发明授权
US08470580B2 Method for the selection of recombination clones comprising a sequence encoding an antidote protein to a toxic molecule
有权
用于选择重组克隆的方法，其包含编码毒性分子的解毒剂蛋白质的序列
- 专利标题： Method for the selection of recombination clones comprising a sequence encoding an antidote protein to a toxic molecule
- 专利标题（中）： 用于选择重组克隆的方法，其包含编码毒性分子的解毒剂蛋白质的序列
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申请号： US10468536申请日： 2002-02-22
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公开(公告)号： US08470580B2公开(公告)日： 2013-06-25
- 发明人: Philippe Gabant , Laurence Van Melderen , Cédric Yves Szpirer
- 申请人： Philippe Gabant , Laurence Van Melderen , Cédric Yves Szpirer
- 申请人地址： BE Brussels
- 专利权人： Universite Libre de Bruxelles
- 当前专利权人： Universite Libre de Bruxelles
- 当前专利权人地址： BE Brussels
- 代理机构： Knobbe, Martens, Olson & Bear LLP
- 国际申请： PCT/BE02/00021 WO 20020222
- 国际公布： WO02/066657 WO 20020829
- 主分类号： C12N1/21
- IPC分类号： C12N1/21 ; C12N15/00 ; C07H21/04
摘要：
The present invention is related to a method for the selection of recombinant clones having integrated a gene of interest and a nucleotide sequence encoding a functional antidote protein to a toxic molecule, wherein said recombinant clones are the ones which survive following their integration into a host cell comprising in its genome a nucleotide sequence encoding said toxic molecule. The present invention is also related to a nucleic acid construct, a vector comprising said nucleic acid construct, a host cell and a cloning and/or sequencing kit for performing said method.
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