Vancomycin-resistant enterococci.
摘要翻译： 本发明涉及显示广谱抗生素活性的化合物的新形式，特别是结晶多晶形式和这种化合物的无定形形式，包含这种结晶多晶形式的组合物和这种化合物的无定形形式，其制备和使用方法。 本发明的化合物和组合物可用于制药工业，例如用于治疗或预防与使用抗生素，化学疗法或抗病毒疗法相关的疾病或病症，包括但不限于结肠炎，例如 ，假膜性结肠炎; 抗生素相关性腹泻; 和艰难梭菌（“艰难梭菌”），产气荚膜梭菌（“产气荚膜梭菌”），葡萄球菌属，例如耐甲氧西林葡萄球菌或包括耐万古霉素肠球菌在内的肠球菌引起的感染。
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2.发明授权公开(公告)号：US08445654B2
公开(公告)日：2013-05-21
申请号：US13280148
申请日：2011-10-24
IPC分类号： C07H17/08
CPC分类号： C07H17/08 , A61K31/70 , A61K31/7048
摘要： The invention encompasses an active metabolite of the 18-membered macrocyclic antimicrobial agents, specifically, a metabolite of tiacumicin B and in certain embodiments, R-Tiacumicin B or and its related compounds. In particular, the invention encompasses a compound that acts as a potent antibiotic agent for the treatment of bacterial infections, specifically GI infections caused by toxin producing strains of Clostridium difficile (C. difficile) and Clostridium perfringens (C. perfringens).
摘要翻译： 本发明包括18-元大环抗微生物剂的活性代谢物，具体地，一种泰克霉素B的代谢物，并且在某些实施方案中，R-Tyacumicin B或其相关化合物。 特别地，本发明包括用作治疗细菌感染的有效抗生素的化合物，特别是由艰难梭菌（艰难梭菌）和产气荚膜梭菌（产气荚膜梭菌）的毒素产生菌株引起的GI感染。
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3.发明申请公开(公告)号：US20080194497A1
公开(公告)日：2008-08-14
申请号：US12101552
申请日：2008-04-11
申请人： Yu-Hung Chiu , Tessie Mary Che , Alex Romero , Yoshi Ichikawa , Youe-Kong Shue
发明人： Yu-Hung Chiu , Tessie Mary Che , Alex Romero , Yoshi Ichikawa , Youe-Kong Shue
IPC分类号： A61K31/7048 , C07H17/08
CPC分类号： C07H17/08 , C07D407/14
摘要： The invention relates to novel forms of compounds displaying broad spectrum antibiotic activity, especially crystalline polymorphic forms and amorphous forms of such compounds, compositions comprising such crystalline polymorphic forms and amorphous forms of such compounds, processes for manufacture and use thereof. The compounds and compositions of the invention are useful in the pharmaceutical industry, for example, in the treatment or prevention of diseases or disorders associated with the use of antibiotics, chemotherapies, or antiviral therapies, including, but not limited to, colitis, for example, pseudo-membranous colitis; antibiotic associated diarrhea; and infections due to Clostridium difficile (“C. difficile”), Clostridium perfringens (“C. perfringens”), Staphylococcus species, for example, methicillin-resistant Staphylococcus, or Enterococcus including Vancomycin-resistant enterococci.
摘要翻译： 本发明涉及显示广谱抗生素活性的化合物的新形式，特别是结晶多晶形式和这种化合物的无定形形式，包含这种结晶多晶形式的组合物和这种化合物的无定形形式，其制备和使用方法。 本发明的化合物和组合物可用于制药工业，例如用于治疗或预防与使用抗生素，化学疗法或抗病毒疗法相关的疾病或病症，包括但不限于结肠炎，例如 ，假膜性结肠炎; 抗生素相关性腹泻; 和艰难梭菌（“艰难梭菌”），产气荚膜梭菌（“产气荚膜梭菌”），葡萄球菌属，例如耐甲氧西林葡萄球菌或包括耐万古霉素肠球菌在内的肠球菌引起的感染。
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4.发明授权公开(公告)号：US08044030B2
公开(公告)日：2011-10-25
申请号：US12324907
申请日：2008-11-28
CPC分类号： C07H17/08 , A61K31/70 , A61K31/7048
摘要： The invention encompasses an active metabolite of the 18-membered macrocyclic antimicrobial agents, specifically, a metabolite of tiacumicin B and in certain embodiments, R-Tiacumicin B or and its related compounds. In particular, the invention encompasses a compound that acts as a potent antibiotic agent for the treatment of bacterial infections, specifically GI infections caused by toxin producing strains of Clostridium difficile (C. difficile) and Clostridium perfringens (C. perfringens).
摘要翻译： 本发明包括18-元大环抗微生物剂的活性代谢物，具体地，一种泰克霉素B的代谢物，并且在某些实施方案中，R-Tyacumicin B或其相关化合物。 特别地，本发明包括用作治疗细菌感染的有效抗生素的化合物，特别是由艰难梭菌（艰难梭菌）和产气荚膜梭菌（产气荚膜梭菌）产生毒素的菌株引起的GI感染。
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5.发明申请Macrocyclic Polymorphs, Compositions Comprising Such Polymorphs and Methods of Use and Manufacture Thereof 有权大环多晶型物，包含这种多晶型物的组合物及其使用和制造方法公开(公告)号：US20100010076A1
公开(公告)日：2010-01-14
申请号：US12552919
申请日：2009-09-02
申请人： Yu-Hung CHIU , Tessie Mary Che , Alex Romero , Yoshi Ichikawa , Youe-Kong Shue
发明人： Yu-Hung CHIU , Tessie Mary Che , Alex Romero , Yoshi Ichikawa , Youe-Kong Shue
IPC分类号： A61K31/351
CPC分类号： A61K31/351
摘要： The invention relates to novel forms of compounds displaying broad spectrum antibiotic activity, especially crystalline polymorphic forms and amorphous forms of such compounds, compositions comprising such crystalline polymorphic forms and amorphous forms of such compounds, processes for manufacture and use thereof. The compounds and compositions of the invention are useful in the pharmaceutical industry, for example, in the treatment or prevention of diseases or disorders associated with the use of antibiotics, chemotherapies, or antiviral therapies, including, but not limited to, colitis, for example, pseudo-membranous colitis; antibiotic associated diarrhea; and infections due to Clostridium difficile (“C. difficile”), Clostridium perfringens (“C. perfringens”), Staphylococcus species, for example, methicillin-resistant Staphylococcus, or Enterococcus including Vancomycin-resistant enterococci.
摘要翻译： 本发明涉及显示广谱抗生素活性的化合物的新形式，特别是结晶多晶形式和这种化合物的无定形形式，包含这种结晶多晶形式的组合物和这种化合物的无定形形式，其制备和使用方法。 本发明的化合物和组合物可用于制药工业，例如用于治疗或预防与使用抗生素，化学疗法或抗病毒疗法相关的疾病或病症，包括但不限于结肠炎，例如 ，假膜性结肠炎; 抗生素相关性腹泻; 和艰难梭菌（“艰难梭菌”），产气荚膜梭菌（“产气荚膜梭菌”），葡萄球菌属，例如耐甲氧西林葡萄球菌或包括耐万古霉素肠球菌在内的肠球菌引起的感染。
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6.发明授权Macrolide polymorphs, compositions comprising such polymorphs, and methods of use and manufacture thereof 有权大环内酯多晶型物，包含这种多晶型物的组合物，及其使用和制造方法公开(公告)号：US08883986B2
公开(公告)日：2014-11-11
申请号：US12397686
申请日：2009-03-04
申请人： Yu-Hung Chiu , Tessie Mary Che , Alex Romero , Yoshi Ichikawa , Youe-Kong Shue
发明人： Yu-Hung Chiu , Tessie Mary Che , Alex Romero , Yoshi Ichikawa , Youe-Kong Shue
IPC分类号： C07H17/08
CPC分类号： C07H17/08 , C07D407/14
摘要： The invention relates to novel forms of compounds displaying broad spectrum antibiotic activity, especially crystalline polymorphic forms and amorphous forms of such compounds, compositions comprising such crystalline polymorphic forms and amorphous forms of such compounds, processes for manufacture and use thereof. The compounds and compositions of the invention are useful in the pharmaceutical industry, for example, in the treatment or prevention of diseases or disorders associated with the use of antibiotics, chemotherapies, or antiviral therapies, including, but not limited to, colitis, for example, pseudo-membranous colitis; antibiotic associated diarrhea; and infections due to Clostridium difficile (“C. difficile”), Clostridium perfringens (“C. perfringens”), Staphylococcus species, for example, methicillin-resistant Staphylococcus, or Enterococcus including Vancomycin-resistant enterococci.
摘要翻译： 本发明涉及显示广谱抗生素活性的化合物的新形式，特别是结晶多晶形式和这种化合物的无定形形式，包含这种结晶多晶形式的组合物和这种化合物的无定形形式，其制备和使用方法。 本发明的化合物和组合物可用于制药工业，例如用于治疗或预防与使用抗生素，化学疗法或抗病毒疗法相关的疾病或病症，包括但不限于结肠炎，例如 ，假膜性结肠炎; 抗生素相关性腹泻; 和艰难梭菌（“艰难梭菌”），产气荚膜梭菌（“产气荚膜梭菌”），葡萄球菌属，例如耐甲氧西林葡萄球菌或包括耐万古霉素肠球菌在内的肠球菌引起的感染。
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7.发明申请MACROCYCLIC POLYMORPHS, COMPOSITIONS COMPRISING SUCH POLYMORPHS, AND METHODS OF USE AND MANUFACTURE THEREOF 有权大分子聚合物，包含这种聚合物的组合物及其使用和制造方法公开(公告)号：US20100081800A1
公开(公告)日：2010-04-01
申请号：US12523790
申请日：2008-01-22
申请人： Yu-Hung Chiu , Tessie Mary Che , Alex Romero , Yoshi Ichikawa , Youe-Kong Shue
发明人： Yu-Hung Chiu , Tessie Mary Che , Alex Romero , Yoshi Ichikawa , Youe-Kong Shue
IPC分类号： C07H17/08
CPC分类号： C07H17/08 , C07D407/14
摘要： The invention relates to novel forms of compounds displaying broad spectrum antibiotic activity, especially crystalline polymorphic forms and amorphous forms of such compounds, compositions comprising such crystalline polymorphic forms and amorphous forms of such compounds, processes for manufacture and use thereof. The compounds and compositions of the invention are useful in the pharmaceutical industry, for example, in the treatment or prevention of diseases or disorders associated with the use of antibiotics, chemotherapies, or antiviral therapies, including, but not limited to, colitis, for example, pseudo-membranous colitis; antibiotic associated diarrhea; and infections due to Clostridium difficile (“C. difficile”), Clostridium perfringens (“C. perfringens”), Staphylococcus species, for example, methicillin-resistant Staphylococcus, or Enterococcus including Vancomycin-resistant enterococci.
摘要翻译： 本发明涉及显示广谱抗生素活性的化合物的新形式，特别是结晶多晶形式和这种化合物的无定形形式，包含这种结晶多晶形式的组合物和这种化合物的无定形形式，其制备和使用方法。 本发明的化合物和组合物可用于制药工业，例如用于治疗或预防与使用抗生素，化学疗法或抗病毒疗法相关的疾病或病症，包括但不限于结肠炎，例如 ，假膜性结肠炎; 抗生素相关性腹泻; 和艰难梭菌（“艰难梭菌”），产气荚膜梭菌（“产气荚膜梭菌”），葡萄球菌属，例如耐甲氧西林葡萄球菌或包括耐万古霉素肠球菌在内的肠球菌引起的感染。
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8.发明申请公开(公告)号：US20100035833A1
公开(公告)日：2010-02-11
申请号：US12324907
申请日：2008-11-28
IPC分类号： A61K31/70
CPC分类号： C07H17/08 , A61K31/70 , A61K31/7048
摘要： The invention encompasses an active metabolite of the 18-membered macrocyclic antimicrobial agents, specifically, a metabolite of tiacumicin B and in certain embodiments, R-Tiacumicin B or and its related compounds. In particular, the invention encompasses a compound that acts as a potent antibiotic agent for the treatment of bacterial infections, specifically GI infections caused by toxin producing strains of Clostridium difficile (C. difficile) and Clostridium perfringens (C. perfringens).
摘要翻译： 本发明包括18-元大环抗微生物剂的活性代谢物，具体地，一种泰克霉素B的代谢物，并且在某些实施方案中，R-Tyacumicin B或其相关化合物。 特别地，本发明包括用作治疗细菌感染的有效抗生素的化合物，特别是由艰难梭菌（艰难梭菌）和产气荚膜梭菌（产气荚膜梭菌）的毒素产生菌株引起的GI感染。
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公开(公告)号：US07601695B2
公开(公告)日：2009-10-13
申请号：US10548698
申请日：2004-03-05
申请人： Chang-Hsing Liang , Jonathan Duffield , Alex Romero , Yu-Hung Chiu , David Rabuka , Sulan Yao , Steve Sucheck , Kenneth Marby , Youe-kong Shue , Yoshi Ichikawa , Chan-Kou Hwang
发明人： Chang-Hsing Liang , Jonathan Duffield , Alex Romero , Yu-Hung Chiu , David Rabuka , Sulan Yao , Steve Sucheck , Kenneth Marby , Youe-kong Shue , Yoshi Ichikawa , Chan-Kou Hwang
CPC分类号： C07D498/04 , C07H17/08
摘要： Described herein are novel macrolides, the preparation of novel macrolides, to the use of novel macrolides for preventing, treating, or ameliorating various conditions, and the use of novel macrolides as antibacterial agents.
摘要翻译： 本文描述了新型大环内酯类，新型大环内酯类的制备，使用新型大环内酯类来预防，治疗或改善各种病症，以及使用新型大环内酯类作为抗菌剂。
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公开(公告)号：US07378508B2
公开(公告)日：2008-05-27
申请号：US11831886
申请日：2007-07-31
申请人： Yu-Hung Chiu , Tessie Mary Che , Alex Romero , Yoshi Ichikawa , Youe-Kong Shue
发明人： Yu-Hung Chiu , Tessie Mary Che , Alex Romero , Yoshi Ichikawa , Youe-Kong Shue
IPC分类号： C07H17/08 , C07D313/00
CPC分类号： C07H17/08 , C07D407/14
摘要： The invention relates to novel forms of compounds displaying broad spectrum antibiotic activity, especially crystalline polymorphic forms and amorphous forms of such compounds, compositions comprising such crystalline polymorphic forms and amorphous forms of such compounds, processes for manufacture and use thereof. The compounds and compositions of the invention are useful in the pharmaceutical industry, for example, in the treatment or prevention of diseases or disorders associated with the use of antibiotics, chemotherapies, or antiviral therapies, including, but not limited to, colitis, for example, pseudo-membranous colitis; antibiotic associated diarrhea; and infections due to Clostridium difficile (“C. difficile”), Clostridium perfringens (“C. perfringens”), Staphylococcus species, for example, methicillin-resistant Staphylococcus, or Enterococcus including Vancomycin-resistant enterococci.
摘要翻译： 本发明涉及显示广谱抗生素活性的化合物的新形式，特别是结晶多晶形式和这种化合物的无定形形式，包含这种结晶多晶形式的组合物和这种化合物的无定形形式，其制备和使用方法。 本发明的化合物和组合物可用于制药工业，例如用于治疗或预防与使用抗生素，化学疗法或抗病毒疗法相关的疾病或病症，包括但不限于结肠炎，例如 ，假膜性结肠炎; 抗生素相关性腹泻; 和艰难梭菌（“艰难梭菌”），产气荚膜梭菌（“产气荚膜梭菌”），葡萄球菌属，例如耐甲氧西林葡萄球菌或包括耐万古霉素肠球菌在内的肠球菌引起的感染。
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