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    DETECTION OF LCAT ACTIVITY
    1.
    发明申请
    DETECTION OF LCAT ACTIVITY 有权
    检测LCAT活动

    公开(公告)号：US20140024061A1

    公开(公告)日：2014-01-23

    申请号：US13977161

    申请日：2011-12-28

    申请人： Bruce J. Auerbach ,  Reynold Homan ,  Brian Krause

    发明人： Bruce J. Auerbach ,  Reynold Homan ,  Brian Krause

    IPC分类号： C12Q1/48

    CPC分类号： C12Q1/48

    摘要： The present disclosure relates to methods for detecting and measuring the activity of lecithin:cholesterol acyltransferase (LCAT) in solution (e.g. serum, plasma, cell culture media, aqueous solution) with fluorescent sterol substrates. The present disclosure also relates to a method for evaluating efficacy of a therapeutic agent for stimulating LCAT and for determining endogenous LCAT activity in a patient. Also disclosed are kits that are used to carry out the aforementioned methods and methods.

    摘要翻译： 本公开涉及用荧光甾醇底物检测和测量溶液（例如血清，血浆，细胞培养基，水溶液）中卵磷脂：胆固醇酰基转移酶（LCAT）的活性的方法。 本公开还涉及用于评估用于刺激LCAT并用于确定患者中内源性LCAT活性的治疗剂的功效的方法。 还公开了用于实施上述方法和方法的试剂盒。

    Methods of treating anemia and red blood cell dysfunction with lecithin cholesterol acyltransferase
    3.
    发明授权
    Methods of treating anemia and red blood cell dysfunction with lecithin cholesterol acyltransferase 有权
    用卵磷脂胆固醇酰基转移酶治疗贫血和红细胞功能障碍的方法

    公开(公告)号：US08492108B2

    公开(公告)日：2013-07-23

    申请号：US13377586

    申请日：2010-06-14

    申请人： Bruce J. Auerbach ,  Reynold Homan ,  Brian Krause

    发明人： Bruce J. Auerbach ,  Reynold Homan ,  Brian Krause

    IPC分类号： C12Q1/48

    CPC分类号： A61K38/45 ,  A61K48/00 ,  C12N9/1029 ,  C12Y203/01043 ,  Y02A50/409 ,  Y02A50/411 ,  Y02A50/415

    摘要： Disclosed are methods for treating conditions characterized by anemia or red blood cells dysfunction by administering an agent that increases the level of endogenous LCAT or LCAT activity. Additionally disclosed are methods of treating conditions wherein red blood cells have reduced function in relation to deformability, oxygenation, increased adhesion and aggregability, reduced nitric oxide function, or decreased life-span, increased free cholesterol, or abnormal phospholipid content. Also disclosed are methods for treating conditions characterized by an abnormal concentration of free cholesterol in red blood cells and methods of normalizing the free cholesterol content of red blood cells.

    摘要翻译： 公开了通过施用增加内源性LCAT或LCAT活性水平的试剂来治疗特征在于贫血或红细胞功能障碍的病症的方法。 另外公开了治疗条件的方法，其中红细胞相对于变形性，氧合，增加的粘附性和聚集性，降低的一氧化氮功能或降低的寿命，增加的游离胆固醇或异常磷脂含量具有降低的功能。 还公开了用于治疗以红细胞中游离胆固醇异常浓度为特征的病症的方法和使血红细胞游离胆固醇含量正常化的方法。

    Detection of LCAT activity
    4.
    发明授权
    Detection of LCAT activity 有权
    检测LCAT活动

    公开(公告)号：US08728749B2

    公开(公告)日：2014-05-20

    申请号：US13977161

    申请日：2011-12-28

    申请人： Bruce J. Auerbach ,  Reynold Homan ,  Brian Krause

    发明人： Bruce J. Auerbach ,  Reynold Homan ,  Brian Krause

    IPC分类号： C12Q1/48

    CPC分类号： C12Q1/48

    摘要： The present disclosure relates to methods for detecting and measuring the activity of lecithin:cholesterol acyltransferase (LCAT) in solution (e.g. serum, plasma, cell culture media, aqueous solution) with fluorescent sterol substrates. The present disclosure also relates to a method for evaluating efficacy of a therapeutic agent for stimulating LCAT and for determining endogenous LCAT activity in a patient. Also disclosed are kits that are used to carry out the aforementioned methods and methods.

    摘要翻译： 本公开涉及用荧光甾醇底物检测和测量溶液（例如血清，血浆，细胞培养基，水溶液）中卵磷脂：胆固醇酰基转移酶（LCAT）的活性的方法。 本公开还涉及用于评估用于刺激LCAT并用于确定患者中内源性LCAT活性的治疗剂的功效的方法。 还公开了用于实施上述方法和方法的试剂盒。

    Dual inhibitors of cholesteryl ester and wax ester synthesis for sebaceous gland disorders
    8.
    发明授权
    Dual inhibitors of cholesteryl ester and wax ester synthesis for sebaceous gland disorders 失效
    双重抑制胆固醇酯和蜡酯合成皮脂腺疾病

    公开(公告)号：US06730703B2

    公开(公告)日：2004-05-04

    申请号：US10182847

    申请日：2002-08-02

    申请人： Reynold Homan

    发明人： Reynold Homan

    IPC分类号： A61K3118

    CPC分类号： A61K31/255 ,  Y10S514/864

    摘要： The present invention provides a method of treating sebaceous gland disorders comprising administering to a patient in need of said treatment an effective amount of a compound named [(2,4,6-triisopropyl-phenyl)-acetyl]-sulfamic acid 2,6-diiso-propyl-phenyl ester or a pharmaceutically acceptable salt thereof. Particularly, methods of treating sebaceous gland disorders are provided wherein said disorders are selected from seborrhea, acnes, perioral dermatitis, rosacea, and corticosteroid-induced acneiform lesions. The present invention provides methods of treating acnes such as, for example, chloracne, ciliaris acne, cystic acne, keratosa acne, vulgaris acne, senile acne, and medicinal acne.

    摘要翻译： 本发明提供了治疗皮脂腺疾病的方法，包括向需要所述治疗的患者施用有效量的命名为[（2,4,6-三异丙基 - 苯基） - 乙酰基] - 氨基磺酸2,6- 二异丙基苯基酯或其药学上可接受的盐。 特别地，提供了治疗皮脂腺疾病的方法，其中所述疾病选自皮脂溢，痤疮，口周皮炎，红斑痤疮和皮质类固醇诱发的痤疮样病变。 本发明提供治疗痤疮的方法，例如氯氰，睫毛粉刺，囊性痤疮，角化痤疮，寻常痤疮，老年痤疮和药用粉刺。