发明授权
US08501204B2 Method for producing vesicle, vesicle obtained by the production method, and W/O/W emulsion for producing vesicle
有权
生产泡囊的方法，通过生产方法获得的囊泡和用于制备囊泡的W / O / W乳液
- 专利标题： Method for producing vesicle, vesicle obtained by the production method, and W/O/W emulsion for producing vesicle
- 专利标题（中）： 生产泡囊的方法，通过生产方法获得的囊泡和用于制备囊泡的W / O / W乳液
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申请号： US12993954申请日： 2009-05-21
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公开(公告)号： US08501204B2公开(公告)日： 2013-08-06
- 发明人: Sosaku Ichikawa , Takashi Kuroiwa
- 申请人： Sosaku Ichikawa , Takashi Kuroiwa
- 申请人地址： JP Ibaraki
- 专利权人： University of Tsukuba
- 当前专利权人： University of Tsukuba
- 当前专利权人地址： JP Ibaraki
- 代理机构： Carrier Blackman & Associates, P.C.
- 代理商 William D. Blackman; Joseph P. Carrier
- 优先权： JP2008-135009 20080523
- 国际申请： PCT/JP2009/002242 WO 20090521
- 国际公布： WO2009/142018 WO 20091126
- 主分类号： A61K8/02
- IPC分类号： A61K8/02
摘要：
A vesicle is produced by: a step of producing a W/O emulsion from an aqueous solution containing a substance to be entrapped in a vesicle in a dissolved or suspended state and an organic solvent phase containing a lipid having emulsification capacity, which can constitute the vesicle; a step of producing a W/O/W emulsion from the W/O emulsion and an external water phase solution of a water-soluble emulsifier, which does not destroy a vesicle lipid membrane; and a step of removing the organic solvent phase from the W/O/W emulsion, so as to form a vesicle. This method simultaneously achieves a high entrapment yield of an active ingredient and the control of a particle diameter.
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