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19 条记录 (耗时 0.049 秒)

    IMINOPYRIDINE DERIVATIVES AND USES THEREOF
    3.
    发明申请
    IMINOPYRIDINE DERIVATIVES AND USES THEREOF 失效
    亚氨基吡啶衍生物及其用途

    公开(公告)号：US20110124875A1

    公开(公告)日：2011-05-26

    申请号：US13022556

    申请日：2011-02-07

    申请人： Masato YOSHIDA ,  Nobuki Sakauchi

    发明人： Masato YOSHIDA ,  Nobuki Sakauchi

    IPC分类号： C07D211/84

    CPC分类号： C07D213/82 ,  C07D401/10 ,  C07D413/10

    摘要： The present invention aims to provide an iminopyridine derivative compound having an α1D adrenergic receptor antagonistic action, which is useful as an agent for the prophylaxis or treatment of a lower urinary tract disease and the like.The present invention provides a compound represented by the formula wherein each symbol is as defined in the specification, or a salt thereof.

    摘要翻译： 本发明旨在提供具有α1D肾上腺素能受体拮抗作用的亚氨基吡啶衍生物化合物，其可用作预防或治疗下尿路疾病等。 本发明提供由下式表示的化合物，其中每个符号如说明书中所定义，或其盐。

    Nitrogen-containing heterocyclic compound and use thereof
    4.
    发明申请
    Nitrogen-containing heterocyclic compound and use thereof 有权
    含氮杂环化合物及其用途

    公开(公告)号：US20090156572A1

    公开(公告)日：2009-06-18

    申请号：US12314015

    申请日：2008-12-02

    申请人： Yoshinori Ikeura ,  Junya Shirai ,  Hideyuki Sugiyama ,  Yuji Nishikimi ,  Taku Kamei ,  Nobuki Sakauchi

    发明人： Yoshinori Ikeura ,  Junya Shirai ,  Hideyuki Sugiyama ,  Yuji Nishikimi ,  Taku Kamei ,  Nobuki Sakauchi

    IPC分类号： A61K31/397 ,  C07D413/12 ,  A61K31/5377 ,  C07D401/12 ,  A61K31/4545 ,  C07D417/14 ,  A61K31/541 ,  C07D401/14 ,  A61K31/497 ,  C07D487/04 ,  A61K31/4985

    CPC分类号： C07D211/58 ,  C07D401/12 ,  C07D401/14 ,  C07D407/12 ,  C07D409/12 ,  C07D417/14

    摘要： The present invention relates to a compound represented by the formula wherein ring A is a nitrogen-containing heterocycle optionally further having substituent(s), ring B is an aromatic ring optionally having substituent(s), ring C is a cyclic group optionally having substituent(s), R1 is a hydrogen atom, a hydrocarbon group optionally having substituent(s), an acyl group, a heterocyclic group optionally having substituent(s) or an amino group optionally having substituent(s), R2 is an optionally halogenated C1-6 alkyl group, m and n are each an integer of 0 to 5, m+n is an integer of 2 to 5, and is a single bond or a double bond, or a salt thereof and the like. Since the compound has a superior tachykinin receptor antagonistic action, and is useful as an agent for the prophylaxis or treatment of various diseases such as lower urinary tract diseases, gastrointestinal diseases, central nervous system diseases and the like.

    摘要翻译： 本发明涉及一种由下式表示的化合物：其中环A为任选具有取代基的含氮杂环，环B为任选具有取代基的芳环，环C为任选具有取代基的环状基团 R 1为氢原子，任选具有取代基的烃基，酰基，任选具有取代基的杂环基或任选具有取代基的氨基，R2为任选卤代的C1 -6烷基，m和n各自为0至5的整数，m + n为2至5的整数，并且是单键或双键，或其盐等。 由于该化合物具有优异的速激肽受体拮抗作用，并且可用作预防或治疗诸如下尿路疾病，胃肠道疾病，中枢神经系统疾病等各种疾病的药剂。

    Piperidine derivative and use thereof
    5.
    发明申请
    Piperidine derivative and use thereof 审中-公开
    哌啶衍生物及其用途

    公开(公告)号：US20070149570A1

    公开(公告)日：2007-06-28

    申请号：US11701380

    申请日：2007-02-02

    申请人： Yoshinori Ikeura ,  Junya Shirai ,  Takeshi Yoshikawa ,  Nobuki Sakauchi

    发明人： Yoshinori Ikeura ,  Junya Shirai ,  Takeshi Yoshikawa ,  Nobuki Sakauchi

    IPC分类号： C07D211/56 ,  A61K31/445

    CPC分类号： C07D211/58 ,  C07D405/12

    摘要： The present invention relates to a compound represented by the formula: wherein Ar is a phenyl group optionally having substituent(s), R1 is a hydrogen atom, a hydrocarbon group optionally having substituent(s), an acyl group or a heterocyclic group optionally having substituent(s), R2 is a hydrogen atom, a C1-6 alkyl group optionally having substituent(s) or a C3-6 cycloalkyl group optionally having substituent(s), Z is a methylene group optionally having a C1-6 alkyl group, ring A is a piperidine ring optionally further having substituent(s), ring B and ring C are benzene rings optionally further having substituent(s), and R2 optionally form a ring together with the adjacent substituent on the ring B, except the compounds represented by the formula: or a salt thereof. The compound of the present invention has a superior tachykinin receptor antagonistic action, particularly a substance P receptor antagonistic action, and is useful as a pharmaceutical agent, for example, tachykinin receptor antagonist, an agent for the prophylaxis or treatment of lower urinary tract symptoms, gastrointestinal diseases or central nerve diseases.

    摘要翻译： 本发明涉及由下式表示的化合物：其中Ar是任选具有取代基的苯基，R 1是氢原子，任选具有取代基的烃基， 酰基或任选具有取代基的杂环基，R 2是氢原子，任选具有取代基的C 1-6烷基或C 任选具有取代基的3-6个环烷基，Z是任选具有C 1-6 - 烷基的亚甲基，环A是任选进一步具有 取代基，环B和环C是任选进一步具有取代基的苯环，并且R 2任选地与环B上的相邻取代基一起形成环，除了由式 式：或其盐。 本发明的化合物具有优异的速激肽受体拮抗作用，特别是P受体拮抗作用，可用作药剂，例如速激肽受体拮抗剂，预防或治疗下尿路症状的药剂， 胃肠道疾病或中枢神经疾病。

    Nitrogen-containing heterocyclic compound and use thereof
    6.
    发明授权
    Nitrogen-containing heterocyclic compound and use thereof 有权
    含氮杂环化合物及其用途

    公开(公告)号：US08470816B2

    公开(公告)日：2013-06-25

    申请号：US12314015

    申请日：2008-12-02

    申请人： Yoshinori Ikeura ,  Junya Shirai ,  Hideyuki Sugiyama ,  Yuji Nishikimi ,  Taku Kamei ,  Nobuki Sakauchi

    发明人： Yoshinori Ikeura ,  Junya Shirai ,  Hideyuki Sugiyama ,  Yuji Nishikimi ,  Taku Kamei ,  Nobuki Sakauchi

    IPC分类号： A61K31/5355 ,  A61K31/445 ,  A61K31/444 ,  A61K31/40 ,  C07D413/04 ,  C07D401/04 ,  C07D211/56 ,  C07D207/14

    CPC分类号： C07D211/58 ,  C07D401/12 ,  C07D401/14 ,  C07D407/12 ,  C07D409/12 ,  C07D417/14

    摘要： The present invention relates to a compound represented by the formula wherein ring A is a nitrogen-containing heterocycle optionally further having substituent(s), ring B is an aromatic ring optionally having substituent(s), ring C is a cyclic group optionally having substituent(s), R1 is a hydrogen atom, a hydrocarbon group optionally having substituent(s), an acyl group, a heterocyclic group optionally having substituent(s) or an amino group optionally having substituent(s), R2 is an optionally halogenated C1-6 alkyl group, m and n are each an integer of 0 to 5, m+n is an integer of 2 to 5, and is a single bond or a double bond, or a salt thereof and the like. Since the compound has a superior tachykinin receptor antagonistic action, and is useful as an agent for the prophylaxis or treatment of various diseases such as lower urinary tract diseases, gastrointestinal diseases, central nervous system diseases and the like.

    摘要翻译： 本发明涉及一种由下式表示的化合物：其中环A为任选具有取代基的含氮杂环，环B为任选具有取代基的芳环，环C为任选具有取代基的环状基团 R 1为氢原子，任选具有取代基的烃基，酰基，任选具有取代基的杂环基或任选具有取代基的氨基，R2为任选卤代的C1 -6烷基，m和n分别为0〜5的整数，m + n为2〜5的整数，为单键或双键，或其盐等。 由于该化合物具有优异的速激肽受体拮抗作用，并且可用作预防或治疗诸如下尿路疾病，胃肠道疾病，中枢神经系统疾病等各种疾病的药剂。

    Iminopyridine derivatives and use thereof
    7.
    发明授权
    Iminopyridine derivatives and use thereof 有权
    亚氨基吡啶衍生物及其用途

    公开(公告)号：US07982044B2

    公开(公告)日：2011-07-19

    申请号：US13022563

    申请日：2011-02-07

    申请人： Masato Yoshida ,  Nobuki Sakauchi

    发明人： Masato Yoshida ,  Nobuki Sakauchi

    IPC分类号： C07D213/82

    CPC分类号： C07D213/82 ,  C07D401/10 ,  C07D413/10

    摘要： The present invention aims to provide an iminopyridine derivative compound having an α1D adrenergic receptor antagonistic action, which is useful as an agent for the prophylaxis or treatment of a lower urinary tract disease and the like. The present invention provides a compound represented by the formula wherein each symbol is as defined in the specification, or a salt thereof.

    摘要翻译： 本发明旨在提供具有α1D肾上腺素能受体拮抗作用的亚氨基吡啶衍生物化合物，其可用作预防或治疗下尿路疾病等。 本发明提供由下式表示的化合物，其中每个符号如说明书中所定义，或其盐。

    Piperidine derivative and use thereof
    8.
    发明申请
    Piperidine derivative and use thereof 审中-公开
    哌啶衍生物及其用途

    公开(公告)号：US20080275085A1

    公开(公告)日：2008-11-06

    申请号：US12081926

    申请日：2008-04-23

    申请人： Junya Shirai ,  Shinji Morimoto ,  Hideyuki Sugiyama ,  Nobuki Sakauchi ,  Takeshi Yoshikawa

    发明人： Junya Shirai ,  Shinji Morimoto ,  Hideyuki Sugiyama ,  Nobuki Sakauchi ,  Takeshi Yoshikawa

    IPC分类号： A61K31/4545 ,  C07D401/04 ,  A61P1/00 ,  A61K31/445

    CPC分类号： C07D211/60 ,  C07D401/06 ,  C07D405/06 ,  C07D409/04 ,  C07D409/14 ,  C07D413/06 ,  C07D417/06

    摘要： The present invention provides a novel piperidine derivative and a tachykinin receptor antagonist containing same, as well as a compound represented by the formula: wherein R1 is carbamoylmethyl, methylsulfonylethylcarbonyl and the like; R2 is methyl or cyclopropyl; R3 is a hydrogen atom or methyl; R4 is a chlorine atom or trifluoromethyl; R5 is a chlorine atom or trifluoromethyl; and a group represented by the formula: is a group represented by the formula: wherein R6 is a hydrogen atom, methyl, ethyl or isopropyl; R7 is a hydrogen atom, methyl or a chlorine atom; and R8 is a hydrogen atom, a fluorine atom, a chlorine atom or methyl; or 3-methylthiophen-2-yl, and a salt thereof.

    摘要翻译： 本发明提供了一种新的哌啶衍生物和含有它的速激肽受体拮抗剂，以及由下式表示的化合物：其中R 1是氨基甲酰基甲基，甲基磺酰基乙基羰基等; R 2是甲基或环丙基; R 3是氢原子或甲基; R 4是氯原子或三氟甲基; R 5是氯原子或三氟甲基; 并且由下式表示的基团是由下式表示的基团：其中R 6是氢原子，甲基，乙基或异丙基; R 7是氢原子，甲基或氯原子; R 8是氢原子，氟原子，氯原子或甲基; 或3-甲基噻吩-2-基及其盐。