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公开(公告)号：US08496954B2
公开(公告)日：2013-07-30
申请号：US12386469
申请日：2009-04-17
CPC分类号： A61L27/54 , A61L27/34 , A61L2300/232 , A61L2300/252 , A61L2300/256 , A61L2300/258 , A61L2300/608 , A61L2420/08 , C08L31/04
摘要： Described are coating systems for the controlled delivery of hydrophilic bioactive agents, for example, from implantable medical devices. The coating systems of the invention comprise (a) a polymeric basecoat layer containing one or more hydrophilic bioactive agents; and (b) an elution-controlling topcoat layer that comprises a poly(ethylene-co-vinyl acetate) copolymer. The elution rate of the hydrophilic bioactive agent can be controlled by varying the vinyl acetate concentration in the elution-controlling topcoat layer.
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2.发明申请公开(公告)号：US20090280155A1
公开(公告)日：2009-11-12
申请号：US12386469
申请日：2009-04-17
CPC分类号： A61L27/54 , A61L27/34 , A61L2300/232 , A61L2300/252 , A61L2300/256 , A61L2300/258 , A61L2300/608 , A61L2420/08 , C08L31/04
摘要： Described are coating systems for the controlled delivery of hydrophilic bioactive agents, for example, from implantable medical devices. The coating systems of the invention comprise (a) a polymeric basecoat layer containing one or more hydrophilic bioactive agents; and (b) an elution-controlling topcoat layer that comprises a poly(ethylene-co-vinyl acetate) copolymer. The elution rate of the hydrophilic bioactive agent can be controlled by varying the vinyl acetate concentration in the elution-controlling topcoat layer.
摘要翻译： 描述了用于例如从可植入医疗装置控制递送亲水生物活性剂的涂层系统。 本发明的涂层体系包括（a）含有一种或多种亲水性生物活性剂的聚合物底涂层; 和（b）包含聚（乙烯 - 共 - 乙酸乙烯酯）共聚物的洗脱控制面漆层。 亲水性生物活性剂的洗脱速度可以通过改变洗脱控制面漆层中的乙酸乙烯酯浓度来控制。
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