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1.发明授权公开(公告)号：US08399636B2
公开(公告)日：2013-03-19
申请号：US13205032
申请日：2011-08-08
CPC分类号： C12N15/1006 , C12Q1/6839
摘要： A method for double-stranded DNA purification, by which a solution containing DNA in a mixture with other components is passed over a support on which is covalently coupled an oligonucleotide capable of hybridizing with a specific sequence present on the DNA to form a triple helix.
摘要翻译： 一种用于双链DNA纯化的方法，其中将含有与其它组分的混合物中的DNA的溶液通过其上共价偶联能够与存在于DNA上的特定序列杂交的寡核苷酸以形成三螺旋的载体。
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2.发明申请公开(公告)号：US20110319605A1
公开(公告)日：2011-12-29
申请号：US13205032
申请日：2011-08-08
IPC分类号： C07H21/04
CPC分类号： C12N15/1006 , C12Q1/6839
摘要： Method for double-stranded DNA purification, by which a solution containing said DNA in a mixture with other components is passed over a support on which is covalently coupled in oligonucleotide capable of hybridizing with a specific sequence present on said DNA to form a triple helix.
摘要翻译： 用于双链DNA纯化的方法，其中将含有与其它组分的混合物中的所述DNA的溶液通过载体，其上共价偶联于寡核苷酸中，所述寡核苷酸能够与存在于所述DNA上的特定序列杂交以形成三螺旋。
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3.发明申请公开(公告)号：US20100010208A1
公开(公告)日：2010-01-14
申请号：US12478418
申请日：2009-06-04
IPC分类号： C07H21/04
CPC分类号： C12N15/1006 , C12Q1/6839
摘要： Method for double-stranded DNA purification, by which a solution containing said DNA in a mixture with other components is passed over a support on which is covalently coupled in oligonucleotide capable of hybridizing with a specific sequence present on said DNA to form a triple helix.
摘要翻译： 用于双链DNA纯化的方法，其中将含有与其它组分的混合物中的所述DNA的溶液通过载体，其上共价偶联于寡核苷酸中，所述寡核苷酸能够与存在于所述DNA上的特定序列杂交以形成三螺旋。
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公开(公告)号：US06825012B2
公开(公告)日：2004-11-30
申请号：US09981803
申请日：2001-10-19
申请人： Francis Blanche , Béatrice Cameron
发明人： Francis Blanche , Béatrice Cameron
IPC分类号： C12N121
CPC分类号： C12N15/10 , C12N15/85 , C12N2800/30 , C12N2830/002 , C12N2830/55 , C12Q1/6813 , C12Q1/6839
摘要： The invention provides double-stranded circular DNA molecules having one or more genes of interest, but lacking an origin of replication and a selectable marker, and methods for making such molecules.
摘要翻译： 本发明提供具有一个或多个感兴趣的基因但缺乏复制起点和选择性标记的双链环状DNA分子，以及制备这种分子的方法。
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公开(公告)号：US20130108641A1
公开(公告)日：2013-05-02
申请号：US13611789
申请日：2012-09-12
申请人： Nicolas Baurin , Francis Blanche , Béatrice Cameron , Tarik Dabdoubi , Jeremy Fordham , Dorothea Kominos , Jacintha Norohna , Tim Soos
发明人： Nicolas Baurin , Francis Blanche , Béatrice Cameron , Tarik Dabdoubi , Jeremy Fordham , Dorothea Kominos , Jacintha Norohna , Tim Soos
IPC分类号： C07K16/28 , A61K31/439 , A61K31/56 , A61K38/13 , A61K39/395 , A61K31/519
CPC分类号： C07K16/2866 , A61K31/439 , A61K31/519 , A61K31/56 , A61K38/13 , A61K39/3955 , A61K2039/505 , C07K16/2878 , C07K2317/24 , C07K2317/33 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92
摘要： The invention provides antibodies that specifically bind to human GITR (hGITR) with high affinity and antagonize the binding of hGITRL to hGITR. The invention also provides pharmaceutical compositions, as well as nucleic acids encoding anti-GITR antibodies, recombinant expression vectors and host cells for making such antibodies, or fragments thereof. Methods of using antibodies of the invention to detect hGITR or to modulate hGITR activity, either in vitro or in vivo, are also provided by the invention.
摘要翻译： 本发明提供以高亲和力特异性结合人GITR（hGITR）的抗体，并拮抗hGITRL与hGITR的结合。 本发明还提供药物组合物，以及编码抗GITR抗体的核酸，重组表达载体和用于制备此类抗体的宿主细胞或其片段。 本发明还提供了使用本发明的抗体来检测hGITR或调节体外或体内的hGITR活性的方法。
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6.发明授权公开(公告)号：US08017744B2
公开(公告)日：2011-09-13
申请号：US12478418
申请日：2009-06-04
IPC分类号： C07H21/02
CPC分类号： C12N15/1006 , C12Q1/6839
摘要： A method for double-stranded DNA purification, by which a solution containing DNA in a mixture with other components is passed over a support on which is covalently coupled an oligonucleotide capable of hybridizing with a specific sequence present on the DNA to form a triple helix.
摘要翻译： 一种用于双链DNA纯化的方法，其中将含有与其它组分的混合物中的DNA的溶液通过其上共价偶联能够与存在于DNA上的特定序列杂交的寡核苷酸以形成三螺旋的载体。
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公开(公告)号：US07052838B2
公开(公告)日：2006-05-30
申请号：US10104025
申请日：2002-03-25
申请人： Francis Blanche , Béatrice Cameron
发明人： Francis Blanche , Béatrice Cameron
CPC分类号： C12Q1/6839 , C12N15/1003 , C12Q2525/185
摘要： The present invention relates to novel target double-stranded DNA sequences capable of interacting with a third strand and of forming a stable triple helix. The present invention also relates to a process for purifying a double-stranded DNA molecule, according to which a solution containing said DNA molecule is brought into contact with a third DNA strand capable of forming, by hybridization, a triple helix structure with a target double-stranded DNA sequence carried by said DNA molecule.
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公开(公告)号：US06319672B1
公开(公告)日：2001-11-20
申请号：US09580923
申请日：2000-05-26
IPC分类号： C12Q168
CPC分类号： C12Q1/6839 , Y10S977/924 , C12Q2565/137
摘要： Method for double-stranded DNA purification, by which a solution containing said DNA in a mixture with other components is passed over a support on which is covalently coupled in oligonucleotide capable of hybridizing with a specific sequence present on said DNA to form a triple helix.
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9.发明授权公开(公告)号：US06649394B1
公开(公告)日：2003-11-18
申请号：US09398184
申请日：1999-09-17
IPC分类号： C12N990
摘要： A novel topoisomerase IV, nucleotide sequences coding for said enzyme, corresponding vectors, and the use of said enzyme for screening biologically active materials.
摘要翻译： 新的拓扑异构酶IV，编码所述酶的核苷酸序列，相应的载体，以及所述酶用于筛选生物活性物质的用途。
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公开(公告)号：US06410273B1
公开(公告)日：2002-06-25
申请号：US09202314
申请日：1998-12-11
申请人： Joël Crouzet , Béatrice Cameron
发明人： Joël Crouzet , Béatrice Cameron
IPC分类号： C12N1500
CPC分类号： C12N9/1007 , A61K48/00 , C12N15/1003
摘要： The invention discloses the preparation of DNA, in particular plasmid DNA. More particularly it concerns the production of bacterial plasmid DNA to be used in gene therapy, in the form of plasmid, minicircle supercoiled, loose or linear.
摘要翻译： 本发明公开了DNA的制备，特别是质粒DNA。 更具体地说，涉及用于基因治疗的细菌质粒DNA的生产，质粒的形式，小环状超螺旋的，松散的或线性的。
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