- 专利标题: Coating systems for the controlled delivery of hydrophilic bioactive agents
-
申请号: US12386469申请日: 2009-04-17
-
公开(公告)号: US08496954B2公开(公告)日: 2013-07-30
- 发明人: Ralph A. Chappa , Robert W. Hergenrother , Shannon A. Wadman , Klaus R. Wormuth
- 申请人: Ralph A. Chappa , Robert W. Hergenrother , Shannon A. Wadman , Klaus R. Wormuth
- 申请人地址: US MN Eden Prairie
- 专利权人: Surmodics, Inc.
- 当前专利权人: Surmodics, Inc.
- 当前专利权人地址: US MN Eden Prairie
- 代理机构: Kagan Binder, PLLC
- 主分类号: A61F2/00
- IPC分类号: A61F2/00 ; A61K9/50 ; A61K47/00 ; A61K38/00 ; A01N25/00
摘要:
Described are coating systems for the controlled delivery of hydrophilic bioactive agents, for example, from implantable medical devices. The coating systems of the invention comprise (a) a polymeric basecoat layer containing one or more hydrophilic bioactive agents; and (b) an elution-controlling topcoat layer that comprises a poly(ethylene-co-vinyl acetate) copolymer. The elution rate of the hydrophilic bioactive agent can be controlled by varying the vinyl acetate concentration in the elution-controlling topcoat layer.
公开/授权文献
信息查询
IPC分类: