A method of allowing control of a vehicle with at least two-wheels in case of puncture of a tire, each wheel including a rim and a tire associated therewith, includes the steps of: inflating each tire to an operating pressure; admitting a fluid compressed to a first pressure higher than the operating pressure of the tire into at least one tank associated with at least one of the rims; bringing the tire into communication with the tank when the inner pressure of the tire is lower than a predetermined first threshold value; detecting a variation of an inner pressure of the tank; activating a pressure measuring device when the inner pressure variation corresponds to a reduction and is higher than a first predetermined value; measuring the inner pressure of the tank with a predetermined frequency by means of (through) the pressure measuring device; calculating a variation in the inner pressure in a time unit; generating an alarm signal when the calculated inner pressure variation corresponds to a reduction and is higher than a second predetermined value; and transmitting the alarm signal to the driver.