利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

6 条记录 (耗时 0.017 秒)

    Method for producing vesicle, vesicle obtained by the production method, and W/O/W emulsion for producing vesicle
    1.
    发明授权
    Method for producing vesicle, vesicle obtained by the production method, and W/O/W emulsion for producing vesicle 有权
    生产泡囊的方法，通过生产方法获得的囊泡和用于制备囊泡的W / O / W乳液

    公开(公告)号：US08501204B2

    公开(公告)日：2013-08-06

    申请号：US12993954

    申请日：2009-05-21

    申请人： Sosaku Ichikawa ,  Takashi Kuroiwa

    发明人： Sosaku Ichikawa ,  Takashi Kuroiwa

    IPC分类号： A61K8/02

    CPC分类号： B01J13/125 ,  A23L27/80 ,  A23P10/35 ,  A61K8/14 ,  A61K9/127 ,  A61K2800/412 ,  A61Q19/00

    摘要： A vesicle is produced by: a step of producing a W/O emulsion from an aqueous solution containing a substance to be entrapped in a vesicle in a dissolved or suspended state and an organic solvent phase containing a lipid having emulsification capacity, which can constitute the vesicle; a step of producing a W/O/W emulsion from the W/O emulsion and an external water phase solution of a water-soluble emulsifier, which does not destroy a vesicle lipid membrane; and a step of removing the organic solvent phase from the W/O/W emulsion, so as to form a vesicle. This method simultaneously achieves a high entrapment yield of an active ingredient and the control of a particle diameter.

    摘要翻译： 囊泡是通过以下步骤生产的：从含有待溶解或悬浮状态的囊泡中的物质的水溶液和含有具有乳化能力的脂质的有机溶剂相制备W / O乳液的步骤，其可以构成 囊泡 从W / O乳液和不破坏小泡脂质膜的水溶性乳化剂的外部水相溶液制备W / O / W乳液的步骤; 以及从W / O / W乳液除去有机溶剂相以形成囊泡的步骤。 该方法同时实现了活性成分的高捕获收率和粒径的控制。

    METHOD FOR PRODUCING VESICLE, VESICLE OBTAINED BY THE PRODUCTION METHOD, AND METHOD FOR PRODUCING FROZEN PARTICLE USED IN PRODUCTION OF VESICLE
    2.
    发明申请
    METHOD FOR PRODUCING VESICLE, VESICLE OBTAINED BY THE PRODUCTION METHOD, AND METHOD FOR PRODUCING FROZEN PARTICLE USED IN PRODUCTION OF VESICLE 失效
    用于生产由生产方法获得的VESICLE，VESICLE的方法和用于生产用于生产VESICLE的冷冻颗粒的方法

    公开(公告)号：US20100029791A1

    公开(公告)日：2010-02-04

    申请号：US12449882

    申请日：2008-03-03

    申请人： Sosaku Ichikawa ,  Takashi Kuroiwa

    发明人： Sosaku Ichikawa ,  Takashi Kuroiwa

    IPC分类号： B01J13/08 ,  B01F3/08

    CPC分类号： B01J13/02 ,  A61K9/1075 ,  A61K9/1272 ,  A61K9/1277 ,  Y10T428/2982 ,  Y10T428/2984 ,  Y10T428/2985 ,  Y10T428/2987 ,  Y10T428/2989

    摘要： A W/O emulsion is produced from an aqueous solution containing a substance to be entrapped in a vesicle in a dissolved or suspended state and an oil phase containing an emulsifier; subsequently, the W/O emulsion is cooled to a temperature at which the aqueous solution of the W/O emulsion becomes a frozen particle and the oil phase maintains a liquid state, and the oil phase is removed; thereafter, an oil phase containing a vesicle constituent lipid is added to the frozen particle, and the obtained mixture is then stirred, so as to substitute the emulsifier on the surface of the frozen particle with the vesicle constituent lipid; and thereafter, an external water phase is added to the frozen particle coated with a lipid membrane, so as to hydrate the lipid membrane by the external water phase. This process achieves a high entrapment yield of a desired substance while controlling desired physical properties such as particle diameter.

    摘要翻译： W / O乳液由含有被包埋在溶解或悬浮状态的囊泡中的物质的水溶液和含有乳化剂的油相产生; 随后将W / O乳液冷却至W / O乳液的水溶液变成冷冻颗粒并且油相维持液态，并除去油相的温度; 然后将含有囊泡构成脂质的油相加入到冷冻颗粒中，然后搅拌所得混合物，以用囊泡组成脂质代替冷冻颗粒表面上的乳化剂; 然后将外部水相加入到涂覆有脂质膜的冷冻颗粒中，以通过外部水相使脂质膜水合。 该方法在控制所需的物理性质如粒径的同时实现期望物质的高捕获收率。

    Method for producing vesicle, vesicle obtained by the production method, and method for producing frozen particle used in production of vesicle
    4.
    发明授权
    Method for producing vesicle, vesicle obtained by the production method, and method for producing frozen particle used in production of vesicle 失效
    生产囊泡的方法，通过生产方法获得的泡囊，以及用于生产泡囊的冷冻颗粒的生产方法

    公开(公告)号：US08246868B2

    公开(公告)日：2012-08-21

    申请号：US12449882

    申请日：2008-03-03

    申请人： Sosaku Ichikawa ,  Takashi Kuroiwa

    发明人： Sosaku Ichikawa ,  Takashi Kuroiwa

    IPC分类号： B01F3/08 ,  B01J3/08

    CPC分类号： B01J13/02 ,  A61K9/1075 ,  A61K9/1272 ,  A61K9/1277 ,  Y10T428/2982 ,  Y10T428/2984 ,  Y10T428/2985 ,  Y10T428/2987 ,  Y10T428/2989

    摘要： A W/O emulsion is produced from an aqueous solution containing a substance to be entrapped in a vesicle in a dissolved or suspended state and an oil phase containing an emulsifier; subsequently, the W/O emulsion is cooled to a temperature at which the aqueous solution of the W/O emulsion becomes a frozen particle and the oil phase maintains a liquid state, and the oil phase is removed; thereafter, an oil phase containing a vesicle constituent lipid is added to the frozen particle, and the obtained mixture is then stirred, so as to substitute the emulsifier on the surface of the frozen particle with the vesicle constituent lipid; and thereafter, an external Water phase is added to the frozen particle coated with a lipid membrane, so as to hydrate the lipid membrane by the external water phase. This process achieves a high entrapment yield of a desired substance while controlling desired physical properties such as particle diameter.

    摘要翻译： W / O乳液由含有被包埋在溶解或悬浮状态的囊泡中的物质的水溶液和含有乳化剂的油相产生; 随后将W / O乳液冷却至W / O乳液的水溶液变成冷冻颗粒并且油相维持液态，并除去油相的温度; 然后将含有囊泡构成脂质的油相加入到冷冻颗粒中，然后搅拌所得混合物，以用囊泡组成脂质代替冷冻颗粒表面上的乳化剂; 然后，将外部水相加入到涂覆有脂质膜的冷冻颗粒中，以通过外部水相使脂质膜水合。 该方法在控制所需的物理性质如粒径的同时实现期望物质的高捕获收率。

    METHOD FOR PRODUCING VESICLE, VESICLE OBTAINED BY THE PRODUCTION METHOD, AND W/O/W EMULSION FOR PRODUCING VESICLE
    5.
    发明申请
    METHOD FOR PRODUCING VESICLE, VESICLE OBTAINED BY THE PRODUCTION METHOD, AND W/O/W EMULSION FOR PRODUCING VESICLE 有权
    用于生产由生产方法获得的VESICLE，VESICLE的方法和用于生产VESICLE的W / O / W乳液

    公开(公告)号：US20110150953A1

    公开(公告)日：2011-06-23

    申请号：US12993954

    申请日：2009-05-21

    申请人： Sosaku Ichikawa ,  Takashi Kuroiwa

    发明人： Sosaku Ichikawa ,  Takashi Kuroiwa

    IPC分类号： A61K8/02 ,  A61K9/00 ,  A61K8/06 ,  A61K9/113 ,  A61K47/44 ,  A61K8/92 ,  A23L1/00 ,  A23D7/00 ,  A23D9/00 ,  A23P1/04 ,  B01J13/04

    CPC分类号： B01J13/125 ,  A23L27/80 ,  A23P10/35 ,  A61K8/14 ,  A61K9/127 ,  A61K2800/412 ,  A61Q19/00

    摘要： A vesicle is produced by: a step of producing a W/O emulsion from an aqueous solution containing a substance to be entrapped in a vesicle in a dissolved or suspended state and an organic solvent phase containing a lipid having emulsification capacity, which can constitute the vesicle; a step of producing a W/O/W emulsion from the W/O emulsion and an external water phase solution of a water-soluble emulsifier, which does not destroy a vesicle lipid membrane; and a step of removing the organic solvent phase from the W/O/W emulsion, so as to form a vesicle. This method simultaneously achieves a high entrapment yield of an active ingredient and the control of a particle diameter.

    摘要翻译： 囊泡是通过以下步骤生产的：从含有待溶解或悬浮状态的囊泡中的物质的水溶液和含有具有乳化能力的脂质的有机溶剂相制备W / O乳液的步骤，其可以构成 囊泡 从W / O乳液和不破坏小泡脂质膜的水溶性乳化剂的外部水相溶液制备W / O / W乳液的步骤; 以及从W / O / W乳液除去有机溶剂相以形成囊泡的步骤。 该方法同时实现了活性成分的高捕获收率和粒径的控制。