发明授权
US08487095B2 Acid addition salts, hydrates and polymorphs of 5-(2,4-dihydroxy-5-iso-propyl-phenyl)-4-(4-morpholin-4-ylmethyl-phenyl)-isoxazole-3-carboxylic acid ethylamide and formulations comprising these forms
有权
5-(2,4-二羟基-5-异丙基 - 苯基)-4-(4-吗啉-4-基甲基 - 苯基) - 异恶唑-3-甲酸乙酰胺的酸加成盐,水合物和多晶型物和包含 这些形式
- 专利标题: Acid addition salts, hydrates and polymorphs of 5-(2,4-dihydroxy-5-iso-propyl-phenyl)-4-(4-morpholin-4-ylmethyl-phenyl)-isoxazole-3-carboxylic acid ethylamide and formulations comprising these forms
- 专利标题(中): 5-(2,4-二羟基-5-异丙基 - 苯基)-4-(4-吗啉-4-基甲基 - 苯基) - 异恶唑-3-甲酸乙酰胺的酸加成盐,水合物和多晶型物和包含 这些形式
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申请号: US13415268申请日: 2012-03-08
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公开(公告)号: US08487095B2公开(公告)日: 2013-07-16
- 发明人: Martin James Drysdale , Brian William Dymock , Christoph Krell , Michael Mutz , Holger Petersen , Weijia Zheng
- 申请人: Martin James Drysdale , Brian William Dymock , Christoph Krell , Michael Mutz , Holger Petersen , Weijia Zheng
- 申请人地址: CH Basel
- 专利权人: Novartis AG,Vernalis (R&D) Ltd
- 当前专利权人: Novartis AG,Vernalis (R&D) Ltd
- 当前专利权人地址: CH Basel
- 代理商 Cozette McAvoy
- 优先权: EP07103346 20070301
- 主分类号: C07D413/10
- IPC分类号: C07D413/10
摘要:
The present invention relates to new salt forms of 5-(2,4-dihydroxy-5-isopropyl-phenyl)-4-(4-morpholin-4-ylmethyl-phenyl)-isoxazole-3-carboxylic acid ethylamide, in particular the mesylate, hydrochloride, tartrate, phosphate and hemi fumarate salt thereof; to crystalline forms of such salts; to polymorphs of 5-(2,4-dihydroxy-5-isopropyl-phenyl)-4-(4-morpholin-4-ylmethyl-phenyl)-isoxazole-3-carboxylic acid ethylamide; to hydrates and polymorphs of the new salt forms mentioned above; to the use of the new salt forms mentioned above for the manufacture of a medicament for the treatment of a disorder mediated by Hsp90; to a method for treating a disorder mediated by Hsp90 using the new salt forms; to formulations comprising such salt forms, in particular aqueous solutions suitable for intravenous administration; and to amber glass containers being filled with such formulations.
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