发明授权
- 专利标题: Modified soluble FGF receptor Fc fusions method
- 专利标题(中): 改良的可溶性FGF受体Fc融合方法
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申请号: US13348297申请日: 2012-01-11
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公开(公告)号: US08481487B2公开(公告)日: 2013-07-09
- 发明人: Francis Blanche , Béatrice Cameron , Sylvie Sordello , Céline Nicolazzi , Marc Trombe , Mark Nesbit
- 申请人: Francis Blanche , Béatrice Cameron , Sylvie Sordello , Céline Nicolazzi , Marc Trombe , Mark Nesbit
- 申请人地址: FR Antony
- 专利权人: Aventis Pharma S.A.
- 当前专利权人: Aventis Pharma S.A.
- 当前专利权人地址: FR Antony
- 代理机构: Lathrop & Gage LLP
- 代理商 James H. Velema
- 优先权: EP06291824 20061128; EP07290042 20070111
- 主分类号: A61K38/18
- IPC分类号: A61K38/18
摘要:
The invention relates to modified soluble FGF receptor Fc fusions comprising a fusion of a soluble fragment or domain of the FGF receptor part (targeting or binding moiety) with an Fc region of an immunoglobulin part (effector function moiety), having improved biological activity including ADCC/CDC activities, compositions containing them, and method of producing such modified soluble FGF receptor Fc fusion molecules.
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