发明授权
US08492108B2 Methods of treating anemia and red blood cell dysfunction with lecithin cholesterol acyltransferase
有权
用卵磷脂胆固醇酰基转移酶治疗贫血和红细胞功能障碍的方法
- 专利标题： Methods of treating anemia and red blood cell dysfunction with lecithin cholesterol acyltransferase
- 专利标题（中）： 用卵磷脂胆固醇酰基转移酶治疗贫血和红细胞功能障碍的方法
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申请号： US13377586申请日： 2010-06-14
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公开(公告)号： US08492108B2公开(公告)日： 2013-07-23
- 发明人: Bruce J. Auerbach , Reynold Homan , Brian Krause
- 申请人： Bruce J. Auerbach , Reynold Homan , Brian Krause
- 国际申请： PCT/US2010/038494 WO 20100614
- 国际公布： WO2010/144904 WO 20101216
- 主分类号： C12Q1/48
- IPC分类号： C12Q1/48
摘要：
Disclosed are methods for treating conditions characterized by anemia or red blood cells dysfunction by administering an agent that increases the level of endogenous LCAT or LCAT activity. Additionally disclosed are methods of treating conditions wherein red blood cells have reduced function in relation to deformability, oxygenation, increased adhesion and aggregability, reduced nitric oxide function, or decreased life-span, increased free cholesterol, or abnormal phospholipid content. Also disclosed are methods for treating conditions characterized by an abnormal concentration of free cholesterol in red blood cells and methods of normalizing the free cholesterol content of red blood cells.
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