Invention Grant
- Patent Title: Process for the manufacture of bridged monobactam intermediates
- Patent Title (中): 桥联单体中间体的制备方法
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Application No.: US12676580Application Date: 2008-09-15
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Publication No.: US08450477B2Publication Date: 2013-05-28
- Inventor: Marc Muller , Xiaoping Wu , Lin Xu
- Applicant: Marc Muller , Xiaoping Wu , Lin Xu
- Applicant Address: CH Basel
- Assignee: Basilea Pharmaceutica A.G.
- Current Assignee: Basilea Pharmaceutica A.G.
- Current Assignee Address: CH Basel
- Priority: EP07116603 20070917
- International Application: PCT/EP2008/062258 WO 20080915
- International Announcement: WO2009/037229 WO 20090326
- Main IPC: C07D487/04
- IPC: C07D487/04 ; C07C271/22 ; C07C269/04

Abstract:
A process for manufacturing a compound of Formula (I) which has cis-conformation and wherein R1 represents a 1-phenyl-C1-C4alkyl or 1-naphthyl-C1-C4alkyl group, wherein the phenyl or naphthyl moiety of R1 is unsubstituted or substituted with one or more C1-C4alkoxy groups and the carbon atoms in 2-, 3-, and/or 4-position of the alkyl part of R1 are, independently of the phenyl or naphthyl moiety of R1 and independently of one another, unsubstituted or substituted with C1-C4alkoxy and/or silyloxy or, preferably, are unsubstituted or substituted with one C1-C4alkoxy group and/or silyloxy group per carbon atom, and R2 represents a C1-C6alkyl group or an unsubstituted or substituted benzyl group, in which process a compound of Formula (II) wherein R3 represents a C1-C6alkyl group or an unsubstituted or substituted benzyl group, and R1 and R2 have the same meaning as in formula (I); is treated with a base at a temperature of 0° C. or less in a liquid aprotic solvent for a time period sufficient to obtain the compound of formula (I).
Public/Granted literature
- US20110178291A1 Process for the manufacture of bridged monobactam intermediates Public/Granted day:2011-07-21
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