发明授权
- 专利标题: Nitrogen-containing heterocyclic compound and use thereof
- 专利标题(中): 含氮杂环化合物及其用途
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申请号: US12314015申请日: 2008-12-02
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公开(公告)号: US08470816B2公开(公告)日: 2013-06-25
- 发明人: Yoshinori Ikeura , Junya Shirai , Hideyuki Sugiyama , Yuji Nishikimi , Taku Kamei , Nobuki Sakauchi
- 申请人: Yoshinori Ikeura , Junya Shirai , Hideyuki Sugiyama , Yuji Nishikimi , Taku Kamei , Nobuki Sakauchi
- 申请人地址: JP Osaka
- 专利权人: Takeda Pharmaceutical Company Limited
- 当前专利权人: Takeda Pharmaceutical Company Limited
- 当前专利权人地址: JP Osaka
- 代理机构: Wenderoth, Lind & Ponack, L.L.P.
- 主分类号: A61K31/5355
- IPC分类号: A61K31/5355 ; A61K31/445 ; A61K31/444 ; A61K31/40 ; C07D413/04 ; C07D401/04 ; C07D211/56 ; C07D207/14
摘要:
The present invention relates to a compound represented by the formula wherein ring A is a nitrogen-containing heterocycle optionally further having substituent(s), ring B is an aromatic ring optionally having substituent(s), ring C is a cyclic group optionally having substituent(s), R1 is a hydrogen atom, a hydrocarbon group optionally having substituent(s), an acyl group, a heterocyclic group optionally having substituent(s) or an amino group optionally having substituent(s), R2 is an optionally halogenated C1-6 alkyl group, m and n are each an integer of 0 to 5, m+n is an integer of 2 to 5, and is a single bond or a double bond, or a salt thereof and the like. Since the compound has a superior tachykinin receptor antagonistic action, and is useful as an agent for the prophylaxis or treatment of various diseases such as lower urinary tract diseases, gastrointestinal diseases, central nervous system diseases and the like.