Invention Grant
- Patent Title: Gamma secretase modulators
- Patent Title (中): 伽玛分泌酶调节剂
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Application No.: US12746041Application Date: 2008-12-04
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Publication No.: US08450343B2Publication Date: 2013-05-28
- Inventor: Xianhai Huang , Anandan Palani , Jun Qin , Robert G. Aslanian , Zhaoning Zhu , William Greenlee , Hubert Josien , Wei Zhou , Xiaohong Zhu , Chad E. Bennett , Dmitri Pissarnitski , Mihirbaran Mandal , Pawan Dhondi , Troy McCracken , Thomas Bara , Zhiqiang Zhao , Duane Burnett , John Clader
- Applicant: Xianhai Huang , Anandan Palani , Jun Qin , Robert G. Aslanian , Zhaoning Zhu , William Greenlee , Hubert Josien , Wei Zhou , Xiaohong Zhu , Chad E. Bennett , Dmitri Pissarnitski , Mihirbaran Mandal , Pawan Dhondi , Troy McCracken , Thomas Bara , Zhiqiang Zhao , Duane Burnett , John Clader
- Agent Susan L. Hess; Henry Jeanette; Gerard M. Devlin
- International Application: PCT/US2008/085515 WO 20081204
- International Announcement: WO2009/073777 WO 20090611
- Main IPC: A01N43/42
- IPC: A01N43/42 ; A61K31/44 ; C07D471/02 ; C07D491/02 ; C07D498/02 ; C07D513/02 ; C07D515/02
Abstract:
This invention provides novel compounds that are modulators of gamma secretase. The compounds have the formula (I) wherein R2 is a fused bicyclic ring of the formula (II). Also disclosed are methods of modulating gamma secretase activity and methods of treating Alzheimer's disease using the compounds of formula (I).
Public/Granted literature
- US20110015190A1 GAMMA SECRETASE MODULATORS Public/Granted day:2011-01-20
Information query
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